ID ZN135_HUMAN Reviewed; 658 AA.
AC P52742; I3L0B3; Q5U5L3; Q8N1I7;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 01-MAY-2013, entry version 109.
DE RecName: Full=Zinc finger protein 135;
DE AltName: Full=Zinc finger protein 61;
DE AltName: Full=Zinc finger protein 78-like 1;
GN Name=ZNF135; Synonyms=ZNF61, ZNF78L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT
RP ASP-22.
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
RP ASP-22.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 166-658 (ISOFORM 1).
RC TISSUE=Insulinoma;
RX PubMed=7557990; DOI=10.1006/geno.1995.1040;
RA Tommerup N., Vissing H.;
RT "Isolation and fine mapping of 16 novel human zinc finger-encoding
RT cDNAs identify putative candidate genes for developmental and
RT malignant disorders.";
RL Genomics 27:259-264(1995).
RN [6]
RP FUNCTION.
RX PubMed=21834987; DOI=10.1186/1741-7007-9-54;
RA Bai S.W., Herrera-Abreu M.T., Rohn J.L., Racine V., Tajadura V.,
RA Suryavanshi N., Bechtel S., Wiemann S., Baum B., Ridley A.J.;
RT "Identification and characterization of a set of conserved and new
RT regulators of cytoskeletal organisation, cell morphology and
RT migration.";
RL BMC Biol. 9:54-54(2011).
CC -!- FUNCTION: Plays a role in the regulation of cell morphology and
CC cytoskeletal organization. May be involved in transcriptional
CC regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P52742-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P52742-2; Sequence=VSP_046073, VSP_046074;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family.
CC -!- SIMILARITY: Contains 16 C2H2-type zinc fingers.
CC -!- SIMILARITY: Contains 1 KRAB domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC50254.1; Type=Frameshift; Positions=207, 558, 563;
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DR EMBL; AK098011; BAC05214.1; -; mRNA.
DR EMBL; AC008751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471135; EAW72553.1; -; Genomic_DNA.
DR EMBL; BC046434; AAH46434.1; -; mRNA.
DR EMBL; U09413; AAC50254.1; ALT_FRAME; mRNA.
DR IPI; IPI00395473; -.
DR IPI; IPI01013651; -.
DR PIR; I38600; I38600.
DR RefSeq; NP_001158001.1; NM_001164529.1.
DR RefSeq; NP_001158002.1; NM_001164530.1.
DR RefSeq; NP_003427.3; NM_003436.3.
DR RefSeq; NP_009065.1; NM_007134.1.
DR UniGene; Hs.85863; -.
DR ProteinModelPortal; P52742; -.
DR SMR; P52742; 7-62, 186-658.
DR STRING; 9606.ENSP00000321406; -.
DR DMDM; 296453071; -.
DR PaxDb; P52742; -.
DR PRIDE; P52742; -.
DR Ensembl; ENST00000313434; ENSP00000321406; ENSG00000176293.
DR Ensembl; ENST00000359978; ENSP00000369437; ENSG00000176293.
DR Ensembl; ENST00000439855; ENSP00000444828; ENSG00000176293.
DR GeneID; 7694; -.
DR KEGG; hsa:7694; -.
DR UCSC; uc002qre.3; human.
DR CTD; 7694; -.
DR GeneCards; GC19P058573; -.
DR HGNC; HGNC:12919; ZNF135.
DR HPA; HPA006961; -.
DR MIM; 604077; gene.
DR neXtProt; NX_P52742; -.
DR eggNOG; COG5048; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; P52742; -.
DR KO; K09228; -.
DR OrthoDB; EOG4N8R49; -.
DR PhylomeDB; P52742; -.
DR Reactome; REACT_71; Gene Expression.
DR NextBio; 29824; -.
DR ArrayExpress; P52742; -.
DR Bgee; P52742; -.
DR CleanEx; HS_ZNF135; -.
DR Genevestigator; P52742; -.
DR GermOnline; ENSG00000176293; Homo sapiens.
DR GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0007010; P:cytoskeleton organization; IMP:UniProtKB.
DR GO; GO:0022604; P:regulation of cell morphogenesis; IMP:UniProtKB.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; -; 6.
DR InterPro; IPR001909; Krueppel-associated_box.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF01352; KRAB; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 16.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 16.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW Nucleus; Polymorphism; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 658 Zinc finger protein 135.
FT /FTId=PRO_0000047419.
FT DOMAIN 14 85 KRAB.
FT ZN_FING 214 236 C2H2-type 1.
FT ZN_FING 242 264 C2H2-type 2.
FT ZN_FING 270 292 C2H2-type 3.
FT ZN_FING 298 320 C2H2-type 4.
FT ZN_FING 326 348 C2H2-type 5.
FT ZN_FING 354 376 C2H2-type 6.
FT ZN_FING 382 404 C2H2-type 7.
FT ZN_FING 410 432 C2H2-type 8.
FT ZN_FING 438 460 C2H2-type 9.
FT ZN_FING 466 488 C2H2-type 10.
FT ZN_FING 494 516 C2H2-type 11.
FT ZN_FING 522 544 C2H2-type 12.
FT ZN_FING 550 572 C2H2-type 13.
FT ZN_FING 578 600 C2H2-type 14.
FT ZN_FING 606 628 C2H2-type 15.
FT ZN_FING 634 656 C2H2-type 16.
FT VAR_SEQ 1 11 MTPGVRVSTDP -> MELGSRRRSVGCRCRGLCLAVRR
FT (in isoform 2).
FT /FTId=VSP_046073.
FT VAR_SEQ 359 638 Missing (in isoform 2).
FT /FTId=VSP_046074.
FT VARIANT 22 22 G -> D (in dbSNP:rs1469087).
FT /FTId=VAR_052774.
FT VARIANT 507 507 S -> L (in dbSNP:rs2228277).
FT /FTId=VAR_052775.
FT VARIANT 517 517 T -> A (in dbSNP:rs2228278).
FT /FTId=VAR_052776.
FT VARIANT 579 579 G -> R (in dbSNP:rs2228279).
FT /FTId=VAR_052777.
FT VARIANT 592 592 S -> L (in dbSNP:rs2228275).
FT /FTId=VAR_052778.
FT CONFLICT 166 166 G -> R (in Ref. 5; AAC50254).
SQ SEQUENCE 658 AA; 75261 MW; ED6A4FB042CB3CE5 CRC64;
MTPGVRVSTD PEQVTFEDVV VGFSQEEWGQ LKPAQRTLYR DVMLDTFRLL VSVGHWLPKP
NVISLLEQEA ELWAVESRLP QGVYPDLETR PKVKLSVLKQ GISEEISNSV ILVERFLWDG
LWYCRGEDTE GHWEWSCESL ESLAVPVAFT PVKTPVLEQW QRNGFGENIS LNPDLPHQPM
TPERQSPHTW GTRGKREKPD LNVLQKTCVK EKPYKCQECG KAFSHSSALI EHHRTHTGER
PYECHECLKG FRNSSALTKH QRIHTGEKPY KCTQCGRTFN QIAPLIQHQR THTGEKPYEC
SECGKSFSFR SSFSQHERTH TGEKPYECSE CGKAFRQSIH LTQHLRIHTG EKPYQCGECG
KAFSHSSSLT KHQRIHTGEK PYECHECGKA FTQITPLIQH QRTHTGEKPY ECGECGKAFS
QSTLLTEHRR IHTGEKPYGC NECGKTFSHS SSLSQHERTH TGEKPYECSQ CGKAFRQSTH
LTQHQRIHTG EKPYECNDCG KAFSHSSSLT KHQRIHTGEK PYECNQCGRA FSQLAPLIQH
QRIHTGEKPY ECNQCGRAFS QSSLLIEHQR IHTKEKPYGC NECGKSFSHS SSLSQHERTH
TGEKPYECHD CGKSFRQSTH LTQHRRIHTG EKPYACRDCG KAFTHSSSLT KHQRTHTG
//
