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Database: UniProt
Entry: P53641
LinkDB: P53641
Original site: P53641 
ID   SODF_PSEAE              Reviewed;         193 AA.
AC   P53641;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   16-APR-2014, entry version 95.
DE   RecName: Full=Superoxide dismutase [Fe];
DE            EC=1.15.1.1;
GN   Name=sodB; OrderedLocusNames=PA4366;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG
OS   12228).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8244935;
RA   Hassett D.J., Woodruff W.A., Wozniak D.J., Vasil M.L., Cohen M.S.,
RA   Ohman D.E.;
RT   "Cloning and characterization of the Pseudomonas aeruginosa sodA and
RT   sodB genes encoding manganese- and iron-cofactored superoxide
RT   dismutase: demonstration of increased manganese superoxide dismutase
RT   activity in alginate-producing bacteria.";
RL   J. Bacteriol. 175:7658-7665(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T.,
RA   Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an
RT   opportunistic pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Destroys superoxide anion radicals which are normally
CC       produced within the cells and which are toxic to biological
CC       systems.
CC   -!- CATALYTIC ACTIVITY: 2 superoxide + 2 H(+) = O(2) + H(2)O(2).
CC   -!- COFACTOR: Binds 1 iron ion per subunit (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase
CC       family.
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DR   EMBL; L25675; AAA16786.1; -; Unassigned_DNA.
DR   EMBL; AE004091; AAG07754.1; -; Genomic_DNA.
DR   PIR; B53294; B53294.
DR   PIR; E83100; E83100.
DR   RefSeq; NP_253056.1; NC_002516.2.
DR   ProteinModelPortal; P53641; -.
DR   SMR; P53641; 2-191.
DR   STRING; 208964.PA4366; -.
DR   GeneID; 881397; -.
DR   KEGG; pae:PA4366; -.
DR   PATRIC; 19843453; VBIPseAer58763_4573.
DR   PseudoCAP; PA4366; -.
DR   eggNOG; COG0605; -.
DR   HOGENOM; HOG000013584; -.
DR   KO; K04564; -.
DR   OMA; EHKLPPL; -.
DR   OrthoDB; EOG63NMNT; -.
DR   ProtClustDB; CLSK868614; -.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006801; P:superoxide metabolic process; IEA:InterPro.
DR   InterPro; IPR001189; Mn/Fe_SOD.
DR   InterPro; IPR019833; Mn/Fe_SOD_BS.
DR   InterPro; IPR019832; Mn/Fe_SOD_C.
DR   InterPro; IPR019831; Mn/Fe_SOD_N.
DR   PANTHER; PTHR11404; PTHR11404; 1.
DR   Pfam; PF02777; Sod_Fe_C; 1.
DR   Pfam; PF00081; Sod_Fe_N; 1.
DR   PIRSF; PIRSF000349; SODismutase; 1.
DR   PRINTS; PR01703; MNSODISMTASE.
DR   SUPFAM; SSF46609; SSF46609; 1.
DR   SUPFAM; SSF54719; SSF54719; 1.
DR   PROSITE; PS00088; SOD_MN; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Iron; Metal-binding; Oxidoreductase;
KW   Reference proteome.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    193       Superoxide dismutase [Fe].
FT                                /FTId=PRO_0000159994.
FT   METAL        27     27       Iron (By similarity).
FT   METAL        74     74       Iron (By similarity).
FT   METAL       157    157       Iron (By similarity).
FT   METAL       161    161       Iron (By similarity).
FT   CONFLICT     30     31       KH -> NN (in Ref. 1; AAA16786).
FT   CONFLICT     40     40       N -> T (in Ref. 1; AAA16786).
FT   CONFLICT     92     92       A -> G (in Ref. 1; AAA16786).
FT   CONFLICT    100    100       A -> G (in Ref. 1; AAA16786).
FT   CONFLICT    118    123       TFGSGW -> HLRFRS (in Ref. 1; AAA16786).
FT   CONFLICT    130    130       A -> P (in Ref. 1; AAA16786).
FT   CONFLICT    169    176       NLRPKYVE -> TASEVRR (in Ref. 1;
FT                                AAA16786).
SQ   SEQUENCE   193 AA;  21351 MW;  81A0FB516972188C CRC64;
     MAFELPPLPY EKNALEPHIS AETLEYHHDK HHNTYVVNLN NLIPGTEFEG KSLEEIVKSS
     SGGIFNNAAQ VWNHTFYWNC LSPNGGGQPT GALADAINAA FGSFDKFKEE FTKTSVGTFG
     SGWGWLVKKA DGSLALASTI GAGNPLTSGD TPLLTCDVWE HAYYIDYRNL RPKYVEAFWN
     LVNWDFVAKN FAA
//
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