ID SODF_PSEAE Reviewed; 193 AA.
AC P53641;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 01-MAY-2013, entry version 91.
DE RecName: Full=Superoxide dismutase [Fe];
DE EC=1.15.1.1;
GN Name=sodB; OrderedLocusNames=PA4366;
OS Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG
OS 12228).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8244935;
RA Hassett D.J., Woodruff W.A., Wozniak D.J., Vasil M.L., Cohen M.S.,
RA Ohman D.E.;
RT "Cloning and characterization of the Pseudomonas aeruginosa sodA and
RT sodB genes encoding manganese- and iron-cofactored superoxide
RT dismutase: demonstration of increased manganese superoxide dismutase
RT activity in alginate-producing bacteria.";
RL J. Bacteriol. 175:7658-7665(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T.,
RA Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an
RT opportunistic pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Destroys superoxide anion radicals which are normally
CC produced within the cells and which are toxic to biological
CC systems.
CC -!- CATALYTIC ACTIVITY: 2 superoxide + 2 H(+) = O(2) + H(2)O(2).
CC -!- COFACTOR: Binds 1 iron ion per subunit (By similarity).
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase
CC family.
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DR EMBL; L25675; AAA16786.1; -; Unassigned_DNA.
DR EMBL; AE004091; AAG07754.1; -; Genomic_DNA.
DR PIR; B53294; B53294.
DR PIR; E83100; E83100.
DR RefSeq; NP_253056.1; NC_002516.2.
DR ProteinModelPortal; P53641; -.
DR SMR; P53641; 2-191.
DR STRING; 208964.PA4366; -.
DR GeneID; 881397; -.
DR KEGG; pae:PA4366; -.
DR PATRIC; 19843453; VBIPseAer58763_4573.
DR PseudoCAP; PA4366; -.
DR eggNOG; COG0605; -.
DR HOGENOM; HOG000013584; -.
DR KO; K04564; -.
DR OMA; VEAFWNV; -.
DR ProtClustDB; CLSK868614; -.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004784; F:superoxide dismutase activity; IEA:EC.
DR GO; GO:0006801; P:superoxide metabolic process; IEA:InterPro.
DR InterPro; IPR001189; Mn/Fe_SOD.
DR InterPro; IPR019833; Mn/Fe_SOD_BS.
DR InterPro; IPR019832; Mn/Fe_SOD_C.
DR InterPro; IPR019831; Mn/Fe_SOD_N.
DR PANTHER; PTHR11404; PTHR11404; 1.
DR Pfam; PF02777; Sod_Fe_C; 1.
DR Pfam; PF00081; Sod_Fe_N; 1.
DR PIRSF; PIRSF000349; SODismutase; 1.
DR PRINTS; PR01703; MNSODISMTASE.
DR SUPFAM; SSF46609; SODismutase; 1.
DR SUPFAM; SSF54719; SODismutase; 1.
DR PROSITE; PS00088; SOD_MN; 1.
PE 3: Inferred from homology;
KW Complete proteome; Iron; Metal-binding; Oxidoreductase;
KW Reference proteome.
FT INIT_MET 1 1 Removed (By similarity).
FT CHAIN 2 193 Superoxide dismutase [Fe].
FT /FTId=PRO_0000159994.
FT METAL 27 27 Iron (By similarity).
FT METAL 74 74 Iron (By similarity).
FT METAL 157 157 Iron (By similarity).
FT METAL 161 161 Iron (By similarity).
FT CONFLICT 30 31 KH -> NN (in Ref. 1; AAA16786).
FT CONFLICT 40 40 N -> T (in Ref. 1; AAA16786).
FT CONFLICT 92 92 A -> G (in Ref. 1; AAA16786).
FT CONFLICT 100 100 A -> G (in Ref. 1; AAA16786).
FT CONFLICT 118 123 TFGSGW -> HLRFRS (in Ref. 1; AAA16786).
FT CONFLICT 130 130 A -> P (in Ref. 1; AAA16786).
FT CONFLICT 169 176 NLRPKYVE -> TASEVRR (in Ref. 1;
FT AAA16786).
SQ SEQUENCE 193 AA; 21351 MW; 81A0FB516972188C CRC64;
MAFELPPLPY EKNALEPHIS AETLEYHHDK HHNTYVVNLN NLIPGTEFEG KSLEEIVKSS
SGGIFNNAAQ VWNHTFYWNC LSPNGGGQPT GALADAINAA FGSFDKFKEE FTKTSVGTFG
SGWGWLVKKA DGSLALASTI GAGNPLTSGD TPLLTCDVWE HAYYIDYRNL RPKYVEAFWN
LVNWDFVAKN FAA
//
