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Database: UniProt
Entry: P54624
LinkDB: P54624
Original site: P54624 
ID   TRYA_DROER              Reviewed;         256 AA.
AC   P54624;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   13-NOV-2013, entry version 70.
DE   RecName: Full=Trypsin alpha;
DE            EC=3.4.21.4;
DE   Flags: Precursor;
GN   Name=alphaTry;
OS   Drosophila erecta (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7220;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10486967;
RA   Wang S., Magoulas C., Hickey D.A.;
RT   "Concerted evolution within a trypsin gene cluster in Drosophila.";
RL   Mol. Biol. Evol. 16:1117-1124(1999).
CC   -!- CATALYTIC ACTIVITY: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC   -!- SIMILARITY: Contains 1 peptidase S1 domain.
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DR   EMBL; U40653; AAA83239.1; -; Genomic_DNA.
DR   ProteinModelPortal; P54624; -.
DR   MEROPS; S01.110; -.
DR   FlyBase; FBgn0015076; Dere\alphaTry.
DR   OrthoDB; EOG7MKW6Q; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR001254; Peptidase_S1.
DR   InterPro; IPR018114; Peptidase_S1_AS.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR009003; Trypsin-like_Pept_dom.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Hydrolase; Protease; Secreted; Serine protease;
KW   Signal; Zymogen.
FT   SIGNAL        1     22       Probable.
FT   PROPEP       23     30       Activation peptide.
FT                                /FTId=PRO_0000028259.
FT   CHAIN        31    256       Trypsin alpha.
FT                                /FTId=PRO_0000028260.
FT   DOMAIN       31    254       Peptidase S1.
FT   ACT_SITE     71     71       Charge relay system (By similarity).
FT   ACT_SITE    116    116       Charge relay system (By similarity).
FT   ACT_SITE    210    210       Charge relay system (By similarity).
FT   SITE        204    204       Required for specificity (By similarity).
FT   DISULFID     56     72       By similarity.
FT   DISULFID    180    197       By similarity.
FT   DISULFID    206    230       By similarity.
SQ   SEQUENCE   256 AA;  25991 MW;  32C4B5BED84BCC2D CRC64;
     MLKIVILLSA VVCALGGTVP EGLLPQLDGR IVGGSATTIS SFPWQISLQR SGSHSCGGSV
     YSANIIVTAA HCLQSVSASS LQVRAGSTYW SSGGVVAKVA AFRNHEGYNA NTMVNDIAVI
     RLSSSLSFSS SIKAIALATY NPANGAAAAV SGWGTQSSGS NSIPSQLQYV NVNIVSQSKC
     ASSAYGYGSE IRNTMICAAA SGKDACQGDS GGPLVSGGVL VGVVSWGYGC AYSNYPGVYA
     DVAVLRSWVI STANSI
//
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