ID IL10_FELCA Reviewed; 178 AA.
AC P55029; Q9TSJ7;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 2.
DT 01-MAY-2013, entry version 79.
DE RecName: Full=Interleukin-10;
DE Short=IL-10;
DE AltName: Full=Cytokine synthesis inhibitory factor;
DE Short=CSIF;
DE Flags: Precursor;
GN Name=IL10;
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC Felinae; Felis.
OX NCBI_TaxID=9685;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Scott B.M., O'Reilly K.L.;
RL Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Leutenegger C.M., Huder J.B., Mislin C., Hofmann-Lehmann R., Fehr D.,
RA Dean G.A., Higgins J., Pedersen N.C., Lutz H.;
RT "Molecular cloning and expression of feline interleukin-10.";
RL Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibits the synthesis of a number of cytokines,
CC including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by
CC activated macrophages and by helper T-cells (By similarity).
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the IL-10 family.
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DR EMBL; U39569; AAA81771.1; -; mRNA.
DR EMBL; AF060520; AAC64708.1; -; mRNA.
DR RefSeq; NP_001009209.1; NM_001009209.1.
DR ProteinModelPortal; P55029; -.
DR SMR; P55029; 24-177.
DR Ensembl; ENSFCAT00000013519; ENSFCAP00000012535; ENSFCAG00000013515.
DR GeneID; 493683; -.
DR KEGG; fca:493683; -.
DR CTD; 3586; -.
DR eggNOG; NOG43085; -.
DR GeneTree; ENSGT00510000048535; -.
DR HOGENOM; HOG000072692; -.
DR HOVERGEN; HBG004110; -.
DR KO; K05443; -.
DR OrthoDB; EOG4F1X4G; -.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0060670; P:branching involved in labyrinthine layer morphogenesis; IEA:Compara.
DR GO; GO:0042742; P:defense response to bacterium; IEA:Compara.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; ISS:UniProtKB.
DR GO; GO:0030889; P:negative regulation of B cell proliferation; ISS:UniProtKB.
DR GO; GO:0002875; P:negative regulation of chronic inflammatory response to antigenic stimulus; IEA:Compara.
DR GO; GO:0002740; P:negative regulation of cytokine secretion involved in immune response; ISS:UniProtKB.
DR GO; GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Compara.
DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IEA:Compara.
DR GO; GO:0032695; P:negative regulation of interleukin-12 production; IEA:Compara.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; ISS:UniProtKB.
DR GO; GO:0051045; P:negative regulation of membrane protein ectodomain proteolysis; ISS:UniProtKB.
DR GO; GO:0030886; P:negative regulation of myeloid dendritic cell activation; IEA:Compara.
DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Compara.
DR GO; GO:0002904; P:positive regulation of B cell apoptotic process; ISS:UniProtKB.
DR GO; GO:0050715; P:positive regulation of cytokine secretion; ISS:UniProtKB.
DR GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IEA:Compara.
DR GO; GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
DR GO; GO:0032800; P:receptor biosynthetic process; ISS:UniProtKB.
DR GO; GO:0051384; P:response to glucocorticoid stimulus; ISS:UniProtKB.
DR GO; GO:0002237; P:response to molecule of bacterial origin; ISS:UniProtKB.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR012351; 4_helix_cytokine_core.
DR InterPro; IPR020443; Interleukin-10/19/20/24.
DR InterPro; IPR020423; Interleukin-10_CS.
DR InterPro; IPR000098; Interleukin_10.
DR PANTHER; PTHR11585; PTHR11585; 1.
DR Pfam; PF00726; IL10; 1.
DR PRINTS; PR01294; INTRLEUKIN10.
DR SMART; SM00188; IL10; 1.
DR SUPFAM; SSF47266; 4_helix_cytokine; 1.
DR PROSITE; PS00520; INTERLEUKIN_10; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Cytokine; Disulfide bond; Glycoprotein; Secreted;
KW Signal.
FT SIGNAL 1 18 Potential.
FT CHAIN 19 178 Interleukin-10.
FT /FTId=PRO_0000015358.
FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 134 134 N-linked (GlcNAc...) (Potential).
FT DISULFID 30 126 By similarity.
FT DISULFID 80 132 By similarity.
SQ SEQUENCE 178 AA; 20575 MW; 86A3FE97D9C18D08 CRC64;
MHSSALLCFL VFLAGVGASR HQSTLSEDNC THFSVSLPHM LRELRAAFGK VKTFFQTKDE
LHSILLTRSL LEDFKGYLGC QALSEMIQFY LEEVMPQAEN EDPDIKQHVN SLGEKLKTLR
LRLRRCHRFL PCENKSKVVE QVKSTFSKLQ EKGVYKAMGE FDIFINYIEA YMTMKMKI
//
