GenomeNet

Database: UniProt
Entry: P55029
LinkDB: P55029
Original site: P55029 
ID   IL10_FELCA              Reviewed;         178 AA.
AC   P55029; Q9TSJ7;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2004, sequence version 2.
DT   29-OCT-2014, entry version 87.
DE   RecName: Full=Interleukin-10;
DE            Short=IL-10;
DE   AltName: Full=Cytokine synthesis inhibitory factor;
DE            Short=CSIF;
DE   Flags: Precursor;
GN   Name=IL10;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Scott B.M., O'Reilly K.L.;
RL   Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Leutenegger C.M., Huder J.B., Mislin C., Hofmann-Lehmann R., Fehr D.,
RA   Dean G.A., Higgins J., Pedersen N.C., Lutz H.;
RT   "Molecular cloning and expression of feline interleukin-10.";
RL   Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits the synthesis of a number of cytokines,
CC       including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by
CC       activated macrophages and by helper T-cells. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-10 family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; U39569; AAA81771.1; -; mRNA.
DR   EMBL; AF060520; AAC64708.1; -; mRNA.
DR   RefSeq; NP_001009209.1; NM_001009209.1.
DR   ProteinModelPortal; P55029; -.
DR   SMR; P55029; 24-177.
DR   GeneID; 493683; -.
DR   KEGG; fca:493683; -.
DR   CTD; 3586; -.
DR   eggNOG; NOG43085; -.
DR   HOGENOM; HOG000072692; -.
DR   HOVERGEN; HBG004110; -.
DR   InParanoid; P55029; -.
DR   KO; K05443; -.
DR   TreeFam; TF333253; -.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; ISS:UniProtKB.
DR   GO; GO:0030889; P:negative regulation of B cell proliferation; ISS:UniProtKB.
DR   GO; GO:0002740; P:negative regulation of cytokine secretion involved in immune response; ISS:UniProtKB.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; ISS:UniProtKB.
DR   GO; GO:0051045; P:negative regulation of membrane protein ectodomain proteolysis; ISS:UniProtKB.
DR   GO; GO:0002904; P:positive regulation of B cell apoptotic process; ISS:UniProtKB.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; ISS:UniProtKB.
DR   GO; GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0032800; P:receptor biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0051384; P:response to glucocorticoid; ISS:UniProtKB.
DR   GO; GO:0002237; P:response to molecule of bacterial origin; ISS:UniProtKB.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR012351; 4_helix_cytokine_core.
DR   InterPro; IPR000098; IL-10.
DR   InterPro; IPR020443; IL-10/19/20/24/26_fam.
DR   InterPro; IPR020423; IL-10_CS.
DR   PANTHER; PTHR11585; PTHR11585; 1.
DR   Pfam; PF00726; IL10; 1.
DR   PRINTS; PR01294; INTRLEUKIN10.
DR   SMART; SM00188; IL10; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00520; INTERLEUKIN_10; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL        1     18       {ECO:0000255}.
FT   CHAIN        19    178       Interleukin-10.
FT                                /FTId=PRO_0000015358.
FT   CARBOHYD     29     29       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    134    134       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID     30    126       {ECO:0000250}.
FT   DISULFID     80    132       {ECO:0000250}.
SQ   SEQUENCE   178 AA;  20575 MW;  86A3FE97D9C18D08 CRC64;
     MHSSALLCFL VFLAGVGASR HQSTLSEDNC THFSVSLPHM LRELRAAFGK VKTFFQTKDE
     LHSILLTRSL LEDFKGYLGC QALSEMIQFY LEEVMPQAEN EDPDIKQHVN SLGEKLKTLR
     LRLRRCHRFL PCENKSKVVE QVKSTFSKLQ EKGVYKAMGE FDIFINYIEA YMTMKMKI
//
DBGET integrated database retrieval system