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Database: UniProt
Entry: P56110
LinkDB: P56110
Original site: P56110 
ID   G6PD_HELPY              Reviewed;         425 AA.
AC   P56110;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-SEP-2014, entry version 93.
DE   RecName: Full=Glucose-6-phosphate 1-dehydrogenase;
DE            Short=G6PD;
DE            EC=1.1.1.49;
GN   Name=zwf; OrderedLocusNames=HP_1101;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter
OS   pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R.,
RA   Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F.,
RA   Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G.,
RA   Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D.,
RA   Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D.,
RA   Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C.,
RA   Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D.,
RA   Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- FUNCTION: Catalyzes the oxidation of glucose 6-phosphate to 6-
CC       phosphogluconolactone (By similarity).
CC   -!- CATALYTIC ACTIVITY: D-glucose 6-phosphate + NADP(+) = 6-phospho-D-
CC       glucono-1,5-lactone + NADPH.
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage):
CC       step 1/3.
CC   -!- SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase
CC       family.
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DR   EMBL; AE000511; AAD08144.1; -; Genomic_DNA.
DR   PIR; E64657; E64657.
DR   RefSeq; NP_207892.1; NC_000915.1.
DR   RefSeq; YP_006935016.1; NC_018939.1.
DR   ProteinModelPortal; P56110; -.
DR   STRING; 85962.HP1101; -.
DR   PRIDE; P56110; -.
DR   EnsemblBacteria; AAD08144; AAD08144; HP_1101.
DR   GeneID; 13870294; -.
DR   GeneID; 899637; -.
DR   KEGG; heo:C694_05680; -.
DR   KEGG; hpy:HP1101; -.
DR   PATRIC; 20593541; VBIHelPyl33062_1150.
DR   eggNOG; COG0364; -.
DR   KO; K00036; -.
DR   OMA; WNAAHID; -.
DR   OrthoDB; EOG61308Z; -.
DR   BioCyc; HPY:HP1101-MONOMER; -.
DR   UniPathway; UPA00115; UER00408.
DR   GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0050661; F:NADP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.40.50.720; -; 1.
DR   HAMAP; MF_00966; G6PD; 1.
DR   InterPro; IPR001282; G6P_DH.
DR   InterPro; IPR019796; G6P_DH_AS.
DR   InterPro; IPR022675; G6P_DH_C.
DR   InterPro; IPR022674; G6P_DH_NAD-bd.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   PANTHER; PTHR23429; PTHR23429; 1.
DR   Pfam; PF02781; G6PD_C; 2.
DR   Pfam; PF00479; G6PD_N; 1.
DR   PIRSF; PIRSF000110; G6PD; 1.
DR   PRINTS; PR00079; G6PDHDRGNASE.
DR   PROSITE; PS00069; G6P_DEHYDROGENASE; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Glucose metabolism; NADP;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN         1    425       Glucose-6-phosphate 1-dehydrogenase.
FT                                /FTId=PRO_0000068123.
FT   ACT_SITE    225    225       Proton acceptor (By similarity).
FT   BINDING      44     44       NADP (By similarity).
FT   BINDING     135    135       NADP (By similarity).
FT   BINDING     165    165       Substrate (By similarity).
FT   BINDING     169    169       Substrate (By similarity).
FT   BINDING     201    201       Substrate (By similarity).
FT   BINDING     220    220       Substrate (By similarity).
FT   BINDING     311    311       Substrate (By similarity).
SQ   SEQUENCE   425 AA;  49541 MW;  EF5A5C1C5AC7B6DB CRC64;
     MLDFDLVLFG ATGDLAMRKL FVSLYEIYTH YGFKNDSRII ASGRKELSNE EFLTLLCEKT
     QLHSREKGRE FLAHISYLCV RLDNPKDFEE LSKIATKNKP LIFYFSISPS FFATTAQHLA
     KNALNHANTR LILEKPLGHD LKTCKEIFQS ISVFFKEEQI FRIDHYLGKK GVQNILELRL
     NNPILNILWD QISAVEICVY ETLGVEERGE FYDKIGALRD MVQNHLLQVL SLIATDLPNN
     LKDLRKEKIK VLKTLQPPKD FKKQVIRAQY QGYRDENKVH KESQTETFVA IKAFLDTPKF
     KGVPFYLKHA KKMPHNQASV KIHFNAVNTL EFFLSQDKIT LTLKDHQNPL ILETHNKQEF
     LRPYAKLLYD AIQNNHNNFA HQLELEASWV FIDTLIEGFM NNATPLYSYE SHHLNESEFL
     KPLYQ
//
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