ID GBRR2_MOUSE Reviewed; 465 AA.
AC P56476; Q6PEP0;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2012, sequence version 4.
DT 29-MAY-2013, entry version 108.
DE RecName: Full=Gamma-aminobutyric acid receptor subunit rho-2;
DE AltName: Full=GABA(A) receptor subunit rho-2;
DE AltName: Full=GABA(C) receptor;
DE Flags: Precursor;
GN Name=Gabrr2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Retina;
RA Greka A., Koolen J.A., Lipton S.A., Zhang D.;
RT "Molecular cloning of GABA rho subunits in the mouse retina.";
RL Abstr. - Soc. Neurosci. 23:1262-1262(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: GABA, the major inhibitory neurotransmitter in the
CC vertebrate brain, mediates neuronal inhibition by binding to the
CC GABA/benzodiazepine receptor and opening an integral chloride
CC channel. Rho-2 GABA receptor could play a role in retinal
CC neurotransmission (By similarity).
CC -!- SUBUNIT: Generally pentameric. There are five types of GABA(A)
CC receptor chains: alpha, beta, gamma, delta, and rho. Interacts
CC with SQSTM1 (By similarity).
CC -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
CC membrane; Multi-pass membrane protein (By similarity). Cell
CC membrane; Multi-pass membrane protein (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative initiation; Named isoforms=2;
CC Name=1;
CC IsoId=P56476-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P56476-2; Sequence=VSP_044374;
CC Note=Isoform 2 could be translated from an upstream initiator
CC ATG located in frame within the first coding exon. The
CC probability of a signal peptide within this isoform is very low.
CC No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
CC GABRR2 sub-subfamily.
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DR EMBL; AF024621; AAB81965.1; -; mRNA.
DR EMBL; CH466538; EDL05492.1; -; Genomic_DNA.
DR EMBL; BC057957; AAH57957.2; -; mRNA.
DR IPI; IPI00113786; -.
DR RefSeq; NP_032102.2; NM_008076.3.
DR UniGene; Mm.6227; -.
DR ProteinModelPortal; P56476; -.
DR SMR; P56476; 64-349.
DR PhosphoSite; P56476; -.
DR PRIDE; P56476; -.
DR Ensembl; ENSMUST00000024035; ENSMUSP00000024035; ENSMUSG00000023267.
DR Ensembl; ENSMUST00000108162; ENSMUSP00000103797; ENSMUSG00000023267.
DR GeneID; 14409; -.
DR KEGG; mmu:14409; -.
DR UCSC; uc008sfq.1; mouse.
DR CTD; 2570; -.
DR MGI; MGI:95626; Gabrr2.
DR eggNOG; NOG77438; -.
DR GeneTree; ENSGT00630000089571; -.
DR HOGENOM; HOG000231335; -.
DR HOVERGEN; HBG051707; -.
DR InParanoid; Q6PEP0; -.
DR KO; K05190; -.
DR OMA; GFRIFQN; -.
DR OrthoDB; EOG4RJG1G; -.
DR ChEMBL; CHEMBL2220; -.
DR NextBio; 285985; -.
DR ArrayExpress; P56476; -.
DR Bgee; P56476; -.
DR Genevestigator; P56476; -.
DR GermOnline; ENSMUSG00000023267; Mus musculus.
DR GO; GO:0030424; C:axon; TAS:MGI.
DR GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR GO; GO:0004890; F:GABA-A receptor activity; IMP:MGI.
DR GO; GO:0006821; P:chloride transport; TAS:MGI.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IMP:MGI.
DR GO; GO:0007601; P:visual perception; IMP:MGI.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006028; GABAA_rcpt.
DR InterPro; IPR008059; GABAAa_rho2_rcpt.
DR InterPro; IPR008057; GABAAa_rho_rcpt.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00253; GABAARECEPTR.
DR PRINTS; PR01670; GABAARRHO.
DR PRINTS; PR01672; GABAARRHO2.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neu_channel_TM; 1.
DR SUPFAM; SSF63712; Neur_chan_LBD; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Alternative initiation; Cell junction; Cell membrane; Chloride;
KW Chloride channel; Complete proteome; Disulfide bond; Glycoprotein;
KW Ion channel; Ion transport; Membrane; Postsynaptic cell membrane;
KW Reference proteome; Signal; Synapse; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1 20 Potential.
FT CHAIN 21 465 Gamma-aminobutyric acid receptor subunit
FT rho-2.
FT /FTId=PRO_0000000489.
FT TOPO_DOM 21 260 Extracellular (Probable).
FT TRANSMEM 261 281 Helical; (Potential).
FT TRANSMEM 294 314 Helical; (Potential).
FT TRANSMEM 326 346 Helical; (Potential).
FT TOPO_DOM 347 443 Cytoplasmic (Probable).
FT TRANSMEM 444 464 Helical; (Potential).
FT CARBOHYD 120 120 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 254 254 N-linked (GlcNAc...) (Potential).
FT DISULFID 178 192 By similarity.
FT VAR_SEQ 1 1 M -> MVKPGGILPIKSPCTAACCIIDMCRM (in
FT isoform 2).
FT /FTId=VSP_044374.
FT CONFLICT 33 33 E -> D (in Ref. 1; AAB81965).
FT CONFLICT 52 52 P -> A (in Ref. 1; AAB81965).
FT CONFLICT 59 59 L -> F (in Ref. 1; AAB81965).
FT CONFLICT 88 88 L -> V (in Ref. 1; AAB81965).
FT CONFLICT 105 105 R -> K (in Ref. 1; AAB81965).
FT CONFLICT 109 109 R -> K (in Ref. 1; AAB81965).
FT CONFLICT 149 149 H -> Q (in Ref. 1; AAB81965).
FT CONFLICT 357 357 R -> L (in Ref. 1; AAB81965).
FT CONFLICT 366 366 M -> V (in Ref. 1; AAB81965).
FT CONFLICT 372 372 S -> A (in Ref. 1; AAB81965).
FT CONFLICT 394 394 R -> T (in Ref. 1; AAB81965).
FT CONFLICT 400 400 E -> K (in Ref. 1; AAB81965).
FT CONFLICT 421 421 R -> K (in Ref. 1; AAB81965).
FT CONFLICT 429 429 Q -> R (in Ref. 1; AAB81965).
SQ SEQUENCE 465 AA; 54231 MW; B44B51B572468A20 CRC64;
MPYLMRLALV LFCLMALVES RKPRRKRWTG LLETSKPSHL YKKNLDVTKM RPGKPRPLLR
VEDHDFTMRP AFGGPAIPVG VDVQVESLDS ISEVDMDFTM TLYLRHYWRD ERLAFPSSSN
KSMTFDGRLV KKIWVPDVFF VHSKRSFIHD TTTDNIMLRV FPDGHVLYSM RITVTAMCNM
DFSHFPLDSQ TCSLELESYA YTDEDLMLYW KNGDESLKTD EKISLSQFLI QKFHTTSRLA
FYSSTGWYNR LYINFTLRRH IFFFLLQTYF PATLMVMLSW VSFWIDHRAV PARVSLGIMT
VLTMSTIITG VNASMPRVSY IRAVDIYLWV SFVFVFLSVL EYAAVNYLTT LQEQKERKFR
EKLPCMCGML HSRTMMLDGS YSESEANSLA GYPRSHILPE EERPDNIVVH LALNSELTSS
RKKGLLKGQM GLYIFQNTHA IDKYSRLIFP AFYIVFNLIY WSVFS
//
