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Database: UniProt
Entry: P58663
LinkDB: P58663
Original site: P58663 
ID   RCSB_SALTY              Reviewed;         216 AA.
AC   P58663;
DT   31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   31-JAN-2002, sequence version 1.
DT   16-APR-2014, entry version 85.
DE   RecName: Full=Transcriptional regulatory protein RcsB;
GN   Name=rcsB; OrderedLocusNames=STM2270;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M.,
RA   Waterston R., Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium
RT   LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Component of the Rcs signaling system, which controls
CC       transcription of numerous genes. RcsB is the response regulator
CC       that binds to regulatory DNA regions. Can function both in an
CC       RcsA-dependent or RcsA-independent manner (By similarity).
CC   -!- SUBUNIT: Interacts with RcsD and RcsA (By similarity).
CC   -!- PTM: Phosphorylated and activated by RcsD (By similarity).
CC   -!- SIMILARITY: Belongs to the RcsB family.
CC   -!- SIMILARITY: Contains 1 HTH luxR-type DNA-binding domain.
CC   -!- SIMILARITY: Contains 1 response regulatory domain.
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DR   EMBL; AE006468; AAL21171.1; -; Genomic_DNA.
DR   RefSeq; NP_461212.1; NC_003197.1.
DR   ProteinModelPortal; P58663; -.
DR   SMR; P58663; 129-215.
DR   STRING; 99287.STM2270; -.
DR   PaxDb; P58663; -.
DR   PRIDE; P58663; -.
DR   EnsemblBacteria; AAL21171; AAL21171; STM2270.
DR   GeneID; 1253792; -.
DR   KEGG; stm:STM2270; -.
DR   PATRIC; 32383147; VBISalEnt20916_2403.
DR   eggNOG; COG2197; -.
DR   HOGENOM; HOG000034813; -.
DR   KO; K07687; -.
DR   OMA; TISTQKK; -.
DR   OrthoDB; EOG69GZGV; -.
DR   ProtClustDB; PRK10840; -.
DR   BioCyc; SENT99287:GCTI-2285-MONOMER; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00981; RcsB; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Complete proteome; DNA-binding; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN         1    216       Transcriptional regulatory protein RcsB.
FT                                /FTId=PRO_0000081213.
FT   DOMAIN        5    124       Response regulatory.
FT   DOMAIN      144    209       HTH luxR-type.
FT   DNA_BIND    168    187       H-T-H motif (By similarity).
FT   MOD_RES      56     56       4-aspartylphosphate (By similarity).
SQ   SEQUENCE   216 AA;  23715 MW;  A63D1BCF704E0680 CRC64;
     MNNMNVIIAD DHPIVLFGIR KSLEQIEWVN VVGEFEDSTA LINNLPKLDA HVLITDLSMP
     GDKYGDGITL IKYIKRHFPS LSIIVLTMNN NPAILSAVLD LDIEGIVLKQ GAPTDLPKAL
     AALQKGKKFT PESVSRLLEK ISAGGYGDKR LSPKESEVLR LFAEGFLVTE IAKKLNRSIK
     TISSQKKSAM MKLGVENDIA LLNYLSSVTL SPTDKE
//
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