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Database: UniProt
Entry: P59915
LinkDB: P59915
Original site: P59915 
ID   HAGA1_PORGI             Reviewed;        2164 AA.
AC   P59915;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   10-OCT-2003, sequence version 1.
DT   07-JUN-2017, entry version 81.
DE   RecName: Full=Hemagglutinin A;
DE   Flags: Precursor;
GN   Name=hagA; OrderedLocusNames=PG_1837;
OS   Porphyromonas gingivalis (strain ATCC BAA-308 / W83).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales;
OC   Porphyromonadaceae; Porphyromonas.
OX   NCBI_TaxID=242619;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-308 / W83;
RX   PubMed=12949112; DOI=10.1128/JB.185.18.5591-5601.2003;
RA   Nelson K.E., Fleischmann R.D., DeBoy R.T., Paulsen I.T., Fouts D.E.,
RA   Eisen J.A., Daugherty S.C., Dodson R.J., Durkin A.S., Gwinn M.L.,
RA   Haft D.H., Kolonay J.F., Nelson W.C., Mason T.M., Tallon L., Gray J.,
RA   Granger D., Tettelin H., Dong H., Galvin J.L., Duncan M.J.,
RA   Dewhirst F.E., Fraser C.M.;
RT   "Complete genome sequence of the oral pathogenic bacterium
RT   Porphyromonas gingivalis strain W83.";
RL   J. Bacteriol. 185:5591-5601(2003).
CC   -!- FUNCTION: Agglutinates erythrocytes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C25 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAQ66831.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; AE015924; AAQ66831.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_043876452.1; NC_002950.2.
DR   PDB; 3KM5; X-ray; 1.40 A; A/B=1137-1314.
DR   PDBsum; 3KM5; -.
DR   SMR; P59915; -.
DR   STRING; 242619.PG1837; -.
DR   EnsemblBacteria; AAQ66831; AAQ66831; PG_1837.
DR   KEGG; pgi:PG_1837; -.
DR   PATRIC; fig|242619.8.peg.1698; -.
DR   eggNOG; ENOG41061HS; Bacteria.
DR   eggNOG; ENOG4112AJT; LUCA.
DR   OMA; AFRHFGC; -.
DR   EvolutionaryTrace; P59915; -.
DR   Proteomes; UP000000588; Chromosome.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.260; -; 8.
DR   Gene3D; 2.60.40.10; -; 5.
DR   InterPro; IPR011628; Cleaved_adhesin.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR008979; Galactose-bd-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR018832; Pept_C25_gingipain_C.
DR   Pfam; PF07675; Cleaved_Adhesin; 8.
DR   Pfam; PF10365; DUF2436; 1.
DR   SMART; SM00060; FN3; 5.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Hemagglutinin; Hydrolase; Protease;
KW   Reference proteome; Repeat; Signal; Thiol protease; Virulence.
FT   SIGNAL        1     25       {ECO:0000255}.
FT   CHAIN        26   2164       Hemagglutinin A.
FT                                /FTId=PRO_0000026537.
FT   REGION       26    539       Peptidase C25-like 1.
FT   REGION      540    991       Peptidase C25-like 2.
FT   REGION      992   1443       Peptidase C25-like 3.
FT   STRAND     1139   1141       {ECO:0000244|PDB:3KM5}.
FT   STRAND     1156   1159       {ECO:0000244|PDB:3KM5}.
FT   STRAND     1168   1171       {ECO:0000244|PDB:3KM5}.
FT   TURN       1172   1174       {ECO:0000244|PDB:3KM5}.
FT   STRAND     1181   1196       {ECO:0000244|PDB:3KM5}.
FT   STRAND     1200   1204       {ECO:0000244|PDB:3KM5}.
FT   STRAND     1213   1220       {ECO:0000244|PDB:3KM5}.
FT   STRAND     1229   1236       {ECO:0000244|PDB:3KM5}.
FT   HELIX      1240   1242       {ECO:0000244|PDB:3KM5}.
FT   STRAND     1243   1249       {ECO:0000244|PDB:3KM5}.
FT   STRAND     1263   1265       {ECO:0000244|PDB:3KM5}.
FT   STRAND     1277   1282       {ECO:0000244|PDB:3KM5}.
FT   STRAND     1289   1296       {ECO:0000244|PDB:3KM5}.
FT   STRAND     1302   1311       {ECO:0000244|PDB:3KM5}.
SQ   SEQUENCE   2164 AA;  233389 MW;  6DFAB22832586C63 CRC64;
     MRKLNSLFSL AVLLSLLCWG QTAAAQGGPK TAPSVTHQAV QKGIRTSKAK DLRDPIPAGM
     ARIILEAHDV WEDGTGYQML WDADHNQYGA SIPEESFWFA NGTIPAGLYD PFEYKVPVNA
     DASFSPTNFV LDGTASADIP AGTYDYVIIN PNPGIIYIVG EGVSKGNDYV VEAGKTYHFT
     VQRQGPGDAA SVVVTGEGGN EFAPVQNLQW SVSGQTVTLT WQAPASDKRT YVLNESFDTQ
     TLPNGWTMID ADGDGHNWLS TINVYNTATH TGDGAMFSKS WTASSGAKID LSPDNYLVTP
     KFTVPENGKL SYWVSSQEPW TNEHYGVFLS TTGNEAANFT IKLLEETLGS GKPAPMNLVK
     SEGVKAPAPY QERTIDLSAY AGQQVYLAFR HFGCTGIFRL YLDDVAVSGE GSSNDYTYTV
     YRDNVVIAQN LTATTFNQEN VAPGQYNYCV EVKYTAGVSP KVCKDVTVEG SNEFAPVQNL
     TGSAVGQKVT LKWDAPNGTP NPNPGTTTLS ESFENGIPAS WKTIDADGDG NNWTTTPPPG
     GSSFAGHNSA ICVSSASYIN FEGPQNPDNY LVTPELSLPN GGTLTFWVCA QDANYASEHY
     AVYASSTGND ASNFANALLE EVLTAKTVVT APEAIRGTRV QGTWYQKTVQ LPAGTKYVAF
     RHFGCTDFFW INLDDVEIKA NGKRADFTET FESSTHGEAP AEWTTIDADG DGQGWLCLSS
     GQLGWLTAHG GTNVVASFSW NGMALNPDNY LISKDVTGAT KVKYYYAVND GFPGDHYAVM
     ISKTGTNAGD FTVVFEETPN GINKGGARFG LSTEANGAKP QSVWIERTVD LPAGTKYVAF
     RHYNCSDLNY ILLDDIQFTM GGSPTPTDYT YTVYRDGTKI KEGLTETTFE EDGVATGNHE
     YCVEVKYTAG VSPKECVNVT VDPVQFNPVQ NLTGSAVGQK VTLKWDAPNG TPNPNPGTTT
     LSESFENGIP ASWKTIDADG DGNNWTTTPP PGGTSFAGHN SAICVSSASY INFEGPQNPD
     NYLVTPELSL PNGGTLTFWV CAQDANYASE HYAVYASSTG NDASNFANAL LEEVLTAKTV
     VTAPEAIRGT RVQGTWYQKT VQLPAGTKYV AFRHFGCTDF FWINLDDVEI KANGKRADFT
     ETFESSTHGE APAEWTTIDA DGDGQGWLCL SSGQLDWLTA HGGTNVVASF SWNGMALNPD
     NYLISKDVTG ATKVKYYYAV NDGFPGDHYA VMISKTGTNA GDFTVVFEET PNGINKGGAR
     FGLSTEANGA KPQSVWIERT VDLPAGTKYV AFRHYNCSDL NYILLDDIQF TMGGSPTPTD
     YTYTVYRDGT KIKEGLTETT FEEDGVATGN HEYCVEVKYT AGVSPKECVN VTVDPVQFNP
     VQNLTGSAVG QKVTLKWDAP NGTPNPNPGT TTLSESFENG IPASWKTIDA DGDGNNWTTT
     PPPGGTSFAG HNSAICVSSA SYINFEGPQN PDNYLVTPEL SLPNGGTLTF WVCAQDANYA
     SEHYAVYASS TGNDASNFAN ALLEEVLTAK TVVTAPEAIR GTRVQGTWYQ KTVQLPAGTK
     YVAFRHFGCT DFFWINLDDV EIKANGKRAD FTETFESSTH GEAPAEWTTI DADGDGQGWL
     CLSSGQLGWL TAHGGTNVVA SFSWNGMALN PDNYLISKDV TGATKVKYYY AVNDGFPGDH
     YAVMISKTGT NAGDFTVVFE ETPNGINKGG ARFGLSTEAN GAKPQSVWIE RTVDLPAGTK
     YVAFRHYNCS DLNYILLDDI QFTMGGSPTP TDYTYTVYRD GTKIKEGLTE TTFEEDGVAT
     GNHEYCVEVK YTAGVSPKEC VNVTINPTQF NPVQNLTAEQ APNSMDAILK WNAPASKRAE
     VLNEDFENGI PASWKTIDAD GDGNNWTTTP PPGGSSFAGH NSAICVSSAS YINFEGPQNP
     DNYLVTPELS LPGGGTLTFW VCAQDANYAS EHYAVYASST GNDASNFANA LLEEVLTAKT
     VVTAPEAIRG TRVQGTWYQK TVQLPAGTKY VAFRHFGCTD FFWINLDDVV ITSGNAPSYT
     YTIYRNNTQI ASGVTETTYR DPDLATGFYT YGVKVVYPNG ESAIETATLN ITSLADVTAQ
     KPYTLTVVGK TITVTCQGEA MIYDMNGRRL AAGRNTVVYT AQGGHYAVMV VVDGKSYVEK
     LAVK
//
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