ID DRD2_MOUSE Reviewed; 444 AA.
AC P61168; P13953; Q0VGH9;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 01-MAY-2013, entry version 93.
DE RecName: Full=D(2) dopamine receptor;
DE AltName: Full=Dopamine D2 receptor;
GN Name=Drd2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX PubMed=1991517; DOI=10.1016/0014-5793(91)80125-M;
RA Montmayeur J.P., Bausero P., Amlaiky N., Maroteaux L., Hen R.,
RA Borrelli E.;
RT "Differential expression of the mouse D2 dopamine receptor isoforms.";
RL FEBS Lett. 278:239-243(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=2137198; DOI=10.1038/343266a0;
RA Chio C.L., Hess G.F., Graham R.S., Huff R.M.;
RT "A second molecular form of D2 dopamine receptor in rat and bovine
RT caudate nucleus.";
RL Nature 343:266-269(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 175-270 (ISOFORM 1).
RX PubMed=2531656;
RA Dal-Toso R., Sommer B., Ewert M., Herb A., Pritchett D.B., Bach A.,
RA Shivers B.D., Seeburg P.H.;
RT "The dopamine D2 receptor: two molecular forms generated by
RT alternative splicing.";
RL EMBO J. 8:4025-4034(1989).
CC -!- FUNCTION: Dopamine receptor whose activity is mediated by G
CC proteins which inhibit adenylyl cyclase (By similarity).
CC -!- SUBUNIT: Forms homo- and heterooligomers with DRD4. The
CC interaction with DRD4 may modulate agonist-induced downstream
CC signaling. Interacts with GPRASP1, PPP1R9B, CADPS, CADPS2 and
CC CLIC6. Interacts with ARRB2 and GNAI1 (By similarity).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=Long;
CC IsoId=P61168-1, P13953-1;
CC Sequence=Displayed;
CC Name=2; Synonyms=Short;
CC IsoId=P61168-2, P13953-2;
CC Sequence=VSP_010241;
CC -!- TISSUE SPECIFICITY: Isoform 1 and isoform 2 are expressed in the
CC pituitary and brain. Isoform 1 is expressed seven times more than
CC isoform 2 in the caudate nucleus.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
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DR EMBL; X55674; CAA39209.1; -; mRNA.
DR EMBL; CH466522; EDL25723.1; -; Genomic_DNA.
DR EMBL; BC105663; AAI05664.1; -; mRNA.
DR EMBL; BC105664; AAI05665.1; -; mRNA.
DR EMBL; BC105665; AAI05666.1; -; mRNA.
DR EMBL; BC105666; AAI05667.1; -; mRNA.
DR IPI; IPI00229964; -.
DR IPI; IPI00469269; -.
DR PIR; S13921; DYMSD2.
DR RefSeq; NP_034207.2; NM_010077.2.
DR UniGene; Mm.41970; -.
DR ProteinModelPortal; P61168; -.
DR SMR; P61168; 27-444.
DR STRING; 10090.ENSMUSP00000075170; -.
DR PhosphoSite; P61168; -.
DR PRIDE; P61168; -.
DR Ensembl; ENSMUST00000075764; ENSMUSP00000075170; ENSMUSG00000032259.
DR GeneID; 13489; -.
DR KEGG; mmu:13489; -.
DR CTD; 1813; -.
DR MGI; MGI:94924; Drd2.
DR eggNOG; NOG309657; -.
DR GeneTree; ENSGT00700000104182; -.
DR HOGENOM; HOG000239242; -.
DR HOVERGEN; HBG106962; -.
DR InParanoid; Q0VGH9; -.
DR KO; K04145; -.
DR OMA; WYDDDLE; -.
DR OrthoDB; EOG4MW865; -.
DR BindingDB; P61168; -.
DR ChEMBL; CHEMBL3427; -.
DR NextBio; 284001; -.
DR Bgee; P61168; -.
DR CleanEx; MM_DRD2; -.
DR Genevestigator; P61168; -.
DR GermOnline; ENSMUSG00000032259; Mus musculus.
DR GO; GO:0001669; C:acrosomal vesicle; IEA:Compara.
DR GO; GO:0030424; C:axon; IDA:MGI.
DR GO; GO:0043679; C:axon terminus; IEA:Compara.
DR GO; GO:0030425; C:dendrite; IDA:MGI.
DR GO; GO:0030139; C:endocytic vesicle; IEA:Compara.
DR GO; GO:0005887; C:integral to plasma membrane; IEA:Compara.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:Compara.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0043204; C:perikaryon; IEA:Compara.
DR GO; GO:0014069; C:postsynaptic density; IEA:Compara.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:Compara.
DR GO; GO:0035240; F:dopamine binding; IDA:MGI.
DR GO; GO:0001591; F:dopamine neurotransmitter receptor activity, coupled via Gi/Go; IDA:MGI.
DR GO; GO:0008144; F:drug binding; IEA:Compara.
DR GO; GO:0032147; P:activation of protein kinase activity; IEA:Compara.
DR GO; GO:0021984; P:adenohypophysis development; IMP:MGI.
DR GO; GO:0007195; P:adenylate cyclase-inhibiting dopamine receptor signaling pathway; IDA:MGI.
DR GO; GO:0007628; P:adult walking behavior; IMP:MGI.
DR GO; GO:0050482; P:arachidonic acid secretion; IEA:Compara.
DR GO; GO:0031223; P:auditory behavior; IEA:Compara.
DR GO; GO:0007409; P:axonogenesis; IMP:MGI.
DR GO; GO:0048148; P:behavioral response to cocaine; IMP:MGI.
DR GO; GO:0048149; P:behavioral response to ethanol; IMP:MGI.
DR GO; GO:0048755; P:branching morphogenesis of a nerve; IMP:MGI.
DR GO; GO:0021853; P:cerebral cortex GABAergic interneuron migration; IMP:MGI.
DR GO; GO:0032922; P:circadian regulation of gene expression; IMP:MGI.
DR GO; GO:0042417; P:dopamine metabolic process; IMP:MGI.
DR GO; GO:0051482; P:elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; IEA:Compara.
DR GO; GO:0007631; P:feeding behavior; IGI:MGI.
DR GO; GO:0002031; P:G-protein coupled receptor internalization; IEA:Compara.
DR GO; GO:0007625; P:grooming behavior; IMP:MGI.
DR GO; GO:0007243; P:intracellular protein kinase cascade; IEA:Compara.
DR GO; GO:0007616; P:long-term memory; IEA:Compara.
DR GO; GO:0007194; P:negative regulation of adenylate cyclase activity; IEA:Compara.
DR GO; GO:0045776; P:negative regulation of blood pressure; IMP:MGI.
DR GO; GO:0030336; P:negative regulation of cell migration; IMP:MGI.
DR GO; GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.
DR GO; GO:0042321; P:negative regulation of circadian sleep/wake cycle, sleep; IEA:Compara.
DR GO; GO:0060160; P:negative regulation of dopamine receptor signaling pathway; IMP:MGI.
DR GO; GO:0046676; P:negative regulation of insulin secretion; IEA:Compara.
DR GO; GO:0051898; P:negative regulation of protein kinase B signaling cascade; IMP:MGI.
DR GO; GO:0050709; P:negative regulation of protein secretion; IEA:Compara.
DR GO; GO:0051967; P:negative regulation of synaptic transmission, glutamatergic; IMP:MGI.
DR GO; GO:1901386; P:negative regulation of voltage-gated calcium channel activity; IEA:Compara.
DR GO; GO:0001976; P:neurological system process involved in regulation of systemic arterial blood pressure; IMP:MGI.
DR GO; GO:0007270; P:neuron-neuron synaptic transmission; IMP:MGI.
DR GO; GO:0030432; P:peristalsis; IMP:MGI.
DR GO; GO:0046488; P:phosphatidylinositol metabolic process; IEA:Compara.
DR GO; GO:0060158; P:phospholipase C-activating dopamine receptor signaling pathway; IDA:MGI.
DR GO; GO:0043473; P:pigmentation; IMP:MGI.
DR GO; GO:0051586; P:positive regulation of dopamine uptake involved in synaptic transmission; IMP:MGI.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Compara.
DR GO; GO:0045745; P:positive regulation of G-protein coupled receptor protein signaling pathway; IEA:Compara.
DR GO; GO:0060124; P:positive regulation of growth hormone secretion; IMP:MGI.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IMP:MGI.
DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; IDA:MGI.
DR GO; GO:0002092; P:positive regulation of receptor internalization; IEA:Compara.
DR GO; GO:0035815; P:positive regulation of renal sodium excretion; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
DR GO; GO:0035810; P:positive regulation of urine volume; IMP:MGI.
DR GO; GO:0060134; P:prepulse inhibition; IMP:MGI.
DR GO; GO:0008104; P:protein localization; IMP:MGI.
DR GO; GO:0051481; P:reduction of cytosolic calcium ion concentration; IEA:Compara.
DR GO; GO:0014059; P:regulation of dopamine secretion; IMP:MGI.
DR GO; GO:0002027; P:regulation of heart rate; IMP:MGI.
DR GO; GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:MGI.
DR GO; GO:0043666; P:regulation of phosphoprotein phosphatase activity; IEA:Compara.
DR GO; GO:0043266; P:regulation of potassium ion transport; IMP:MGI.
DR GO; GO:0002028; P:regulation of sodium ion transport; IMP:MGI.
DR GO; GO:0032228; P:regulation of synaptic transmission, GABAergic; IMP:MGI.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Compara.
DR GO; GO:0001975; P:response to amphetamine; IMP:MGI.
DR GO; GO:0048678; P:response to axon injury; IEA:Compara.
DR GO; GO:0042493; P:response to drug; IDA:MGI.
DR GO; GO:0034776; P:response to histamine; IEA:Compara.
DR GO; GO:0001666; P:response to hypoxia; IEA:Compara.
DR GO; GO:0014854; P:response to inactivity; IEA:Compara.
DR GO; GO:0010039; P:response to iron ion; IEA:Compara.
DR GO; GO:0043278; P:response to morphine; IMP:MGI.
DR GO; GO:0035094; P:response to nicotine; IEA:Compara.
DR GO; GO:0009636; P:response to toxin; IEA:Compara.
DR GO; GO:0007608; P:sensory perception of smell; IMP:MGI.
DR GO; GO:0007416; P:synapse assembly; IEA:Compara.
DR GO; GO:0001963; P:synaptic transmission, dopaminergic; IEA:Compara.
DR GO; GO:0001659; P:temperature homeostasis; IMP:MGI.
DR GO; GO:0008542; P:visual learning; IMP:MGI.
DR GO; GO:0016055; P:Wnt receptor signaling pathway; IEA:Compara.
DR InterPro; IPR001922; Dopa_D2_rcpt.
DR InterPro; IPR000929; Dopamine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00567; DOPAMINED2R.
DR PRINTS; PR00242; DOPAMINER.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Complete proteome;
KW Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1 444 D(2) dopamine receptor.
FT /FTId=PRO_0000069388.
FT TOPO_DOM 1 37 Extracellular (By similarity).
FT TRANSMEM 38 60 Helical; Name=1; (By similarity).
FT TOPO_DOM 61 70 Cytoplasmic (By similarity).
FT TRANSMEM 71 93 Helical; Name=2; (By similarity).
FT TOPO_DOM 94 108 Extracellular (By similarity).
FT TRANSMEM 109 130 Helical; Name=3; (By similarity).
FT TOPO_DOM 131 151 Cytoplasmic (By similarity).
FT TRANSMEM 152 172 Helical; Name=4; (By similarity).
FT TOPO_DOM 173 188 Extracellular (By similarity).
FT TRANSMEM 189 213 Helical; Name=5; (By similarity).
FT TOPO_DOM 214 374 Cytoplasmic (By similarity).
FT TRANSMEM 375 396 Helical; Name=6; (By similarity).
FT TOPO_DOM 397 410 Extracellular (By similarity).
FT TRANSMEM 411 432 Helical; Name=7; (By similarity).
FT TOPO_DOM 433 444 Cytoplasmic (By similarity).
FT REGION 190 197 Agonist binding (By similarity).
FT REGION 211 374 Interaction with PPP1R9B (By similarity).
FT REGION 387 395 Agonist binding (By similarity).
FT BINDING 114 114 Agonist (By similarity).
FT SITE 194 194 Important for receptor activation.
FT SITE 197 197 Important for receptor activation.
FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 23 23 N-linked (GlcNAc...) (Potential).
FT DISULFID 107 182 By similarity.
FT DISULFID 400 402 By similarity.
FT VAR_SEQ 242 270 Missing (in isoform 2).
FT /FTId=VSP_010241.
FT CONFLICT 29 29 P -> A (in Ref. 1; CAA39209).
SQ SEQUENCE 444 AA; 50930 MW; 2EC8460CA11FC7F0 CRC64;
MDPLNLSWYD DDLERQNWSR PFNGSEGKPD RPHYNYYAML LTLLIFIIVF GNVLVCMAVS
REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW KFSRIHCDIF VTLDVMMCTA
SILNLCAISI DRYTAVAMPM LYNTRYSSKR RVTVMIAIVW VLSFTISCPL LFGLNNTDQN
ECIIANPAFV VYSSIVSFYV PFIVTLLVYI KIYIVLRKRR KRVNTKRSSR AFRANLKTPL
KGNCTHPEDM KLCTVIMKSN GSFPVNRRRM DAARRAQELE MEMLSSTSPP ERTRYSPIPP
SHHQLTLPDP SHHGLHSNPD SPAKPEKNGH AKIVNPRIAK FFEIQTMPNG KTRTSLKTMS
RRKLSQQKEK KATQMLAIVL GVFIICWLPF FITHILNIHC DCNIPPVLYS AFTWLGYVNS
AVNPIIYTTF NIEFRKAFMK ILHC
//
