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Database: UniProt
Entry: P61168
LinkDB: P61168
Original site: P61168 
ID   DRD2_MOUSE              Reviewed;         444 AA.
AC   P61168; P13953; Q0VGH9;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   09-JUL-2014, entry version 106.
DE   RecName: Full=D(2) dopamine receptor;
DE   AltName: Full=Dopamine D2 receptor;
GN   Name=Drd2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX   PubMed=1991517; DOI=10.1016/0014-5793(91)80125-M;
RA   Montmayeur J.P., Bausero P., Amlaiky N., Maroteaux L., Hen R.,
RA   Borrelli E.;
RT   "Differential expression of the mouse D2 dopamine receptor isoforms.";
RL   FEBS Lett. 278:239-243(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=2137198; DOI=10.1038/343266a0;
RA   Chio C.L., Hess G.F., Graham R.S., Huff R.M.;
RT   "A second molecular form of D2 dopamine receptor in rat and bovine
RT   caudate nucleus.";
RL   Nature 343:266-269(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 175-270 (ISOFORM 1).
RX   PubMed=2531656;
RA   Dal-Toso R., Sommer B., Ewert M., Herb A., Pritchett D.B., Bach A.,
RA   Shivers B.D., Seeburg P.H.;
RT   "The dopamine D2 receptor: two molecular forms generated by
RT   alternative splicing.";
RL   EMBO J. 8:4025-4034(1989).
CC   -!- FUNCTION: Dopamine receptor whose activity is mediated by G
CC       proteins which inhibit adenylyl cyclase (By similarity).
CC   -!- SUBUNIT: Forms homo- and heterooligomers with DRD4. The
CC       interaction with DRD4 may modulate agonist-induced downstream
CC       signaling. Interacts with GPRASP1, PPP1R9B, CADPS, CADPS2 and
CC       CLIC6. Interacts with ARRB2, HTR2A and GNAI1 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=Long;
CC         IsoId=P61168-1, P13953-1;
CC         Sequence=Displayed;
CC       Name=2; Synonyms=Short;
CC         IsoId=P61168-2, P13953-2;
CC         Sequence=VSP_010241;
CC   -!- TISSUE SPECIFICITY: Isoform 1 and isoform 2 are expressed in the
CC       pituitary and brain. Isoform 1 is expressed seven times more than
CC       isoform 2 in the caudate nucleus.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
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DR   EMBL; X55674; CAA39209.1; -; mRNA.
DR   EMBL; CH466522; EDL25723.1; -; Genomic_DNA.
DR   EMBL; BC105663; AAI05664.1; -; mRNA.
DR   EMBL; BC105664; AAI05665.1; -; mRNA.
DR   EMBL; BC105665; AAI05666.1; -; mRNA.
DR   EMBL; BC105666; AAI05667.1; -; mRNA.
DR   CCDS; CCDS40615.1; -.
DR   PIR; S13921; DYMSD2.
DR   RefSeq; NP_034207.2; NM_010077.2. [P61168-1]
DR   RefSeq; XP_006510059.1; XM_006509996.1. [P61168-2]
DR   UniGene; Mm.41970; -.
DR   ProteinModelPortal; P61168; -.
DR   SMR; P61168; 37-444.
DR   BioGrid; 199306; 1.
DR   IntAct; P61168; 4.
DR   MINT; MINT-5313868; -.
DR   STRING; 10090.ENSMUSP00000075170; -.
DR   BindingDB; P61168; -.
DR   ChEMBL; CHEMBL3427; -.
DR   GuidetoPHARMACOLOGY; 215; -.
DR   PhosphoSite; P61168; -.
DR   PRIDE; P61168; -.
DR   Ensembl; ENSMUST00000075764; ENSMUSP00000075170; ENSMUSG00000032259. [P61168-1]
DR   GeneID; 13489; -.
DR   KEGG; mmu:13489; -.
DR   UCSC; uc009pja.1; mouse.
DR   CTD; 1813; -.
DR   MGI; MGI:94924; Drd2.
DR   eggNOG; NOG309657; -.
DR   GeneTree; ENSGT00750000117240; -.
DR   HOGENOM; HOG000239242; -.
DR   HOVERGEN; HBG106962; -.
DR   InParanoid; Q0VGH9; -.
DR   KO; K04145; -.
DR   OMA; RNWSRPF; -.
DR   OrthoDB; EOG769ZMG; -.
DR   TreeFam; TF334382; -.
DR   NextBio; 284001; -.
DR   PRO; PR:P61168; -.
DR   Bgee; P61168; -.
DR   CleanEx; MM_DRD2; -.
DR   Genevestigator; P61168; -.
DR   GO; GO:0001669; C:acrosomal vesicle; IEA:Ensembl.
DR   GO; GO:0030424; C:axon; IDA:MGI.
DR   GO; GO:0043679; C:axon terminus; IEA:Ensembl.
DR   GO; GO:0030425; C:dendrite; IDA:MGI.
DR   GO; GO:0043197; C:dendritic spine; IEA:Ensembl.
DR   GO; GO:0030139; C:endocytic vesicle; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0016328; C:lateral plasma membrane; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IDA:MGI.
DR   GO; GO:0043204; C:perikaryon; IEA:Ensembl.
DR   GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR   GO; GO:0036126; C:sperm flagellum; IEA:Ensembl.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IEA:Ensembl.
DR   GO; GO:0004935; F:adrenergic receptor activity; IEA:InterPro.
DR   GO; GO:0035240; F:dopamine binding; IDA:MGI.
DR   GO; GO:0004952; F:dopamine neurotransmitter receptor activity; IDA:MGI.
DR   GO; GO:0001591; F:dopamine neurotransmitter receptor activity, coupled via Gi/Go; IDA:MGI.
DR   GO; GO:0008144; F:drug binding; IEA:Ensembl.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; IDA:MGI.
DR   GO; GO:0032147; P:activation of protein kinase activity; IEA:Ensembl.
DR   GO; GO:0021984; P:adenohypophysis development; IMP:MGI.
DR   GO; GO:0007195; P:adenylate cyclase-inhibiting dopamine receptor signaling pathway; IDA:MGI.
DR   GO; GO:0030534; P:adult behavior; IMP:MGI.
DR   GO; GO:0007628; P:adult walking behavior; IMP:MGI.
DR   GO; GO:0050482; P:arachidonic acid secretion; IEA:Ensembl.
DR   GO; GO:0008306; P:associative learning; IMP:MGI.
DR   GO; GO:0031223; P:auditory behavior; IEA:Ensembl.
DR   GO; GO:0007409; P:axonogenesis; IMP:MGI.
DR   GO; GO:0048148; P:behavioral response to cocaine; IMP:MGI.
DR   GO; GO:0048149; P:behavioral response to ethanol; IMP:MGI.
DR   GO; GO:0048755; P:branching morphogenesis of a nerve; IMP:MGI.
DR   GO; GO:0021853; P:cerebral cortex GABAergic interneuron migration; IMP:MGI.
DR   GO; GO:0032922; P:circadian regulation of gene expression; IMP:MGI.
DR   GO; GO:0042417; P:dopamine metabolic process; IMP:MGI.
DR   GO; GO:0007212; P:dopamine receptor signaling pathway; IGI:MGI.
DR   GO; GO:0007631; P:feeding behavior; IGI:MGI.
DR   GO; GO:0002031; P:G-protein coupled receptor internalization; IEA:Ensembl.
DR   GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:MGI.
DR   GO; GO:0007625; P:grooming behavior; IMP:MGI.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
DR   GO; GO:0007626; P:locomotory behavior; IMP:MGI.
DR   GO; GO:0007616; P:long-term memory; IEA:Ensembl.
DR   GO; GO:0007194; P:negative regulation of adenylate cyclase activity; IEA:Ensembl.
DR   GO; GO:0045776; P:negative regulation of blood pressure; IMP:MGI.
DR   GO; GO:0030336; P:negative regulation of cell migration; IMP:MGI.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.
DR   GO; GO:0042321; P:negative regulation of circadian sleep/wake cycle, sleep; IEA:Ensembl.
DR   GO; GO:0051481; P:negative regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0060160; P:negative regulation of dopamine receptor signaling pathway; IMP:MGI.
DR   GO; GO:0033602; P:negative regulation of dopamine secretion; IEA:Ensembl.
DR   GO; GO:0046676; P:negative regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0051898; P:negative regulation of protein kinase B signaling; IMP:MGI.
DR   GO; GO:0050709; P:negative regulation of protein secretion; IEA:Ensembl.
DR   GO; GO:0051967; P:negative regulation of synaptic transmission, glutamatergic; IMP:MGI.
DR   GO; GO:1901386; P:negative regulation of voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0001976; P:neurological system process involved in regulation of systemic arterial blood pressure; IMP:MGI.
DR   GO; GO:0007270; P:neuron-neuron synaptic transmission; IMP:MGI.
DR   GO; GO:0021769; P:orbitofrontal cortex development; IEA:Ensembl.
DR   GO; GO:0030432; P:peristalsis; IMP:MGI.
DR   GO; GO:0046488; P:phosphatidylinositol metabolic process; IEA:Ensembl.
DR   GO; GO:0060158; P:phospholipase C-activating dopamine receptor signaling pathway; IDA:MGI.
DR   GO; GO:0043473; P:pigmentation; IMP:MGI.
DR   GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; IEA:Ensembl.
DR   GO; GO:0051586; P:positive regulation of dopamine uptake involved in synaptic transmission; IMP:MGI.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR   GO; GO:0045745; P:positive regulation of G-protein coupled receptor protein signaling pathway; IEA:Ensembl.
DR   GO; GO:0060124; P:positive regulation of growth hormone secretion; IMP:MGI.
DR   GO; GO:1900273; P:positive regulation of long-term synaptic potentiation; IEA:Ensembl.
DR   GO; GO:0040018; P:positive regulation of multicellular organism growth; IMP:MGI.
DR   GO; GO:0002052; P:positive regulation of neuroblast proliferation; IDA:MGI.
DR   GO; GO:0002092; P:positive regulation of receptor internalization; IEA:Ensembl.
DR   GO; GO:0035815; P:positive regulation of renal sodium excretion; IMP:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0035810; P:positive regulation of urine volume; IMP:MGI.
DR   GO; GO:0060134; P:prepulse inhibition; IMP:MGI.
DR   GO; GO:0008104; P:protein localization; IMP:MGI.
DR   GO; GO:0014059; P:regulation of dopamine secretion; IMP:MGI.
DR   GO; GO:0051584; P:regulation of dopamine uptake involved in synaptic transmission; IMP:MGI.
DR   GO; GO:0002027; P:regulation of heart rate; IMP:MGI.
DR   GO; GO:0090325; P:regulation of locomotion involved in locomotory behavior; IEA:Ensembl.
DR   GO; GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:MGI.
DR   GO; GO:0043666; P:regulation of phosphoprotein phosphatase activity; IEA:Ensembl.
DR   GO; GO:0043266; P:regulation of potassium ion transport; IMP:MGI.
DR   GO; GO:0002028; P:regulation of sodium ion transport; IMP:MGI.
DR   GO; GO:0051823; P:regulation of synapse structural plasticity; IEA:Ensembl.
DR   GO; GO:0050804; P:regulation of synaptic transmission; IMP:MGI.
DR   GO; GO:0032228; P:regulation of synaptic transmission, GABAergic; IMP:MGI.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR   GO; GO:0001975; P:response to amphetamine; IMP:MGI.
DR   GO; GO:0048678; P:response to axon injury; IEA:Ensembl.
DR   GO; GO:0042220; P:response to cocaine; IDA:MGI.
DR   GO; GO:0042493; P:response to drug; IDA:MGI.
DR   GO; GO:0034776; P:response to histamine; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0014854; P:response to inactivity; IEA:Ensembl.
DR   GO; GO:0010039; P:response to iron ion; IEA:Ensembl.
DR   GO; GO:0009416; P:response to light stimulus; IMP:MGI.
DR   GO; GO:0043278; P:response to morphine; IMP:MGI.
DR   GO; GO:0035094; P:response to nicotine; IEA:Ensembl.
DR   GO; GO:0009636; P:response to toxic substance; IEA:Ensembl.
DR   GO; GO:0007608; P:sensory perception of smell; IMP:MGI.
DR   GO; GO:0001964; P:startle response; IMP:MGI.
DR   GO; GO:0021756; P:striatum development; IEA:Ensembl.
DR   GO; GO:0007416; P:synapse assembly; IEA:Ensembl.
DR   GO; GO:0001963; P:synaptic transmission, dopaminergic; IEA:Ensembl.
DR   GO; GO:0001659; P:temperature homeostasis; IMP:MGI.
DR   GO; GO:0008542; P:visual learning; IMP:MGI.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:Ensembl.
DR   Gene3D; 1.20.1070.10; -; 2.
DR   InterPro; IPR001922; Dopamine_D2_rcpt.
DR   InterPro; IPR000929; Dopamine_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00567; DOPAMINED2R.
DR   PRINTS; PR00242; DOPAMINER.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell membrane; Complete proteome;
KW   Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN         1    444       D(2) dopamine receptor.
FT                                /FTId=PRO_0000069388.
FT   TOPO_DOM      1     37       Extracellular (By similarity).
FT   TRANSMEM     38     60       Helical; Name=1; (By similarity).
FT   TOPO_DOM     61     70       Cytoplasmic (By similarity).
FT   TRANSMEM     71     93       Helical; Name=2; (By similarity).
FT   TOPO_DOM     94    108       Extracellular (By similarity).
FT   TRANSMEM    109    130       Helical; Name=3; (By similarity).
FT   TOPO_DOM    131    151       Cytoplasmic (By similarity).
FT   TRANSMEM    152    172       Helical; Name=4; (By similarity).
FT   TOPO_DOM    173    188       Extracellular (By similarity).
FT   TRANSMEM    189    213       Helical; Name=5; (By similarity).
FT   TOPO_DOM    214    374       Cytoplasmic (By similarity).
FT   TRANSMEM    375    396       Helical; Name=6; (By similarity).
FT   TOPO_DOM    397    410       Extracellular (By similarity).
FT   TRANSMEM    411    432       Helical; Name=7; (By similarity).
FT   TOPO_DOM    433    444       Cytoplasmic (By similarity).
FT   REGION      190    197       Agonist binding (By similarity).
FT   REGION      211    374       Interaction with PPP1R9B (By similarity).
FT   REGION      387    395       Agonist binding (By similarity).
FT   BINDING     114    114       Agonist (By similarity).
FT   SITE        194    194       Important for receptor activation.
FT   SITE        197    197       Important for receptor activation.
FT   CARBOHYD      5      5       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     17     17       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     23     23       N-linked (GlcNAc...) (Potential).
FT   DISULFID    107    182       By similarity.
FT   DISULFID    400    402       By similarity.
FT   VAR_SEQ     242    270       Missing (in isoform 2).
FT                                /FTId=VSP_010241.
FT   CONFLICT     29     29       P -> A (in Ref. 1; CAA39209).
SQ   SEQUENCE   444 AA;  50930 MW;  2EC8460CA11FC7F0 CRC64;
     MDPLNLSWYD DDLERQNWSR PFNGSEGKPD RPHYNYYAML LTLLIFIIVF GNVLVCMAVS
     REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW KFSRIHCDIF VTLDVMMCTA
     SILNLCAISI DRYTAVAMPM LYNTRYSSKR RVTVMIAIVW VLSFTISCPL LFGLNNTDQN
     ECIIANPAFV VYSSIVSFYV PFIVTLLVYI KIYIVLRKRR KRVNTKRSSR AFRANLKTPL
     KGNCTHPEDM KLCTVIMKSN GSFPVNRRRM DAARRAQELE MEMLSSTSPP ERTRYSPIPP
     SHHQLTLPDP SHHGLHSNPD SPAKPEKNGH AKIVNPRIAK FFEIQTMPNG KTRTSLKTMS
     RRKLSQQKEK KATQMLAIVL GVFIICWLPF FITHILNIHC DCNIPPVLYS AFTWLGYVNS
     AVNPIIYTTF NIEFRKAFMK ILHC
//
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