ID RL23A_HUMAN Reviewed; 156 AA.
AC P62750; B2R5B2; P29316; P39024; Q92774;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 29-MAY-2013, entry version 103.
DE RecName: Full=60S ribosomal protein L23a;
GN Name=RPL23A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Melanoma;
RA Jiang H., Lin J., Tao J., Fisher P.B.;
RL Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RA Reddy K.B., Lin C.W., Howe P.H.;
RL Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8662070; DOI=10.1007/s002510050095;
RA Fan W., Cai W., Parimoo S., Lennon G.G., Weissman S.M.;
RT "Identification of seven new human MHC class I region genes around the
RT HLA-F locus.";
RL Immunogenetics 44:97-103(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9417910; DOI=10.1006/geno.1997.5038;
RA Fan W., Christensen M., Eichler E., Zhang X., Lennon G.;
RT "Cloning, sequencing, gene organization, and localization of the human
RT ribosomal protein RPL23A gene.";
RL Genomics 46:234-239(1997).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Adrenal gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 10-156.
RC TISSUE=Liver;
RA Bonaldo M., Soares M.B.;
RT "Identification and localization of six liver expressed genes on human
RT chromosome 13.";
RL Submitted (JUL-1993) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,
RA Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in
RT signaling networks.";
RL Cell 127:635-648(2006).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-45, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [13]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA Blagoev B.;
RT "System-wide temporal characterization of the proteome and
RT phosphoproteome of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [14]
RP VARIANT THR-99.
RX PubMed=22431104; DOI=10.1002/humu.22081;
RA Gazda H.T., Preti M., Sheen M.R., O'Donohue M.F., Vlachos A.,
RA Davies S.M., Kattamis A., Doherty L., Landowski M., Buros C.,
RA Ghazvinian R., Sieff C.A., Newburger P.E., Niewiadomska E.,
RA Matysiak M., Glader B., Atsidaftos E., Lipton J.M., Gleizes P.E.,
RA Beggs A.H.;
RT "Frameshift mutation in p53 regulator RPL26 is associated with
RT multiple physical abnormalities and a specific pre-ribosomal RNA
RT processing defect in diamond-blackfan anemia.";
RL Hum. Mutat. 33:1037-1044(2012).
CC -!- FUNCTION: This protein binds to a specific region on the 26S rRNA
CC (By similarity).
CC -!- INTERACTION:
CC P62633:CNBP; NbExp=1; IntAct=EBI-353254, EBI-1047529;
CC Q9NY93:DDX56; NbExp=1; IntAct=EBI-353254, EBI-372376;
CC Q9NX58:LYAR; NbExp=1; IntAct=EBI-353254, EBI-713507;
CC O15479:MAGEB2; NbExp=1; IntAct=EBI-353254, EBI-1057615;
CC Q9UKS6:PACSIN3; NbExp=1; IntAct=EBI-353254, EBI-77926;
CC Q96BK5:PINX1; NbExp=1; IntAct=EBI-353254, EBI-721782;
CC O43586:PSTPIP1; NbExp=1; IntAct=EBI-353254, EBI-1050964;
CC O00442:RTCD1; NbExp=1; IntAct=EBI-353254, EBI-1045306;
CC -!- PTM: N-terminus is methylated by METTL11A/NTM1 (By similarity).
CC -!- SIMILARITY: Belongs to the ribosomal protein L23P family.
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DR EMBL; U43701; AAB03210.1; -; mRNA.
DR EMBL; U02032; AAA03341.1; -; mRNA.
DR EMBL; U37230; AAB17510.1; -; mRNA.
DR EMBL; AF001689; AAC51934.1; -; Genomic_DNA.
DR EMBL; AK312123; BAG35059.1; -; mRNA.
DR EMBL; CH471159; EAW51132.1; -; Genomic_DNA.
DR EMBL; BC014459; AAH14459.1; -; mRNA.
DR EMBL; BC058041; AAH58041.1; -; mRNA.
DR EMBL; L13799; AAA35681.1; -; mRNA.
DR IPI; IPI00021266; -.
DR RefSeq; NP_000975.2; NM_000984.5.
DR UniGene; Hs.419463; -.
DR ProteinModelPortal; P62750; -.
DR IntAct; P62750; 15.
DR MINT; MINT-4999907; -.
DR STRING; 9606.ENSP00000389103; -.
DR PhosphoSite; P62750; -.
DR DMDM; 51338637; -.
DR SWISS-2DPAGE; P62750; -.
DR PaxDb; P62750; -.
DR PRIDE; P62750; -.
DR Ensembl; ENST00000422514; ENSP00000389103; ENSG00000198242.
DR GeneID; 6147; -.
DR KEGG; hsa:6147; -.
DR UCSC; uc002hci.3; human.
DR CTD; 6147; -.
DR GeneCards; GC17P027046; -.
DR H-InvDB; HIX0016623; -.
DR HGNC; HGNC:10317; RPL23A.
DR HPA; HPA051754; -.
DR MIM; 602326; gene.
DR neXtProt; NX_P62750; -.
DR PharmGKB; PA34691; -.
DR eggNOG; COG0089; -.
DR HOGENOM; HOG000231365; -.
DR HOVERGEN; HBG056619; -.
DR KO; K02893; -.
DR OrthoDB; EOG43JC62; -.
DR PhylomeDB; P62750; -.
DR Reactome; REACT_116125; Disease.
DR Reactome; REACT_17015; Metabolism of proteins.
DR Reactome; REACT_1762; 3' -UTR-mediated translational regulation.
DR Reactome; REACT_21257; Metabolism of RNA.
DR Reactome; REACT_71; Gene Expression.
DR ChiTaRS; RPL23A; human.
DR GenomeRNAi; 6147; -.
DR NextBio; 23883; -.
DR ArrayExpress; P62750; -.
DR Bgee; P62750; -.
DR CleanEx; HS_RPL23A; -.
DR Genevestigator; P62750; -.
DR GermOnline; ENSG00000198242; Homo sapiens.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; NAS:UniProtKB.
DR GO; GO:0008283; P:cell proliferation; IMP:UniProtKB.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
DR GO; GO:0006414; P:translational elongation; TAS:Reactome.
DR GO; GO:0006413; P:translational initiation; TAS:Reactome.
DR GO; GO:0006415; P:translational termination; TAS:Reactome.
DR GO; GO:0019083; P:viral transcription; TAS:Reactome.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait.
DR InterPro; IPR019985; Ribosomal_L23.
DR InterPro; IPR012678; Ribosomal_L23/L15e_core_dom.
DR InterPro; IPR001014; Ribosomal_L23/L25_CS.
DR InterPro; IPR005633; Ribosomal_L23/L25_N.
DR InterPro; IPR013025; Ribosomal_L25/23.
DR Pfam; PF00276; Ribosomal_L23; 1.
DR Pfam; PF03939; Ribosomal_L23eN; 1.
DR SUPFAM; SSF54189; L23_L15e_core; 1.
DR TIGRFAMs; TIGR03636; L23_arch; 1.
DR PROSITE; PS00050; RIBOSOMAL_L23; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Methylation; Phosphoprotein; Polymorphism;
KW Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding;
KW rRNA-binding.
FT INIT_MET 1 1 Removed (By similarity).
FT CHAIN 2 156 60S ribosomal protein L23a.
FT /FTId=PRO_0000129467.
FT MOD_RES 2 2 N,N,N-trimethylalanine (By similarity).
FT MOD_RES 45 45 Phosphothreonine.
FT VARIANT 99 99 I -> T (rare variant found in Diamond-
FT Blackfan anemia patients; unknown
FT pathological significance).
FT /FTId=VAR_069221.
FT CONFLICT 1 2 MA -> IP (in Ref. 2; AAA03341).
FT CONFLICT 78 78 K -> N (in Ref. 3; AAB17510).
FT CONFLICT 110 110 K -> S (in Ref. 3; AAB17510).
SQ SEQUENCE 156 AA; 17695 MW; 3980E77B47FAB70E CRC64;
MAPKAKKEAP APPKAEAKAK ALKAKKAVLK GVHSHKKKKI RTSPTFRRPK TLRLRRQPKY
PRKSAPRRNK LDHYAIIKFP LTTESAMKKI EDNNTLVFIV DVKANKHQIK QAVKKLYDID
VAKVNTLIRP DGEKKAYVRL APDYDALDVA NKIGII
//
