ID GBRB3_RAT Reviewed; 473 AA.
AC P63079; P15433;
DT 13-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 01-MAY-2013, entry version 77.
DE RecName: Full=Gamma-aminobutyric acid receptor subunit beta-3;
DE AltName: Full=GABA(A) receptor subunit beta-3;
DE Flags: Precursor;
GN Name=Gabrb3; Synonyms=Gabrb-3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain;
RX PubMed=2548852;
RA Ymer S., Schofield P.R., Draguhn A., Werner P., Koehler M.,
RA Seeburg P.H.;
RT "GABAA receptor beta subunit heterogeneity: functional expression of
RT cloned cDNAs.";
RL EMBO J. 8:1665-1670(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=2540033; DOI=10.1016/0014-5793(89)80271-6;
RA Lolait S.J., O'Carroll A.-M., Kusano K., Muller J.-M.,
RA Brownstein M.J., Mahan L.C.;
RT "Cloning and expression of a novel rat GABAA receptor.";
RL FEBS Lett. 246:145-148(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-80.
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=8382702;
RA Kirkness E.F., Fraser C.M.;
RT "A strong promoter element is located between alternative exons of a
RT gene encoding the human gamma-aminobutyric acid-type A receptor beta 3
RT subunit (GABRB3).";
RL J. Biol. Chem. 268:4420-4428(1993).
RN [4]
RP INTERACTION WITH UBQLN1.
RC STRAIN=Sprague-Dawley; TISSUE=Hippocampus;
RX PubMed=11528422; DOI=10.1038/nn0901-908;
RA Bedford F.K., Kittler J.T., Muller E., Thomas P., Uren J.M., Merlo D.,
RA Wisden W., Triller A., Smart T.G., Moss S.J.;
RT "GABA(A) receptor cell surface number and subunit stability are
RT regulated by the ubiquitin-like protein Plic-1.";
RL Nat. Neurosci. 4:908-916(2001).
CC -!- FUNCTION: GABA, the major inhibitory neurotransmitter in the
CC vertebrate brain, mediates neuronal inhibition by binding to the
CC GABA/benzodiazepine receptor and opening an integral chloride
CC channel.
CC -!- SUBUNIT: Generally pentameric. There are five types of GABA(A)
CC receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1.
CC -!- INTERACTION:
CC Q7TSU1:Arfgef2; NbExp=3; IntAct=EBI-6257937, EBI-6257913;
CC -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
CC membrane; Multi-pass membrane protein. Cell membrane; Multi-pass
CC membrane protein.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
CC GABRB3 sub-subfamily.
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DR EMBL; X15468; CAA33495.1; -; mRNA.
DR EMBL; L04310; AAA41180.1; -; Genomic_DNA.
DR IPI; IPI00327083; -.
DR PIR; S04466; S04466.
DR RefSeq; NP_058761.1; NM_017065.1.
DR UniGene; Rn.208228; -.
DR ProteinModelPortal; P63079; -.
DR SMR; P63079; 47-346.
DR IntAct; P63079; 2.
DR STRING; 10116.ENSRNOP00000061969; -.
DR PaxDb; P63079; -.
DR PRIDE; P63079; -.
DR GeneID; 24922; -.
DR KEGG; rno:24922; -.
DR UCSC; RGD:2651; rat.
DR CTD; 2562; -.
DR RGD; 2651; Gabrb3.
DR eggNOG; NOG77438; -.
DR HOGENOM; HOG000231335; -.
DR HOVERGEN; HBG051707; -.
DR InParanoid; P63079; -.
DR KO; K05181; -.
DR BindingDB; P63079; -.
DR ChEMBL; CHEMBL316; -.
DR NextBio; 285953; -.
DR ArrayExpress; P63079; -.
DR Genevestigator; P63079; -.
DR GermOnline; ENSRNOG00000014938; Rattus norvegicus.
DR GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0060077; C:inhibitory synapse; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043195; C:terminal bouton; IDA:RGD.
DR GO; GO:0005254; F:chloride channel activity; IDA:RGD.
DR GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR GO; GO:0004890; F:GABA-A receptor activity; IDA:RGD.
DR GO; GO:0051932; P:synaptic transmission, GABAergic; IDA:RGD.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006028; GABAA_rcpt.
DR InterPro; IPR002289; GABAAb_rcpt.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR01160; GABAARBETA.
DR PRINTS; PR00253; GABAARECEPTR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neu_channel_TM; 1.
DR SUPFAM; SSF63712; Neur_chan_LBD; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 1: Evidence at protein level;
KW Cell junction; Cell membrane; Chloride; Chloride channel;
KW Complete proteome; Disulfide bond; Glycoprotein; Ion channel;
KW Ion transport; Ligand-gated ion channel; Membrane;
KW Postsynaptic cell membrane; Receptor; Reference proteome; Signal;
KW Synapse; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1 25 Potential.
FT CHAIN 26 473 Gamma-aminobutyric acid receptor subunit
FT beta-3.
FT /FTId=PRO_0000000464.
FT TOPO_DOM 26 245 Extracellular (Probable).
FT TRANSMEM 246 267 Helical; (Probable).
FT TRANSMEM 271 293 Helical; (Probable).
FT TRANSMEM 305 327 Helical; (Probable).
FT TOPO_DOM 328 450 Cytoplasmic (Probable).
FT TRANSMEM 451 472 Helical; (Probable).
FT CARBOHYD 33 33 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 105 105 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 174 174 N-linked (GlcNAc...) (Potential).
FT DISULFID 161 175 By similarity.
FT CONFLICT 256 256 L -> M (in Ref. 1; CAA33495).
SQ SEQUENCE 473 AA; 54166 MW; 6A5ABD8A9143FE45 CRC64;
MWGFAGGRLF GIFSAPVLVA VVCCAQSVND PGNMSFVKET VDKLLKGYDI RLRPDFGGPP
VCVGMNIDIA SIDMVSEVNM DYTLTMYFQQ YWRDKRLAYS GIPLNLTLDN RVADQLWVPD
TYFLNDKKSF VHGVTVKNRM IRLHPDGTVL YGLRITTTAA CMMDLRRYPL DEQNCTLEIE
SYGYTTDDIE FYWRGGDKAV TGVERIELPQ FSIVEHRLVS RNVVFATGAY PRLSLSFRLK
RNIGYFILQT YMPSILITIL SWVSFWINYD ASAARVALGI TTVLTMTTIN THLRETLPKI
PYVKAIDMYL MGCFVFVFLA LLEYAFVNYI FFGRGPQRQK KLAEKTAKAK NDRSKSEINR
VDAHGNILLA PMDVHNEMNE VAGSVGDTRN SAISFDNSGI QYRKQSMPKE GHGRYMGDRS
IPHKKTHLRR RSSQLKIKIP DLTDVNAIDR WSRIVFPFTF SLFNLVYWLY YVN
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