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Database: UniProt
Entry: P63079
LinkDB: P63079
Original site: P63079 
ID   GBRB3_RAT               Reviewed;         473 AA.
AC   P63079; P15433;
DT   13-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   19-MAR-2014, entry version 85.
DE   RecName: Full=Gamma-aminobutyric acid receptor subunit beta-3;
DE   AltName: Full=GABA(A) receptor subunit beta-3;
DE   Flags: Precursor;
GN   Name=Gabrb3; Synonyms=Gabrb-3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain;
RX   PubMed=2548852;
RA   Ymer S., Schofield P.R., Draguhn A., Werner P., Koehler M.,
RA   Seeburg P.H.;
RT   "GABAA receptor beta subunit heterogeneity: functional expression of
RT   cloned cDNAs.";
RL   EMBO J. 8:1665-1670(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=2540033; DOI=10.1016/0014-5793(89)80271-6;
RA   Lolait S.J., O'Carroll A.-M., Kusano K., Muller J.-M.,
RA   Brownstein M.J., Mahan L.C.;
RT   "Cloning and expression of a novel rat GABAA receptor.";
RL   FEBS Lett. 246:145-148(1989).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-80.
RC   STRAIN=Sprague-Dawley; TISSUE=Liver;
RX   PubMed=8382702;
RA   Kirkness E.F., Fraser C.M.;
RT   "A strong promoter element is located between alternative exons of a
RT   gene encoding the human gamma-aminobutyric acid-type A receptor beta 3
RT   subunit (GABRB3).";
RL   J. Biol. Chem. 268:4420-4428(1993).
RN   [4]
RP   INTERACTION WITH UBQLN1.
RC   STRAIN=Sprague-Dawley; TISSUE=Hippocampus;
RX   PubMed=11528422; DOI=10.1038/nn0901-908;
RA   Bedford F.K., Kittler J.T., Muller E., Thomas P., Uren J.M., Merlo D.,
RA   Wisden W., Triller A., Smart T.G., Moss S.J.;
RT   "GABA(A) receptor cell surface number and subunit stability are
RT   regulated by the ubiquitin-like protein Plic-1.";
RL   Nat. Neurosci. 4:908-916(2001).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=16641100; DOI=10.1073/pnas.0600895103;
RA   Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.;
RT   "Quantitative phosphoproteomics of vasopressin-sensitive renal cells:
RT   regulation of aquaporin-2 phosphorylation at two sites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
CC   -!- FUNCTION: GABA, the major inhibitory neurotransmitter in the
CC       vertebrate brain, mediates neuronal inhibition by binding to the
CC       GABA/benzodiazepine receptor and opening an integral chloride
CC       channel.
CC   -!- SUBUNIT: Generally pentameric. There are five types of GABA(A)
CC       receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1.
CC   -!- INTERACTION:
CC       Q7TSU1:Arfgef2; NbExp=3; IntAct=EBI-6257937, EBI-6257913;
CC   -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
CC       membrane; Multi-pass membrane protein. Cell membrane; Multi-pass
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
CC       GABRB3 sub-subfamily.
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DR   EMBL; X15468; CAA33495.1; -; mRNA.
DR   EMBL; L04310; AAA41180.1; -; Genomic_DNA.
DR   PIR; S04466; S04466.
DR   RefSeq; NP_058761.1; NM_017065.1.
DR   UniGene; Rn.233948; -.
DR   ProteinModelPortal; P63079; -.
DR   SMR; P63079; 37-473.
DR   IntAct; P63079; 2.
DR   STRING; 10116.ENSRNOP00000061969; -.
DR   BindingDB; P63079; -.
DR   ChEMBL; CHEMBL1907607; -.
DR   PaxDb; P63079; -.
DR   PRIDE; P63079; -.
DR   GeneID; 24922; -.
DR   KEGG; rno:24922; -.
DR   UCSC; RGD:2651; rat.
DR   CTD; 2562; -.
DR   RGD; 2651; Gabrb3.
DR   eggNOG; NOG77438; -.
DR   HOGENOM; HOG000231335; -.
DR   HOVERGEN; HBG051707; -.
DR   InParanoid; P63079; -.
DR   KO; K05181; -.
DR   NextBio; 285953; -.
DR   PRO; PR:P63079; -.
DR   Genevestigator; P63079; -.
DR   GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0060077; C:inhibitory synapse; IDA:MGI.
DR   GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043195; C:terminal bouton; IDA:RGD.
DR   GO; GO:0005254; F:chloride channel activity; IDA:RGD.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   GO; GO:0004890; F:GABA-A receptor activity; IDA:RGD.
DR   GO; GO:0051932; P:synaptic transmission, GABAergic; IDA:RGD.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006028; GABAA_rcpt.
DR   InterPro; IPR002289; GABAAb_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR01160; GABAARBETA.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   TIGRFAMs; TIGR00860; LIC; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   1: Evidence at protein level;
KW   Cell junction; Cell membrane; Chloride; Chloride channel;
KW   Complete proteome; Disulfide bond; Glycoprotein; Ion channel;
KW   Ion transport; Ligand-gated ion channel; Membrane;
KW   Postsynaptic cell membrane; Receptor; Reference proteome; Signal;
KW   Synapse; Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL        1     25       Potential.
FT   CHAIN        26    473       Gamma-aminobutyric acid receptor subunit
FT                                beta-3.
FT                                /FTId=PRO_0000000464.
FT   TOPO_DOM     26    245       Extracellular (Probable).
FT   TRANSMEM    246    267       Helical; (Probable).
FT   TRANSMEM    271    293       Helical; (Probable).
FT   TRANSMEM    305    327       Helical; (Probable).
FT   TOPO_DOM    328    450       Cytoplasmic (Probable).
FT   TRANSMEM    451    472       Helical; (Probable).
FT   CARBOHYD     33     33       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    105    105       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    174    174       N-linked (GlcNAc...) (Potential).
FT   DISULFID    161    175       By similarity.
FT   CONFLICT    256    256       L -> M (in Ref. 1; CAA33495).
SQ   SEQUENCE   473 AA;  54166 MW;  6A5ABD8A9143FE45 CRC64;
     MWGFAGGRLF GIFSAPVLVA VVCCAQSVND PGNMSFVKET VDKLLKGYDI RLRPDFGGPP
     VCVGMNIDIA SIDMVSEVNM DYTLTMYFQQ YWRDKRLAYS GIPLNLTLDN RVADQLWVPD
     TYFLNDKKSF VHGVTVKNRM IRLHPDGTVL YGLRITTTAA CMMDLRRYPL DEQNCTLEIE
     SYGYTTDDIE FYWRGGDKAV TGVERIELPQ FSIVEHRLVS RNVVFATGAY PRLSLSFRLK
     RNIGYFILQT YMPSILITIL SWVSFWINYD ASAARVALGI TTVLTMTTIN THLRETLPKI
     PYVKAIDMYL MGCFVFVFLA LLEYAFVNYI FFGRGPQRQK KLAEKTAKAK NDRSKSEINR
     VDAHGNILLA PMDVHNEMNE VAGSVGDTRN SAISFDNSGI QYRKQSMPKE GHGRYMGDRS
     IPHKKTHLRR RSSQLKIKIP DLTDVNAIDR WSRIVFPFTF SLFNLVYWLY YVN
//
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