ID Y873_MYCTU Reviewed; 650 AA.
AC P63429; L0T558; O53885; Q10535;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 01-MAY-2013, entry version 57.
DE RecName: Full=Probable acyl-CoA dehydrogenase FadE10;
DE EC=1.3.-.-;
GN Name=fadE10; OrderedLocusNames=Rv0873, MT0896;
GN ORFNames=MTCY31.01, MTV043.66;
OS Mycobacterium tuberculosis.
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1773;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M.,
RA Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III,
RA Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
RA Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S.,
RA Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A.,
RA Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R.,
RA Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the
RT complete genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/JB.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H.,
RA Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D.,
RA Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M.,
RA Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C.,
RA Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- CATALYTIC ACTIVITY: Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA +
CC reduced acceptor.
CC -!- COFACTOR: FAD (By similarity).
CC -!- SIMILARITY: Belongs to the acyl-CoA dehydrogenase family.
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DR EMBL; BX842574; CAA17679.1; -; Genomic_DNA.
DR EMBL; AE000516; AAK45138.1; -; Genomic_DNA.
DR EMBL; AL123456; CCP43621.1; -; Genomic_DNA.
DR PIR; A70817; A70817.
DR RefSeq; NP_215388.1; NC_000962.3.
DR RefSeq; NP_335324.1; NC_002755.2.
DR RefSeq; YP_006514224.1; NC_018143.1.
DR ProteinModelPortal; P63429; -.
DR SMR; P63429; 25-587.
DR STRING; 83332.Rv0873; -.
DR PRIDE; P63429; -.
DR EnsemblBacteria; AAK45138; AAK45138; MT0896.
DR GeneID; 13318775; -.
DR GeneID; 885636; -.
DR GeneID; 926206; -.
DR KEGG; mtc:MT0896; -.
DR KEGG; mtu:Rv0873; -.
DR KEGG; mtv:RVBD_0873; -.
DR PATRIC; 18123722; VBIMycTub22151_0985.
DR TubercuList; Rv0873; -.
DR eggNOG; COG1960; -.
DR HOGENOM; HOG000131667; -.
DR KO; K00257; -.
DR OMA; EGSTEIM; -.
DR ProtClustDB; CLSK871867; -.
DR GO; GO:0005618; C:cell wall; IDA:MTBBASE.
DR GO; GO:0005829; C:cytosol; IDA:MTBBASE.
DR GO; GO:0005886; C:plasma membrane; IDA:MTBBASE.
DR GO; GO:0003995; F:acyl-CoA dehydrogenase activity; IEA:InterPro.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR Gene3D; 1.10.540.10; -; 1.
DR Gene3D; 2.40.110.10; -; 1.
DR InterPro; IPR006092; Acyl-CoA_DH_N.
DR InterPro; IPR006090; Acyl-CoA_Oxase/DH_1.
DR InterPro; IPR006091; Acyl-CoA_Oxase/DH_cen-dom.
DR InterPro; IPR009075; AcylCo_DH/oxidase_C.
DR InterPro; IPR013786; AcylCoA_DH/ox_N.
DR InterPro; IPR009100; AcylCoA_DH/oxidase.
DR Pfam; PF00441; Acyl-CoA_dh_1; 1.
DR Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR Pfam; PF02771; Acyl-CoA_dh_N; 1.
DR SUPFAM; SSF56645; AcylCoA_dehyd_NM; 1.
DR SUPFAM; SSF47203; AcylCoADH_C_like; 1.
DR PROSITE; PS00072; ACYL_COA_DH_1; FALSE_NEG.
DR PROSITE; PS00073; ACYL_COA_DH_2; FALSE_NEG.
PE 3: Inferred from homology;
KW Complete proteome; FAD; Flavoprotein; Oxidoreductase;
KW Reference proteome.
FT CHAIN 1 650 Probable acyl-CoA dehydrogenase FadE10.
FT /FTId=PRO_0000201209.
FT COMPBIAS 443 464 Ala-rich.
FT ACT_SITE 422 422 Proton acceptor (By similarity).
SQ SEQUENCE 650 AA; 70745 MW; FECF934A3F01C0D1 CRC64;
MAQQTQVTEE QARALAEESR ESGWDKPSFA KELFLGRFPL GLIHPFPKPS DAEEARTEAF
LVKLREFLDT VDGSVIERAA QIPDEYVKGL AELGCFGLKI PSEYGGLNMS QVAYNRVLMM
VTTVHSSLGA LLSAHQSIGV PEPLKLAGTA EQKRRFLPRC AAGAISAFLL TEPDVGSDPA
RMASTATPID DGQAYELEGV KLWTTNGVVA DLLVVMARVP RSEGHRGGIS AFVVEADSPG
ITVERRNKFM GLRGIENGVT RLHRVRVPKD NLIGREGDGL KIALTTLNAG RLSLPAIATG
VAKQALKIAR EWSVERVQWG KPVGQHEAVA SKISFIAATN YALDAVVELS SQMADEGRND
IRIEAALAKL WSSEMACLVG DELLQIRGGR GYETAESLAA RGERAVPVEQ MVRDLRINRI
FEGSSEIMRL LIAREAVDAH LTAAGDLANP KADLRQKAAA AAGASGFYAK WLPKLVFGEG
QLPTTYREFG ALATHLRFVE RSSRKLARNT FYGMARWQAS LEKKQGFLGR IVDIGAELFA
ISAACVRAEA QRTADPVEGE QAYELAEAFC QQATLRVEAL FDALWSNTDS IDVRLANDVL
EGRYTWLEQG ILDQSEGTGP WIASWEPGPS TEANLARRFL TVSPSSEAKL
//
