ID COAE_STRP8 Reviewed; 197 AA.
AC P63834; Q8P249;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 01-MAY-2013, entry version 58.
DE RecName: Full=Dephospho-CoA kinase;
DE EC=2.7.1.24;
DE AltName: Full=Dephosphocoenzyme A kinase;
GN Name=coaE; OrderedLocusNames=spyM18_0556;
OS Streptococcus pyogenes serotype M18 (strain MGAS8232).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=186103;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGAS8232;
RX PubMed=11917108; DOI=10.1073/pnas.062526099;
RA Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S.,
RA Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F.,
RA Parkins L.D., Beres S.B., Campbell D.S., Smith T.M., Zhang Q.,
RA Kapur V., Daly J.A., Veasy L.G., Musser J.M.;
RT "Genome sequence and comparative microarray analysis of serotype M18
RT group A Streptococcus strains associated with acute rheumatic fever
RT outbreaks.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002).
CC -!- FUNCTION: Catalyzes the phosphorylation of the 3'-hydroxyl group
CC of dephosphocoenzyme A to form coenzyme A (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + 3'-dephospho-CoA = ADP + CoA.
CC -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from
CC (R)-pantothenate: step 5/5.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the CoaE family.
CC -!- SIMILARITY: Contains 1 DPCK (dephospho-CoA kinase) domain.
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DR EMBL; AE009949; AAL97252.1; -; Genomic_DNA.
DR RefSeq; NP_606753.1; NC_003485.1.
DR ProteinModelPortal; P63834; -.
DR STRING; 186103.spyM18_0556; -.
DR EnsemblBacteria; AAL97252; AAL97252; spyM18_0556.
DR GeneID; 994922; -.
DR KEGG; spm:spyM18_0556; -.
DR PATRIC; 19747767; VBIStrPyo4396_0476.
DR eggNOG; COG0237; -.
DR HOGENOM; HOG000020768; -.
DR KO; K00859; -.
DR OMA; QRLACQM; -.
DR ProtClustDB; PRK00081; -.
DR UniPathway; UPA00241; UER00356.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0004140; F:dephospho-CoA kinase activity; IEA:HAMAP.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00376; Dephospho_CoA_kinase; 1; -.
DR InterPro; IPR001977; Depp_CoAkinase.
DR Pfam; PF01121; CoaE; 1.
DR TIGRFAMs; TIGR00152; TIGR00152; 1.
DR PROSITE; PS51219; DPCK; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coenzyme A biosynthesis; Complete proteome; Cytoplasm;
KW Kinase; Nucleotide-binding; Transferase.
FT CHAIN 1 197 Dephospho-CoA kinase.
FT /FTId=PRO_0000173017.
FT DOMAIN 2 197 DPCK.
FT NP_BIND 7 14 ATP (Potential).
SQ SEQUENCE 197 AA; 22074 MW; FAF9D4ACF60E744C CRC64;
MIIGITGGIA SGKSTVVKVI RKAGYQVIDA DQVVHDLQEK GGRLYEALRE AFGNQILKAD
GELDRTKLSE MLFSNPDNMA TSSAIQNQII KEELAAKRDH LAQSQAIFFM DIPLLMELGY
QDWFDAIWLV YVDAQTQLQR LMARNRLDKG KARQRIASQL PIEEKKPYAS LVIDNNGDME
TLIKQVQSAL LSLANPR
//
