ID RSUA_SALTI Reviewed; 231 AA.
AC P65841; Q8XGP8;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 01-MAY-2013, entry version 54.
DE RecName: Full=Ribosomal small subunit pseudouridine synthase A;
DE EC=5.4.99.19;
DE AltName: Full=16S pseudouridylate 516 synthase;
DE AltName: Full=16S rRNA pseudouridine(516) synthase;
DE AltName: Full=rRNA pseudouridylate synthase A;
DE AltName: Full=rRNA-uridine isomerase A;
GN Name=rsuA; OrderedLocusNames=STY2459, t0632;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P.,
RA Cronin A., Davis P., Davies R.M., Dowd L., White N., Farrar J.,
RA Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K.,
RA Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C.,
RA Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K.,
RA Whitehead S., Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella
RT enterica serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/JB.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J.,
RA Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2
RT and CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-
CC 516 in 16S ribosomal RNA (By similarity).
CC -!- CATALYTIC ACTIVITY: 16S rRNA uridine(516) = 16S rRNA
CC pseudouridine(516).
CC -!- SUBUNIT: Monomer (By similarity).
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RsuA family.
CC -!- SIMILARITY: Contains 1 S4 RNA-binding domain.
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DR EMBL; AL627273; CAD02605.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO68333.1; -; Genomic_DNA.
DR RefSeq; NP_804484.1; NC_004631.1.
DR ProteinModelPortal; P65841; -.
DR SMR; P65841; 1-230.
DR STRING; 220341.STY2459; -.
DR PRIDE; P65841; -.
DR EnsemblBacteria; AAO68333; AAO68333; t0632.
DR EnsemblBacteria; CAD02605; CAD02605; CAD02605.
DR GeneID; 1069758; -.
DR KEGG; stt:t0632; -.
DR PATRIC; 18542875; VBISalEnt120419_2487.
DR eggNOG; COG1187; -.
DR HOGENOM; HOG000044954; -.
DR KO; K06183; -.
DR OMA; IGPRFIM; -.
DR ProtClustDB; PRK10839; -.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.10.290.10; -; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR InterPro; IPR000748; PsdUridine_synth_RsuA/RluB/E/F.
DR InterPro; IPR018496; PsdUridine_synth_RsuA/RluB_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluD.
DR InterPro; IPR002942; S4_RNA-bd.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM00363; S4; 1.
DR SUPFAM; SSF55120; PsdUridine_synth_cat_dom; 1.
DR TIGRFAMs; TIGR00093; TIGR00093; 1.
DR PROSITE; PS01149; PSI_RSU; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW Complete proteome; Isomerase; RNA-binding; rRNA processing.
FT CHAIN 1 231 Ribosomal small subunit pseudouridine
FT synthase A.
FT /FTId=PRO_0000099972.
FT DOMAIN 1 68 S4 RNA-binding.
FT ACT_SITE 102 102 Nucleophile (By similarity).
SQ SEQUENCE 231 AA; 25760 MW; 29EF9A7C5BD1DEF5 CRC64;
MRLDKFIAQQ LGVSRAIAGR EIRGNRVTVD GDIIKNAAFK LLPEHAVAYD GNPLAQQHGP
RYFMLNKPQG YVCSTDDPDH PTVLYFLDEP VAYKLHAAGR LDIDTTGLVL MTDDGQWSHR
ITSPRHHCEK TYLVTLESPV ADDTAAQFAK GVQLHNEKDL TKPATLEVIT PVQVRLTISE
GRYHQVKRMF AAVGNRVVEL HRERIGAITL DENLAPGEYR PLTEEEIASV G
//
