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Database: UniProt
Entry: P65841
LinkDB: P65841
Original site: P65841 
ID   RSUA_SALTI              Reviewed;         231 AA.
AC   P65841; Q8XGP8;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   01-OCT-2014, entry version 61.
DE   RecName: Full=Ribosomal small subunit pseudouridine synthase A;
DE            EC=5.4.99.19;
DE   AltName: Full=16S pseudouridylate 516 synthase;
DE   AltName: Full=16S rRNA pseudouridine(516) synthase;
DE   AltName: Full=rRNA pseudouridylate synthase A;
DE   AltName: Full=rRNA-uridine isomerase A;
GN   Name=rsuA; OrderedLocusNames=STY2459, t0632;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P.,
RA   Cronin A., Davis P., Davies R.M., Dowd L., White N., Farrar J.,
RA   Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K.,
RA   Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C.,
RA   Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K.,
RA   Whitehead S., Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella
RT   enterica serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/JB.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J.,
RA   Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2
RT   and CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-
CC       516 in 16S ribosomal RNA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY: 16S rRNA uridine(516) = 16S rRNA
CC       pseudouridine(516).
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RsuA family.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 S4 RNA-binding domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00182}.
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DR   EMBL; AL513382; CAD02605.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO68333.1; -; Genomic_DNA.
DR   RefSeq; NP_456780.1; NC_003198.1.
DR   RefSeq; NP_804484.1; NC_004631.1.
DR   ProteinModelPortal; P65841; -.
DR   SMR; P65841; 1-230.
DR   STRING; 220341.STY2459; -.
DR   PRIDE; P65841; -.
DR   EnsemblBacteria; AAO68333; AAO68333; t0632.
DR   EnsemblBacteria; CAD02605; CAD02605; CAD02605.
DR   GeneID; 1248787; -.
DR   KEGG; sty:STY2459; -.
DR   PATRIC; 18542875; VBISalEnt120419_2487.
DR   eggNOG; COG1187; -.
DR   HOGENOM; HOG000044954; -.
DR   KO; K06183; -.
DR   OMA; ITCDGIV; -.
DR   OrthoDB; EOG6130DV; -.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.290.10; -; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR   InterPro; IPR000748; PsdUridine_synth_RsuA/RluB/E/F.
DR   InterPro; IPR018496; PsdUridine_synth_RsuA/RluB_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluD.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   Pfam; PF01479; S4; 1.
DR   SMART; SM00363; S4; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00093; TIGR00093; 1.
DR   PROSITE; PS01149; PSI_RSU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase; RNA-binding; rRNA processing.
FT   CHAIN         1    231       Ribosomal small subunit pseudouridine
FT                                synthase A.
FT                                /FTId=PRO_0000099972.
FT   DOMAIN        1     68       S4 RNA-binding. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00182}.
FT   ACT_SITE    102    102       Nucleophile. {ECO:0000250}.
SQ   SEQUENCE   231 AA;  25760 MW;  29EF9A7C5BD1DEF5 CRC64;
     MRLDKFIAQQ LGVSRAIAGR EIRGNRVTVD GDIIKNAAFK LLPEHAVAYD GNPLAQQHGP
     RYFMLNKPQG YVCSTDDPDH PTVLYFLDEP VAYKLHAAGR LDIDTTGLVL MTDDGQWSHR
     ITSPRHHCEK TYLVTLESPV ADDTAAQFAK GVQLHNEKDL TKPATLEVIT PVQVRLTISE
     GRYHQVKRMF AAVGNRVVEL HRERIGAITL DENLAPGEYR PLTEEEIASV G
//
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