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Database: UniProt
Entry: P67798
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ID   COX2_DROPE              Reviewed;         229 AA.
AC   P67798; C9QNS7; P29864;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   16-APR-2014, entry version 53.
DE   RecName: Full=Cytochrome c oxidase subunit 2;
DE            EC=1.9.3.1;
DE   AltName: Full=Cytochrome c oxidase polypeptide II;
GN   Name=mt:CoII; Synonyms=CoII;
OS   Drosophila persimilis (Fruit fly).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7234;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8393127;
RA   Beckenbach A.T., Wei Y.W., Liu H.;
RT   "Relationships in the Drosophila obscura species group, inferred from
RT   mitochondrial cytochrome oxidase II sequences.";
RL   Mol. Biol. Evol. 10:619-634(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSH-3 / Tucson 14011-0111.49;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
RN   [3]
RP   IDENTIFICATION.
RC   STRAIN=MSH-3 / Tucson 14011-0111.49;
RX   PubMed=19533212; DOI=10.1007/s00239-009-9255-0;
RA   Montooth K.L., Abt D.N., Hofmann J.W., Rand D.M.;
RT   "Comparative genomics of Drosophila mtDNA: Novel features of
RT   conservation and change across functional domains and lineages.";
RL   J. Mol. Evol. 69:94-114(2009).
CC   -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC       chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC       3 form the functional core of the enzyme complex. Subunit 2
CC       transfers the electrons from cytochrome c via its binuclear copper
CC       A center to the bimetallic center of the catalytic subunit 1.
CC   -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
CC       ferricytochrome c + 2 H(2)O.
CC   -!- COFACTOR: Copper A.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.
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DR   EMBL; M95143; AAA02773.2; -; Genomic_DNA.
DR   EMBL; BK006337; DAA06210.1; -; Genomic_DNA.
DR   ProteinModelPortal; P67798; -.
DR   SMR; P67798; 1-226.
DR   FlyBase; FBgn0012641; Dper\mt:CoII.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0022900; P:electron transport chain; IEA:InterPro.
DR   Gene3D; 1.10.287.90; -; 1.
DR   Gene3D; 2.60.40.420; -; 1.
DR   InterPro; IPR001505; Copper_CuA.
DR   InterPro; IPR008972; Cupredoxin.
DR   InterPro; IPR014222; Cyt_c_oxidase_su2.
DR   InterPro; IPR002429; Cyt_c_oxidase_su2_C.
DR   InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom.
DR   Pfam; PF00116; COX2; 1.
DR   Pfam; PF02790; COX2_TM; 1.
DR   SUPFAM; SSF49503; SSF49503; 1.
DR   SUPFAM; SSF81464; SSF81464; 1.
DR   TIGRFAMs; TIGR02866; CoxB; 1.
DR   PROSITE; PS00078; COX2; 1.
DR   PROSITE; PS50857; COX2_CUA; 1.
DR   PROSITE; PS50999; COX2_TM; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Copper; Electron transport; Membrane;
KW   Metal-binding; Mitochondrion; Mitochondrion inner membrane;
KW   Oxidoreductase; Respiratory chain; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN         1    229       Cytochrome c oxidase subunit 2.
FT                                /FTId=PRO_0000183583.
FT   TOPO_DOM      1     26       Mitochondrial intermembrane (Potential).
FT   TRANSMEM     27     48       Helical; (Potential).
FT   TOPO_DOM     49     62       Mitochondrial matrix (Potential).
FT   TRANSMEM     63     82       Helical; (Potential).
FT   TOPO_DOM     83    229       Mitochondrial intermembrane (Potential).
FT   METAL       161    161       Copper A (Probable).
FT   METAL       196    196       Copper A (Probable).
FT   METAL       200    200       Copper A (Probable).
FT   METAL       204    204       Copper A (Probable).
SQ   SEQUENCE   229 AA;  26264 MW;  90B9E7C38E66B071 CRC64;
     MSTWANLGLQ DSASPLMEQL IFFHDHALLI LVMITVLVGY LMFMLFFNSY VNRFLLHGQL
     IEMIWTILPA IILLFIAMPS LRLLYLLDEI NEPSITLKSI GHQWYWSYEY SDFNNVEFDS
     YMIPTNELSN DGFRLLDVDN RIVLPMNSQI RILVTAADVI HSWTVPALGV KVDGTPGRLN
     QTNFFINRPG LFYGQCSEIC GANHSFMPIV IESVPVNYFI KWISNSVNS
//
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