ID COX2_DROPE Reviewed; 229 AA.
AC P67798; C9QNS7; P29864;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 01-MAY-2013, entry version 49.
DE RecName: Full=Cytochrome c oxidase subunit 2;
DE EC=1.9.3.1;
DE AltName: Full=Cytochrome c oxidase polypeptide II;
GN Name=mt:CoII; Synonyms=CoII;
OS Drosophila persimilis (Fruit fly).
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7234;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8393127;
RA Beckenbach A.T., Wei Y.W., Liu H.;
RT "Relationships in the Drosophila obscura species group, inferred from
RT mitochondrial cytochrome oxidase II sequences.";
RL Mol. Biol. Evol. 10:619-634(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSH-3 / Tucson 14011-0111.49;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
RN [3]
RP IDENTIFICATION.
RC STRAIN=MSH-3 / Tucson 14011-0111.49;
RX PubMed=19533212; DOI=10.1007/s00239-009-9255-0;
RA Montooth K.L., Abt D.N., Hofmann J.W., Rand D.M.;
RT "Comparative genomics of Drosophila mtDNA: Novel features of
RT conservation and change across functional domains and lineages.";
RL J. Mol. Evol. 69:94-114(2009).
CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC 3 form the functional core of the enzyme complex. Subunit 2
CC transfers the electrons from cytochrome c via its binuclear copper
CC A center to the bimetallic center of the catalytic subunit 1.
CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
CC ferricytochrome c + 2 H(2)O.
CC -!- COFACTOR: Copper A.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC membrane protein.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.
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DR EMBL; M95143; AAA02773.2; -; Genomic_DNA.
DR EMBL; BK006337; DAA06210.1; -; Genomic_DNA.
DR ProteinModelPortal; P67798; -.
DR SMR; P67798; 1-226.
DR FlyBase; FBgn0012641; Dper\mt:CoII.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:EC.
DR GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.90; -; 1.
DR Gene3D; 2.60.40.420; -; 1.
DR InterPro; IPR001505; Copper_CuA.
DR InterPro; IPR008972; Cupredoxin.
DR InterPro; IPR014222; Cyt_c_oxidase_su2.
DR InterPro; IPR002429; Cyt_c_oxidase_su2_C.
DR InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom.
DR Pfam; PF00116; COX2; 1.
DR Pfam; PF02790; COX2_TM; 1.
DR SUPFAM; SSF49503; Cupredoxin; 1.
DR SUPFAM; SSF81464; Cyt_c_oxidase_II-like_TM; 1.
DR TIGRFAMs; TIGR02866; CoxB; 1.
DR PROSITE; PS00078; COX2; 1.
DR PROSITE; PS50857; COX2_CUA; 1.
DR PROSITE; PS50999; COX2_TM; 1.
PE 3: Inferred from homology;
KW Complete proteome; Copper; Electron transport; Membrane;
KW Metal-binding; Mitochondrion; Mitochondrion inner membrane;
KW Oxidoreductase; Respiratory chain; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1 229 Cytochrome c oxidase subunit 2.
FT /FTId=PRO_0000183583.
FT TOPO_DOM 1 26 Mitochondrial intermembrane (Potential).
FT TRANSMEM 27 48 Helical; (Potential).
FT TOPO_DOM 49 62 Mitochondrial matrix (Potential).
FT TRANSMEM 63 82 Helical; (Potential).
FT TOPO_DOM 83 229 Mitochondrial intermembrane (Potential).
FT METAL 161 161 Copper A (Probable).
FT METAL 196 196 Copper A (Probable).
FT METAL 200 200 Copper A (Probable).
FT METAL 204 204 Copper A (Probable).
SQ SEQUENCE 229 AA; 26264 MW; 90B9E7C38E66B071 CRC64;
MSTWANLGLQ DSASPLMEQL IFFHDHALLI LVMITVLVGY LMFMLFFNSY VNRFLLHGQL
IEMIWTILPA IILLFIAMPS LRLLYLLDEI NEPSITLKSI GHQWYWSYEY SDFNNVEFDS
YMIPTNELSN DGFRLLDVDN RIVLPMNSQI RILVTAADVI HSWTVPALGV KVDGTPGRLN
QTNFFINRPG LFYGQCSEIC GANHSFMPIV IESVPVNYFI KWISNSVNS
//
