ID GLRX1_VACCP Reviewed; 108 AA.
AC P68691; P20818;
DT 07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-APR-2013, entry version 44.
DE RecName: Full=Glutaredoxin-1;
OS Vaccinia virus (strain L-IVP) (VACV).
OC Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae;
OC Orthopoxvirus; Vaccinia virus.
OX NCBI_TaxID=31531;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2250685;
RA Riazankina O.I., Shchelkunov S.N., Muravlev A.I., Netesova N.A.,
RA Mikriukov N.N., Gutorov V.V., Nikulin A.E., Kulichkov V.A.,
RA Malygin E.G.;
RT "Molecular-biological study of vaccinia virus genome. II. Localization
RT and nucleotide sequence of vaccinia virus genes coding for proteins
RT 36K and 12K.";
RL Mol. Biol. (Mosk.) 24:968-976(1990).
CC -!- FUNCTION: Has thioltransferase and dehydroascorbate reductase
CC activities.
CC -!- SUBCELLULAR LOCATION: Virion. Note=Localizes to the virion core
CC (By similarity).
CC -!- SIMILARITY: Belongs to the glutaredoxin family.
CC -!- SIMILARITY: Contains 1 glutaredoxin domain.
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DR EMBL; X61166; CAA43476.1; -; Genomic_DNA.
DR PIR; E42510; E42510.
DR RefSeq; YP_232951.1; NC_006998.1.
DR ProteinModelPortal; P68691; -.
DR SMR; P68691; 1-107.
DR GeneID; 3707602; -.
DR ProtClustDB; PHA3050; -.
DR GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell.
DR GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR GO; GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
DR GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR Gene3D; 3.40.30.10; -; 1.
DR InterPro; IPR011767; GLR_AS.
DR InterPro; IPR002109; Glutaredoxin.
DR InterPro; IPR011899; Glutaredoxin_euk/vir.
DR InterPro; IPR014025; Glutaredoxin_subgr.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR Pfam; PF00462; Glutaredoxin; 1.
DR PRINTS; PR00160; GLUTAREDOXIN.
DR SUPFAM; SSF52833; Thiordxn-like_fd; 1.
DR TIGRFAMs; TIGR02180; GRX_euk; 1.
DR PROSITE; PS00195; GLUTAREDOXIN_1; 1.
DR PROSITE; PS51354; GLUTAREDOXIN_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Electron transport; Redox-active center; Transport;
KW Virion.
FT CHAIN 1 108 Glutaredoxin-1.
FT /FTId=PRO_0000141616.
FT DOMAIN 3 106 Glutaredoxin.
FT DISULFID 23 26 Redox-active (By similarity).
SQ SEQUENCE 108 AA; 12355 MW; 8C754AE57D7F54D4 CRC64;
MAEEFVQQRL ANNKVTIFVK YTCPFCRNAL DILNKFSFKR GAYEIVDIKE FKPENELRDY
FEQITGGRTV PRIFFGKTSI GGYSDLLEID NMDALGDILS SIGVLRTC
//
