ID TANK_MOUSE Reviewed; 448 AA.
AC P70347; Q61178;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 29-MAY-2013, entry version 105.
DE RecName: Full=TRAF family member-associated NF-kappa-B activator;
DE AltName: Full=TRAF-interacting protein;
DE Short=I-TRAF;
GN Name=Tank; Synonyms=Itraf;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING.
RX PubMed=8710854; DOI=10.1073/pnas.93.16.8241;
RA Rothe M., Xiong J., Shu H.-B., Williamson K., Goddard A.,
RA Goeddel D.V.;
RT "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-
RT mediated signal transduction.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:8241-8246(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC STRAIN=C57BL/Kaplan; TISSUE=T-cell lymphoma;
RX PubMed=8608943;
RA Cheng G., Baltimore D.;
RT "TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB
RT activation.";
RL Genes Dev. 10:963-973(1996).
RN [3]
RP INTERACTION WITH IKBKG.
RX PubMed=12133833; DOI=10.1074/jbc.M205069200;
RA Chariot A., Leonardi A., Muller J., Bonif M., Brown K., Siebenlist U.;
RT "Association of the adaptor TANK with the I kappa B kinase (IKK)
RT regulator NEMO connects IKK complexes with IKK epsilon and TBK1
RT kinases.";
RL J. Biol. Chem. 277:37029-37036(2002).
CC -!- FUNCTION: Acts as a regulator of TRAF function by maintaining them
CC in a latent state. Overexpression inhibits TRAF2-mediated NF-
CC kappa-B activation signaled by CD40, TNFR1 and TNFR2. May be
CC involved in I-kappa-B-kinase (IKK) regulation; may function as an
CC adapter for kinases such as TBK1 or IKBKE that can modulate IKK
CC activity.
CC -!- SUBUNIT: Interacts with TBK1 (By similarity). Interacts also with
CC TRAF1, TRAF2, and TRAF3 by binding to their TRAF-C domains.
CC Interacts more strongly with TRAF1 and TRAF2 than TRAF3. Interacts
CC with IKBKG; the interaction is enhanced by IKBKE and TBK1. Part of
CC a ternary complex consisting of TANK, IKBKB and IKBKG (By
CC similarity).
CC -!- INTERACTION:
CC Q9WUN2:Tbk1; NbExp=4; IntAct=EBI-646116, EBI-764193;
CC P39428:Traf1; NbExp=12; IntAct=EBI-646125, EBI-520123;
CC P39429:Traf2; NbExp=7; IntAct=EBI-646125, EBI-520016;
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1; Synonyms=Beta;
CC IsoId=P70347-1; Sequence=Displayed;
CC Name=2; Synonyms=Alpha;
CC IsoId=P70347-2; Sequence=VSP_004444;
CC Name=3; Synonyms=Gamma;
CC IsoId=P70347-3; Sequence=VSP_004445, VSP_004446;
CC Name=4;
CC IsoId=P70347-4; Sequence=VSP_004447, VSP_004448;
CC -!- TISSUE SPECIFICITY: Heart, brain, spleen, lung, liver, skeletal
CC muscle, kidney and testis.
CC -!- SIMILARITY: Contains 1 C2H2-type zinc finger.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; U59864; AAC52781.1; -; mRNA.
DR EMBL; U51907; AAB02204.1; -; mRNA.
DR IPI; IPI00108187; -.
DR IPI; IPI00230207; -.
DR IPI; IPI00230208; -.
DR IPI; IPI00230209; -.
DR RefSeq; NP_001157544.1; NM_001164072.1.
DR RefSeq; NP_035659.1; NM_011529.2.
DR UniGene; Mm.244393; -.
DR ProteinModelPortal; P70347; -.
DR IntAct; P70347; 4.
DR PhosphoSite; P70347; -.
DR PRIDE; P70347; -.
DR Ensembl; ENSMUST00000078074; ENSMUSP00000077219; ENSMUSG00000064289.
DR Ensembl; ENSMUST00000112501; ENSMUSP00000108120; ENSMUSG00000064289.
DR GeneID; 21353; -.
DR KEGG; mmu:21353; -.
DR UCSC; uc008juw.2; mouse.
DR CTD; 10010; -.
DR MGI; MGI:107676; Tank.
DR eggNOG; NOG44252; -.
DR GeneTree; ENSGT00390000008712; -.
DR HOGENOM; HOG000231816; -.
DR HOVERGEN; HBG019299; -.
DR InParanoid; P70347; -.
DR KO; K12650; -.
DR OMA; ETQCSVP; -.
DR ChiTaRS; TANK; mouse.
DR NextBio; 300548; -.
DR ArrayExpress; P70347; -.
DR Bgee; P70347; -.
DR Genevestigator; P70347; -.
DR GermOnline; ENSMUSG00000064289; Mus musculus.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB cascade; IDA:MGI.
DR InterPro; IPR024581; TBD.
DR InterPro; IPR015880; Znf_C2H2-like.
DR Pfam; PF12845; TBD; 1.
DR SMART; SM00355; ZnF_C2H2; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; FALSE_NEG.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; FALSE_NEG.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Cytoplasm; Metal-binding;
KW Phosphoprotein; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1 448 TRAF family member-associated NF-kappa-B
FT activator.
FT /FTId=PRO_0000072428.
FT ZN_FING 417 443 C2H2-type.
FT REGION 205 224 TRAF family member interaction.
FT MOD_RES 377 377 Phosphoserine (By similarity).
FT MOD_RES 380 380 Phosphoserine (By similarity).
FT VAR_SEQ 1 34 Missing (in isoform 2).
FT /FTId=VSP_004444.
FT VAR_SEQ 238 251 GMSCVTAVTPRGLG -> ERRVCQLETTMCSM (in
FT isoform 3).
FT /FTId=VSP_004445.
FT VAR_SEQ 252 448 Missing (in isoform 3).
FT /FTId=VSP_004446.
FT VAR_SEQ 391 395 PFWKP -> VTVLH (in isoform 4).
FT /FTId=VSP_004447.
FT VAR_SEQ 396 448 Missing (in isoform 4).
FT /FTId=VSP_004448.
FT CONFLICT 68 68 Missing (in Ref. 2; AAB02204).
SQ SEQUENCE 448 AA; 50939 MW; 313E704C881FB5F3 CRC64;
MSLKRHSLRR NACHLETRAG IPTILYSDAT GQRGMDKNIG EQLNRAYEAF RQACMDRDSA
VRELQQKQTE NYEQRIREQQ EQLSFQQNLI DRLKSQLLLV DSSRDNSYGY VPLLEDSDRR
KNNLTLDEPH DKVKLGTLRD KQSKVRRQEV SSGKESAKGL NIPLHHERDN IEKTFWDLKE
EFHRICLLAK AQKDHLSKLN IPDIATDTQC SVPIQCTDKT EKQEALFKPQ AKDDINRGMS
CVTAVTPRGL GRDEEDTSFE SLSKFNVKFP PMDNDSIFLH STPEAPSILA PATPETVCQD
RFNMEVRDNP GNFVKTEETL FEIQGIDPIT SAIQNLKTTD KTNPSNLRAT CLPAGDHNVF
YVNTFPLQDP PDAPFPSLDS PGKAVRGPQQ PFWKPFLNQD TDLVVPSDSD SELLKPLVCE
FCQELFPPSI TSRGDFLRHL NTHFNGET
//
