ID CYSM_CAMJE Reviewed; 299 AA.
AC P71128; Q0P9Y7; Q9PP20;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 01-MAY-2013, entry version 94.
DE RecName: Full=Cysteine synthase B;
DE Short=CSase B;
DE EC=2.5.1.47;
DE AltName: Full=O-acetylserine (thiol)-lyase B;
DE Short=OAS-TL B;
DE AltName: Full=O-acetylserine sulfhydrylase B;
GN Name=cysM; OrderedLocusNames=Cj0912c;
OS Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Campylobacteraceae; Campylobacter.
OX NCBI_TaxID=192222;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=F38011;
RX PubMed=9034314; DOI=10.1016/S0378-1119(96)00631-2;
RA Garvis S.G., Tipton S.L., Konkel M.E.;
RT "Identification of a functional homolog of the Escherichia coli and
RT Salmonella typhimurium cysM gene encoding O-acetylserine sulfhydrylase
RT B in Campylobacter jejuni.";
RL Gene 185:63-67(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 11168;
RX PubMed=10688204; DOI=10.1038/35001088;
RA Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M.,
RA Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S.,
RA Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W.,
RA Quail M.A., Rajandream M.A., Rutherford K.M., van Vliet A.H.M.,
RA Whitehead S., Barrell B.G.;
RT "The genome sequence of the food-borne pathogen Campylobacter jejuni
RT reveals hypervariable sequences.";
RL Nature 403:665-668(2000).
CC -!- CATALYTIC ACTIVITY: O(3)-acetyl-L-serine + H(2)S = L-cysteine +
CC acetate.
CC -!- COFACTOR: Pyridoxal phosphate.
CC -!- PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis; L-
CC cysteine from L-serine: step 2/2.
CC -!- SIMILARITY: Belongs to the cysteine synthase/cystathionine beta-
CC synthase family.
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DR EMBL; U63157; AAC44853.1; -; Genomic_DNA.
DR EMBL; AL111168; CAL35032.1; -; Genomic_DNA.
DR PIR; G81364; G81364.
DR PIR; JC6185; JC6185.
DR RefSeq; YP_002344310.1; NC_002163.1.
DR ProteinModelPortal; P71128; -.
DR SMR; P71128; 4-295.
DR STRING; 192222.Cj0912c; -.
DR EnsemblBacteria; CAL35032; CAL35032; Cj0912c.
DR GeneID; 906009; -.
DR KEGG; cje:Cj0912c; -.
DR PATRIC; 20058768; VBICamJej33762_0896.
DR eggNOG; COG0031; -.
DR HOGENOM; HOG000217394; -.
DR KO; K01738; -.
DR OMA; GYRLIVT; -.
DR ProtClustDB; CLSK878988; -.
DR BioCyc; CJEJ192222:GJTS-880-MONOMER; -.
DR UniPathway; UPA00136; UER00200.
DR GO; GO:0004124; F:cysteine synthase activity; IEA:EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006535; P:cysteine biosynthetic process from serine; IEA:InterPro.
DR InterPro; IPR001216; Cys_synth_BS.
DR InterPro; IPR005856; Cys_synthKM.
DR InterPro; IPR005859; CysK.
DR InterPro; IPR000634; Ser/Thr_deHydtase_PyrdxlP-BS.
DR InterPro; IPR001926; Trp_syn_b_sub_like_PLP_eny_SF.
DR Pfam; PF00291; PALP; 1.
DR SUPFAM; SSF53686; PyrdxlP-dep_enz_bsu; 1.
DR TIGRFAMs; TIGR01139; cysK; 1.
DR TIGRFAMs; TIGR01136; cysKM; 1.
DR PROSITE; PS00901; CYS_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Complete proteome; Cysteine biosynthesis;
KW Pyridoxal phosphate; Reference proteome; Transferase.
FT CHAIN 1 299 Cysteine synthase B.
FT /FTId=PRO_0000167107.
FT REGION 174 178 Pyridoxal phosphate binding (By
FT similarity).
FT BINDING 70 70 Pyridoxal phosphate (By similarity).
FT BINDING 261 261 Pyridoxal phosphate (By similarity).
FT MOD_RES 40 40 N6-(pyridoxal phosphate)lysine (By
FT similarity).
FT CONFLICT 87 87 I -> V (in Ref. 1; AAC44853).
FT CONFLICT 99 99 R -> K (in Ref. 1; AAC44853).
FT CONFLICT 235 235 E -> Q (in Ref. 1; AAC44853).
FT CONFLICT 254 254 S -> I (in Ref. 1; AAC44853).
SQ SEQUENCE 299 AA; 32385 MW; 8298782DA1852ACB CRC64;
MKVHEKVSEL IGNTPIIHLK KFGINVFAKC EFLNPSHSIK DRAAFEMIKD ALDSKKINQD
TTIVEATSGN TGISLAMICA DLGLKFIAVM PESMSLERRK MITLFGARLE LTPANLGMKG
AVDKANEILL NTPNSFMVSQ FENISNKNAH RKNTALEILR DLDNELDIFV AGFGTGGTIS
GVGEILKEKL EKVHIVGVEP LNSPLLSKGE AGSHKIQGIG ANFIPAILNK EVIDEVITVS
NEDAINTAKE LAKSGLMVGI SSGANVFAAS MLAKKFPDKR ILTMLNDTAE RYLSTDLFA
//
