ID LEP1_SYNY3 Reviewed; 196 AA.
AC P72660;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 01-MAY-2013, entry version 98.
DE RecName: Full=Probable signal peptidase I-1;
DE Short=SPase I-1;
DE EC=3.4.21.89;
DE AltName: Full=Leader peptidase I-1;
GN Name=lepB1; OrderedLocusNames=sll0716;
OS Synechocystis sp. (strain PCC 6803 / Kazusa).
OC Bacteria; Cyanobacteria; Oscillatoriophycideae; Chroococcales;
OC Synechocystis.
OX NCBI_TaxID=1111708;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 6803 / Kazusa;
RX PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T.,
RA Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S.,
RA Shimpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M.,
RA Tabata S.;
RT "Sequence analysis of the genome of the unicellular cyanobacterium
RT Synechocystis sp. strain PCC6803. II. Sequence determination of the
RT entire genome and assignment of potential protein-coding regions.";
RL DNA Res. 3:109-136(1996).
CC -!- CATALYTIC ACTIVITY: Cleavage of hydrophobic, N-terminal signal or
CC leader sequences from secreted and periplasmic proteins.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane
CC protein (Potential).
CC -!- SIMILARITY: Belongs to the peptidase S26 family.
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DR EMBL; BA000022; BAA16662.1; -; Genomic_DNA.
DR PIR; S74510; S74510.
DR RefSeq; NP_439982.1; NC_000911.1.
DR RefSeq; YP_005650037.1; NC_017277.1.
DR RefSeq; YP_007449865.1; NC_020286.1.
DR ProteinModelPortal; P72660; -.
DR IntAct; P72660; 3.
DR STRING; 1148.sll0716; -.
DR MEROPS; S26.008; -.
DR EnsemblBacteria; BAA16662; BAA16662; BAA16662.
DR GeneID; 12253790; -.
DR GeneID; 14615506; -.
DR GeneID; 953147; -.
DR KEGG; syn:sll0716; -.
DR KEGG; syy:SYNGTS_0084; -.
DR PATRIC; 23837034; VBISynSp132158_0092.
DR eggNOG; COG0681; -.
DR HOGENOM; HOG000003673; -.
DR KO; K03100; -.
DR OMA; DYIAEPP; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.10.109.10; -; 2.
DR InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR InterPro; IPR019758; Pept_S26A_signal_pept_1_CS.
DR InterPro; IPR019757; Pept_S26A_signal_pept_1_Lys-AS.
DR InterPro; IPR019756; Pept_S26A_signal_pept_1_Ser-AS.
DR InterPro; IPR019759; Peptidase_S24_S26.
DR InterPro; IPR015927; Peptidase_S24_S26A/B/C.
DR InterPro; IPR011056; Peptidase_S24_S26A/B/C_b-rbn.
DR PANTHER; PTHR12383; PTHR12383; 1.
DR Pfam; PF00717; Peptidase_S24; 1.
DR PRINTS; PR00727; LEADERPTASE.
DR SUPFAM; SSF51306; Pept_S24_S26_C; 1.
DR TIGRFAMs; TIGR02227; sigpep_I_bact; 1.
DR PROSITE; PS00501; SPASE_I_1; 1.
DR PROSITE; PS00760; SPASE_I_2; 1.
DR PROSITE; PS00761; SPASE_I_3; 1.
PE 3: Inferred from homology;
KW Cell membrane; Complete proteome; Hydrolase; Membrane; Protease;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1 196 Probable signal peptidase I-1.
FT /FTId=PRO_0000109535.
FT TOPO_DOM 1 16 Cytoplasmic (Potential).
FT TRANSMEM 17 35 Helical; (Potential).
FT TOPO_DOM 36 196 Periplasmic (Potential).
FT ACT_SITE 44 44 By similarity.
FT ACT_SITE 94 94 By similarity.
SQ SEQUENCE 196 AA; 22230 MW; EB02533BF7341573 CRC64;
MQNSPIPSPW QFIKENIPLL MVALVLALLL RFFVAEPRYI PSDSMLPTLE QGDRLVVEKV
SYHFHPPQVG DIIVFHPPEL LQVQGYDLGQ AFIKRVIALP GQTVEVNNGI VYRDGQPLQE
EYILEPPQYN LPAVRVPDGQ VFVMGDNRNN SNDSHVWGFL PQQNIIGHAL FRFFPASRWG
QLGSFTFVPA RTIINT
//
