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Database: UniProt
Entry: P72660
LinkDB: P72660
Original site: P72660 
ID   LEP1_SYNY3              Reviewed;         196 AA.
AC   P72660;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   01-OCT-2014, entry version 106.
DE   RecName: Full=Probable signal peptidase I-1;
DE            Short=SPase I-1;
DE            EC=3.4.21.89;
DE   AltName: Full=Leader peptidase I-1;
GN   Name=lepB1; OrderedLocusNames=sll0716;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Oscillatoriophycideae; Chroococcales;
OC   Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T.,
RA   Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S.,
RA   Shimpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M.,
RA   Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the
RT   entire genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- CATALYTIC ACTIVITY: Cleavage of hydrophobic, N-terminal signal or
CC       leader sequences from secreted and periplasmic proteins.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass
CC       type II membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S26 family. {ECO:0000305}.
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DR   EMBL; BA000022; BAA16662.1; -; Genomic_DNA.
DR   PIR; S74510; S74510.
DR   RefSeq; NP_439982.1; NC_000911.1.
DR   RefSeq; YP_005650037.1; NC_017277.1.
DR   RefSeq; YP_007449865.1; NC_020286.1.
DR   ProteinModelPortal; P72660; -.
DR   IntAct; P72660; 3.
DR   STRING; 1148.sll0716; -.
DR   MEROPS; S26.008; -.
DR   EnsemblBacteria; BAA16662; BAA16662; BAA16662.
DR   GeneID; 953147; -.
DR   KEGG; syn:sll0716; -.
DR   KEGG; syy:SYNGTS_0084; -.
DR   KEGG; syz:MYO_1840; -.
DR   PATRIC; 23837034; VBISynSp132158_0092.
DR   eggNOG; COG0681; -.
DR   HOGENOM; HOG000003673; -.
DR   KO; K03100; -.
DR   OMA; IWRYWPL; -.
DR   OrthoDB; EOG63VC3Q; -.
DR   PhylomeDB; P72660; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   Gene3D; 2.10.109.10; -; 2.
DR   InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR   InterPro; IPR019758; Pept_S26A_signal_pept_1_CS.
DR   InterPro; IPR019757; Pept_S26A_signal_pept_1_Lys-AS.
DR   InterPro; IPR019756; Pept_S26A_signal_pept_1_Ser-AS.
DR   InterPro; IPR028360; Peptidase_S24/S26_b-rbn.
DR   InterPro; IPR019759; Peptidase_S24_S26.
DR   InterPro; IPR015927; Peptidase_S24_S26A/B/C.
DR   PANTHER; PTHR12383; PTHR12383; 1.
DR   Pfam; PF00717; Peptidase_S24; 1.
DR   PRINTS; PR00727; LEADERPTASE.
DR   SUPFAM; SSF51306; SSF51306; 1.
DR   TIGRFAMs; TIGR02227; sigpep_I_bact; 1.
DR   PROSITE; PS00501; SPASE_I_1; 1.
DR   PROSITE; PS00760; SPASE_I_2; 1.
DR   PROSITE; PS00761; SPASE_I_3; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Complete proteome; Hydrolase; Membrane; Protease;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN         1    196       Probable signal peptidase I-1.
FT                                /FTId=PRO_0000109535.
FT   TOPO_DOM      1     16       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     17     35       Helical. {ECO:0000255}.
FT   TOPO_DOM     36    196       Periplasmic. {ECO:0000255}.
FT   ACT_SITE     44     44       {ECO:0000250}.
FT   ACT_SITE     94     94       {ECO:0000250}.
SQ   SEQUENCE   196 AA;  22230 MW;  EB02533BF7341573 CRC64;
     MQNSPIPSPW QFIKENIPLL MVALVLALLL RFFVAEPRYI PSDSMLPTLE QGDRLVVEKV
     SYHFHPPQVG DIIVFHPPEL LQVQGYDLGQ AFIKRVIALP GQTVEVNNGI VYRDGQPLQE
     EYILEPPQYN LPAVRVPDGQ VFVMGDNRNN SNDSHVWGFL PQQNIIGHAL FRFFPASRWG
     QLGSFTFVPA RTIINT
//
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