ID P78409_HUMAN Unreviewed; 731 AA.
AC P78409;
DT 01-MAY-1997, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1998, sequence version 2.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=Butyrophilin {ECO:0000313|EMBL:AAC02656.1};
GN Name=BT3.3 {ECO:0000313|EMBL:AAC02656.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAC02656.1};
RN [1] {ECO:0000313|EMBL:AAC02656.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=9382921; DOI=10.1007/s002510050326;
RA Tazi-Ahnini R., Henry J., Offer C., Bouissou-Bouchouata C., Mather I.H.,
RA Pontarotti P.;
RT "Cloning, localization, and structure of new members of the butyrophilin
RT gene family in the juxta-telomeric region of the major histocompatibility
RT complex.";
RL Immunogenetics 47:55-63(1997).
RN [2] {ECO:0000313|EMBL:AAC02656.1}
RP NUCLEOTIDE SEQUENCE.
RA Tazi Ahnini R., Henry J., Offer C., Bouchouata C., Mather I.H.,
RA Pontarotti P.;
RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
CC {ECO:0000256|ARBA:ARBA00007591}.
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DR EMBL; AH005866; AAC02656.1; -; Genomic_DNA.
DR EMBL; U97501; AAC02656.1; JOINED; Genomic_DNA.
DR MaxQB; P78409; -.
DR PeptideAtlas; P78409; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR CDD; cd05713; IgV_MOG_like; 1.
DR CDD; cd15820; SPRY_PRY_BTN3; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR037954; SPRY_PRY_BTN3.
DR PANTHER; PTHR24100; BUTYROPHILIN; 1.
DR PANTHER; PTHR24100:SF115; BUTYROPHILIN SUBFAMILY 3 MEMBER A2; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF07686; V-set; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00022692}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..731
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004161346"
FT DOMAIN 24..140
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 162..234
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 480..674
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 673..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 731 AA; 81407 MW; 2F0E0A32B73685F0 CRC64;
MASSLAFLLL NFHVSLFLVQ LLTPCSAQFS VLGPSGPILA MVGEDADLPC HLFPTMSAET
MELRWVSSSL RQVVNVYADG KEVEYRQSAP YRGRTSILRD GITAGKAALR IHNVTASDSG
KYLCYFQHGD FYEKAPVELK VAALGSDLHI EVKGYDDGGI HLECRSTGWY PQPQINWSDS
KGENIPAVEG PVNVYGVGLY AVPPPVIMTG TSGGGVSCII TNSLLGLEKT ASISIADPFI
QGGAPARXXX GPGXGTLAYF XVAXSWQGAS YFLWRQQKEX IGLSRETERE REMKEMGYXA
TEQEISAKRS LQEELKWRKI QYMARGEESS SDTKKSALML KWKKALFKPG DKMLQMRVSP
CKINWMYSKI YCRKGELIKF ISGRVKIENK PLSIKHQWAX SMWGGKQQKC XKRILVASWG
RIRVLGKAXT DLTFISPLVT RPLGLSPMTL MRESHSGQAR DTGFWKDLLS MAQALHAVAL
KSRKNGRPHG HLLKLSAADV ILYPDMANAI LLVSEDQRSV QRAEEPHDLP DNPERFEWRY
CVLGCESFMS ERHYWEVEVG DRKEWHIGVC SKNVERKKVW VKMTPENGYW TMGLTDGNKY
RALTEPRTNL KLPEPPRKVG VILDYETGHI SFYNATDGSH IYTFLHASSS EPLYPVFRIL
TLEPTALTVC PIPKVESSPD PDLVPDHSLE IPLTPGLANE SGEPQAEVTS LLLPAQPGAK
GLTLHNSQSE P
//
