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Database: UniProt
Entry: P81764
LinkDB: P81764
Original site: P81764 
ID   ADHR_DROPS              Reviewed;         278 AA.
AC   P81764; B5DHK7; P26621; Q53WW1;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 2.
DT   01-OCT-2014, entry version 63.
DE   RecName: Full=Alcohol dehydrogenase-related 31 kDa protein;
GN   Name=Adhr; Synonyms=Adh-dup; ORFNames=GA25223;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3666441;
RA   Schaeffer S.W., Aquadro C.F.;
RT   "Nucleotide sequence of the Adh gene region of Drosophila
RT   pseudoobscura: evolutionary change and evidence for an ancient gene
RT   duplication.";
RL   Genetics 117:61-73(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PS271;
RX   PubMed=12688655; DOI=10.1017/S0016672302005955;
RA   Schaeffer S.W.;
RT   "Molecular population genetics of sequence length diversity in the Adh
RT   region of Drosophila pseudoobscura.";
RL   Genet. Res. 80:163-175(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P.,
RA   Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J.,
RA   van Batenburg M.F., Howells S.L., Scherer S.E., Sodergren E.,
RA   Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D.,
RA   Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D.,
RA   Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R.,
RA   Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L.,
RA   Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura:
RT   chromosomal, gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family. {ECO:0000305}.
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DR   EMBL; Y00602; CAA68646.1; -; Genomic_DNA.
DR   EMBL; U64535; AAL35977.1; -; Genomic_DNA.
DR   EMBL; CH379058; EDY69784.1; -; Genomic_DNA.
DR   PIR; S07246; S07246.
DR   RefSeq; XP_002132382.1; XM_002132346.1.
DR   EnsemblMetazoa; FBtr0280542; FBpp0278980; FBgn0012689.
DR   GeneID; 6903503; -.
DR   KEGG; dpo:Dpse_GA25223; -.
DR   FlyBase; FBgn0012689; Dpse\Adhr.
DR   eggNOG; COG1028; -.
DR   InParanoid; P81764; -.
DR   OrthoDB; EOG7966HT; -.
DR   GO; GO:0004022; F:alcohol dehydrogenase (NAD) activity; IEA:InterPro.
DR   Gene3D; 3.40.50.720; -; 1.
DR   InterPro; IPR002427; ADH-rel.
DR   InterPro; IPR002424; ADH_insect.
DR   InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR01170; ADHRELATED.
DR   PRINTS; PR01167; INSADHFAMILY.
DR   PRINTS; PR00080; SDRFAMILY.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Oxidoreductase; Reference proteome.
FT   CHAIN         1    278       Alcohol dehydrogenase-related 31 kDa
FT                                protein.
FT                                /FTId=PRO_0000054511.
FT   NP_BIND      11     34       NAD or NADP. {ECO:0000250}.
FT   ACT_SITE    152    152       Proton acceptor. {ECO:0000255|PROSITE-
FT                                ProRule:PRU10001}.
FT   BINDING     139    139       Substrate. {ECO:0000250}.
FT   CONFLICT    172    172       F -> Y (in Ref. 1; CAA68646 and 2;
FT                                AAL35977). {ECO:0000305}.
FT   CONFLICT    200    200       A -> E (in Ref. 1; CAA68646 and 2;
FT                                AAL35977). {ECO:0000305}.
SQ   SEQUENCE   278 AA;  30821 MW;  5E689483773250EF CRC64;
     MYDLTGKHVC YVADCGGIAL ETSKVLMTKN IAKLAILQSV ENPPAIAQLQ SIKHSTQIFF
     WTFDVTMARE EMKKYFDEVM VQMDYIDVLI NGATLCDERN IDATINTNLT GMMNTVATVL
     PYMDRKMGGS GGLIVNVTSV IGLDPSPVFC AYSASKFGVI GFTRSLADPL YFTQNGVAVM
     AVCCGPTKVF VDRELTAFLA YGQSFADRLR RAPCQSTAVC GQNIVNAIER SENGQIWIAD
     KGGLESVALH WYWHMADQFV NYMQSTDDED QEFFLGQR
//
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