ID ADHR_DROPS Reviewed; 278 AA.
AC P81764; B5DHK7; P26621; Q53WW1;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-APR-2013, entry version 60.
DE RecName: Full=Alcohol dehydrogenase-related 31 kDa protein;
GN Name=Adhr; Synonyms=Adh-dup; ORFNames=GA25223;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3666441;
RA Schaeffer S.W., Aquadro C.F.;
RT "Nucleotide sequence of the Adh gene region of Drosophila
RT pseudoobscura: evolutionary change and evidence for an ancient gene
RT duplication.";
RL Genetics 117:61-73(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=PS271;
RX PubMed=12688655; DOI=10.1017/S0016672302005955;
RA Schaeffer S.W.;
RT "Molecular population genetics of sequence length diversity in the Adh
RT region of Drosophila pseudoobscura.";
RL Genet. Res. 80:163-175(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P.,
RA Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J.,
RA van Batenburg M.F., Howells S.L., Scherer S.E., Sodergren E.,
RA Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D.,
RA Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D.,
RA Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R.,
RA Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L.,
RA Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura:
RT chromosomal, gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC (SDR) family.
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DR EMBL; Y00602; CAA68646.1; -; Genomic_DNA.
DR EMBL; U64535; AAL35977.1; -; Genomic_DNA.
DR EMBL; CH379058; EDY69784.1; -; Genomic_DNA.
DR PIR; S07246; S07246.
DR RefSeq; XP_002132382.1; XM_002132346.1.
DR EnsemblMetazoa; FBtr0280542; FBpp0278980; FBgn0012689.
DR GeneID; 6903503; -.
DR KEGG; dpo:Dpse_GA25223; -.
DR FlyBase; FBgn0012689; Dpse\Adhr.
DR eggNOG; COG1028; -.
DR InParanoid; P81764; -.
DR OrthoDB; EOG44F4RW; -.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD) activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR Gene3D; 3.40.50.720; -; 1.
DR InterPro; IPR002427; ADH-rel.
DR InterPro; IPR002424; ADH_insect.
DR InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR01170; ADHRELATED.
DR PRINTS; PR01167; INSADHFAMILY.
DR PRINTS; PR00080; SDRFAMILY.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Complete proteome; Oxidoreductase; Reference proteome.
FT CHAIN 1 278 Alcohol dehydrogenase-related 31 kDa
FT protein.
FT /FTId=PRO_0000054511.
FT NP_BIND 11 34 NAD or NADP (By similarity).
FT ACT_SITE 152 152 Proton acceptor (By similarity).
FT BINDING 139 139 Substrate (By similarity).
FT CONFLICT 172 172 F -> Y (in Ref. 1; CAA68646 and 2;
FT AAL35977).
FT CONFLICT 200 200 A -> E (in Ref. 1; CAA68646 and 2;
FT AAL35977).
SQ SEQUENCE 278 AA; 30821 MW; 5E689483773250EF CRC64;
MYDLTGKHVC YVADCGGIAL ETSKVLMTKN IAKLAILQSV ENPPAIAQLQ SIKHSTQIFF
WTFDVTMARE EMKKYFDEVM VQMDYIDVLI NGATLCDERN IDATINTNLT GMMNTVATVL
PYMDRKMGGS GGLIVNVTSV IGLDPSPVFC AYSASKFGVI GFTRSLADPL YFTQNGVAVM
AVCCGPTKVF VDRELTAFLA YGQSFADRLR RAPCQSTAVC GQNIVNAIER SENGQIWIAD
KGGLESVALH WYWHMADQFV NYMQSTDDED QEFFLGQR
//
