Database: UniProt
Entry: P84023
LinkDB: P84023
Original site: P84023 
ID   SMAD3_CHICK             Reviewed;         426 AA.
AC   P84023;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   11-NOV-2015, entry version 97.
DE   RecName: Full=Mothers against decapentaplegic homolog 3;
DE            Short=MAD homolog 3;
DE            Short=Mad3;
DE            Short=Mothers against DPP homolog 3;
DE   AltName: Full=SMAD family member 3;
DE            Short=SMAD 3;
DE            Short=Smad3;
GN   Name=SMAD3; Synonyms=MADH3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RC   TISSUE=Muscle;
RA   Liu Y., Zhao X., Zhang Y., Chen Y., Zhu D.;
RT   "Cloning and expression of chicken Smad3.";
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional modulator activated by TGF-beta
CC       (transforming growth factor) and activin type 1 receptor kinase.
CC       SMAD3 is a receptor-regulated SMAD (R-SMAD) (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SARA (SMAD anchor for receptor
CC       activation); form trimers with another SMAD3 and the co-SMAD
CC       SMAD4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Note=In the cytoplasm in the absence of ligand.
CC       Migration to the nucleus when complexed with SMAD4 (By
CC       similarity). {ECO:0000250}.
CC   -!- DOMAIN: The MH2 domain is sufficient to carry protein nuclear
CC       export. {ECO:0000250}.
CC   -!- PTM: Phosphorylated on serine by TGF-beta and activin type 1
CC       receptor kinases. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dwarfin/SMAD family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 MH1 (MAD homology 1) domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00438}.
CC   -!- SIMILARITY: Contains 1 MH2 (MAD homology 2) domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00439}.
DR   EMBL; AY391265; AAQ89726.1; -; mRNA.
DR   RefSeq; NP_989806.1; NM_204475.1.
DR   UniGene; Gga.28197; -.
DR   ProteinModelPortal; P84023; -.
DR   SMR; P84023; 7-132, 221-417.
DR   BioGrid; 675429; 2.
DR   STRING; 9031.ENSGALP00000012766; -.
DR   PaxDb; P84023; -.
DR   Ensembl; ENSGALT00000012780; ENSGALP00000012765; ENSGALG00000007870.
DR   GeneID; 395132; -.
DR   KEGG; gga:395132; -.
DR   CTD; 4088; -.
DR   eggNOG; KOG3701; Eukaryota.
DR   GeneTree; ENSGT00760000119091; -.
DR   HOGENOM; HOG000286018; -.
DR   HOVERGEN; HBG053353; -.
DR   InParanoid; P84023; -.
DR   KO; K04500; -.
DR   PhylomeDB; P84023; -.
DR   TreeFam; TF314923; -.
DR   Reactome; R-GGA-1181150; Signaling by NODAL.
DR   Reactome; R-GGA-1502540; Signaling by Activin.
DR   Reactome; R-GGA-2173788; Downregulation of TGF-beta receptor signaling.
DR   Reactome; R-GGA-2173789; TGF-beta receptor signaling activates SMADs.
DR   Reactome; R-GGA-2173795; Downregulation of SMAD2/3:SMAD4 transcriptional activity.
DR   NextBio; 20815224; -.
DR   PRO; PR:P84023; -.
DR   Proteomes; UP000000539; Chromosome 10.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0000790; C:nuclear chromatin; IEA:Ensembl.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR   GO; GO:0071141; C:SMAD protein complex; ISS:UniProtKB.
DR   GO; GO:0071144; C:SMAD2-SMAD3 protein complex; IEA:Ensembl.
DR   GO; GO:0005667; C:transcription factor complex; ISS:UniProtKB.
DR   GO; GO:0031490; F:chromatin DNA binding; IEA:Ensembl.
DR   GO; GO:0000987; F:core promoter proximal region sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0000988; F:transcription factor activity, protein binding; IEA:Ensembl.
DR   GO; GO:0000983; F:transcription factor activity, RNA polymerase II core promoter sequence-specific; IEA:Ensembl.
DR   GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0030618; F:transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; IEA:Ensembl.
DR   GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR   GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
DR   GO; GO:0007050; P:cell cycle arrest; IEA:Ensembl.
DR   GO; GO:0045216; P:cell-cell junction organization; IEA:Ensembl.
DR   GO; GO:0048589; P:developmental growth; IEA:Ensembl.
DR   GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl.
DR   GO; GO:0048617; P:embryonic foregut morphogenesis; IEA:Ensembl.
DR   GO; GO:0009880; P:embryonic pattern specification; IEA:Ensembl.
DR   GO; GO:0007492; P:endoderm development; IEA:Ensembl.
DR   GO; GO:0019049; P:evasion or tolerance of host defenses by virus; IEA:Ensembl.
DR   GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR   GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:Ensembl.
DR   GO; GO:0002520; P:immune system development; IEA:Ensembl.
DR   GO; GO:0070306; P:lens fiber cell differentiation; IEA:Ensembl.
DR   GO; GO:0001889; P:liver development; IEA:Ensembl.
DR   GO; GO:0001707; P:mesoderm formation; IEA:Ensembl.
DR   GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:0045930; P:negative regulation of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
DR   GO; GO:0033689; P:negative regulation of osteoblast proliferation; IEA:Ensembl.
DR   GO; GO:0042177; P:negative regulation of protein catabolic process; IEA:Ensembl.
DR   GO; GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0061045; P:negative regulation of wound healing; IEA:Ensembl.
DR   GO; GO:0038092; P:nodal signaling pathway; IEA:Ensembl.
DR   GO; GO:0002076; P:osteoblast development; IEA:Ensembl.
DR   GO; GO:0048340; P:paraxial mesoderm morphogenesis; IEA:Ensembl.
DR   GO; GO:0060039; P:pericardium development; IEA:Ensembl.
DR   GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0035413; P:positive regulation of catenin import into nucleus; IEA:Ensembl.
DR   GO; GO:0032332; P:positive regulation of chondrocyte differentiation; IEA:Ensembl.
DR   GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Ensembl.
DR   GO; GO:1901203; P:positive regulation of extracellular matrix assembly; IEA:Ensembl.
DR   GO; GO:0042993; P:positive regulation of transcription factor import into nucleus; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR   GO; GO:0051098; P:regulation of binding; IEA:Ensembl.
DR   GO; GO:0050678; P:regulation of epithelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0050776; P:regulation of immune response; IEA:Ensembl.
DR   GO; GO:0016202; P:regulation of striated muscle tissue development; IEA:Ensembl.
DR   GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0032909; P:regulation of transforming growth factor beta2 production; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0007183; P:SMAD protein complex assembly; IEA:Ensembl.
DR   GO; GO:0060395; P:SMAD protein signal transduction; IEA:Ensembl.
DR   GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
DR   GO; GO:0042110; P:T cell activation; IEA:Ensembl.
DR   GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006810; P:transport; IEA:Ensembl.
DR   GO; GO:0001657; P:ureteric bud development; IEA:Ensembl.
DR   Gene3D;; -; 1.
DR   Gene3D; 3.90.520.10; -; 1.
DR   InterPro; IPR013790; Dwarfin.
DR   InterPro; IPR003619; MAD_homology1_Dwarfin-type.
DR   InterPro; IPR013019; MAD_homology_MH1.
DR   InterPro; IPR017855; SMAD_dom-like.
DR   InterPro; IPR001132; SMAD_dom_Dwarfin-type.
DR   InterPro; IPR008984; SMAD_FHA_domain.
DR   PANTHER; PTHR13703; PTHR13703; 1.
DR   Pfam; PF03165; MH1; 1.
DR   Pfam; PF03166; MH2; 1.
DR   SMART; SM00523; DWA; 1.
DR   SMART; SM00524; DWB; 1.
DR   SUPFAM; SSF49879; SSF49879; 1.
DR   SUPFAM; SSF56366; SSF56366; 1.
DR   PROSITE; PS51075; MH1; 1.
DR   PROSITE; PS51076; MH2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
KW   Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN         1    426       Mothers against decapentaplegic homolog
FT                                3.
FT                                /FTId=PRO_0000090860.
FT   DOMAIN       10    136       MH1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00438}.
FT   DOMAIN      233    426       MH2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00439}.
FT   METAL        64     64       Zinc. {ECO:0000250}.
FT   METAL       109    109       Zinc. {ECO:0000250}.
FT   METAL       121    121       Zinc. {ECO:0000250}.
FT   METAL       126    126       Zinc. {ECO:0000250}.
FT   MOD_RES     424    424       Phosphoserine. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00439}.
FT   MOD_RES     426    426       Phosphoserine. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00439}.
SQ   SEQUENCE   426 AA;  48252 MW;  58DC1F9A664EAC7C CRC64;
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