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Database: UniProt
Entry: P92953
LinkDB: P92953
Original site: P92953 
ID   ATHB4_ARATH             Reviewed;         318 AA.
AC   P92953; Q546G8;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   24-JAN-2024, entry version 165.
DE   RecName: Full=Homeobox-leucine zipper protein ATHB-4;
DE   AltName: Full=HD-ZIP protein ATHB-4;
DE   AltName: Full=Homeodomain transcription factor ATHB-4;
GN   Name=ATHB-4; OrderedLocusNames=At2g44910; ORFNames=T13E15.8;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RA   Steindler C., Morelli G., Ruberti I.;
RT   "Nucleotide sequence of the Arabidopsis ATHB-4 gene encoding an HD-Zip
RT   protein related to ATHB-2.";
RL   (er) Plant Gene Register PGR97-021(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Columbia;
RA   Steindler C., Carabelli M., Ciarbelli A.R., Ruzza V., Sessa G., Ruberti I.;
RT   "Nucleotide sequence of the Arabidopsis ATHB-4 mRNA, encoding an HD-Zip II
RT   protein related to ATHB-2.";
RL   Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [5]
RP   INDUCTION.
RX   PubMed=8106086; DOI=10.1046/j.1365-313x.1993.04030469.x;
RA   Carabelli M., Sessa G., Baima S., Morelli G., Ruberti I.;
RT   "The Arabidopsis Athb-2 and -4 genes are strongly induced by far-red-rich
RT   light.";
RL   Plant J. 4:469-479(1993).
RN   [6]
RP   GENE FAMILY.
RX   PubMed=16055682; DOI=10.1104/pp.105.063461;
RA   Henriksson E., Olsson A.S.B., Johannesson H., Johansson H., Hanson J.,
RA   Engstroem P., Soederman E.;
RT   "Homeodomain leucine zipper class I genes in Arabidopsis. Expression
RT   patterns and phylogenetic relationships.";
RL   Plant Physiol. 139:509-518(2005).
CC   -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC   -!- INTERACTION:
CC       P92953; O04292: ATHB-9; NbExp=4; IntAct=EBI-15192259, EBI-1536772;
CC       P92953; Q8GXM7: ATHB-X; NbExp=5; IntAct=EBI-15192259, EBI-3133795;
CC       P92953; P46600: HAT1; NbExp=4; IntAct=EBI-15192259, EBI-15195911;
CC       P92953; Q9LXU1: NOT9B; NbExp=3; IntAct=EBI-15192259, EBI-15193025;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- INDUCTION: By transition from light to far-red light.
CC       {ECO:0000269|PubMed:8106086}.
CC   -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class II subfamily.
CC       {ECO:0000305}.
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DR   EMBL; Y09582; CAA70771.1; -; Genomic_DNA.
DR   EMBL; AJ441251; CAD29650.1; -; mRNA.
DR   EMBL; AC002388; AAC31833.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC10483.1; -; Genomic_DNA.
DR   PIR; T00402; T00402.
DR   RefSeq; NP_182018.1; NM_130055.2.
DR   AlphaFoldDB; P92953; -.
DR   SMR; P92953; -.
DR   BioGRID; 4436; 13.
DR   IntAct; P92953; 13.
DR   STRING; 3702.P92953; -.
DR   PaxDb; 3702-AT2G44910-1; -.
DR   EnsemblPlants; AT2G44910.1; AT2G44910.1; AT2G44910.
DR   GeneID; 819100; -.
DR   Gramene; AT2G44910.1; AT2G44910.1; AT2G44910.
DR   KEGG; ath:AT2G44910; -.
DR   Araport; AT2G44910; -.
DR   TAIR; AT2G44910; HB4.
DR   eggNOG; KOG0483; Eukaryota.
DR   HOGENOM; CLU_049516_2_1_1; -.
DR   InParanoid; P92953; -.
DR   OMA; WTHLFQS; -.
DR   OrthoDB; 461623at2759; -.
DR   PhylomeDB; P92953; -.
DR   PRO; PR:P92953; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; P92953; baseline and differential.
DR   Genevisible; P92953; AT.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IMP:TAIR.
DR   GO; GO:0010218; P:response to far red light; IEP:TAIR.
DR   GO; GO:0009725; P:response to hormone; IMP:TAIR.
DR   GO; GO:0009641; P:shade avoidance; IEP:TAIR.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR006712; HD-ZIP_N.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR003106; Leu_zip_homeo.
DR   PANTHER; PTHR45714:SF11; HOMEOBOX-LEUCINE ZIPPER PROTEIN ATHB-4; 1.
DR   PANTHER; PTHR45714; HOMEOBOX-LEUCINE ZIPPER PROTEIN HAT14; 1.
DR   Pfam; PF02183; HALZ; 1.
DR   Pfam; PF04618; HD-ZIP_N; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00340; HALZ; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..318
FT                   /note="Homeobox-leucine zipper protein ATHB-4"
FT                   /id="PRO_0000048822"
FT   DNA_BIND        160..219
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          128..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          227..248
FT                   /note="Leucine-zipper"
SQ   SEQUENCE   318 AA;  34816 MW;  2D9B1CADFCF43D41 CRC64;
     MGERDDGLGL SLSLGNSQQK EPSLRLNLMP LTTSSSSSSF QHMHNQNNNS HPQKIHNISW
     THLFQSSGIK RTTAERNSDA GSFLRGFNVN RAQSSVAVVD LEEEAAVVSS PNSAVSSLSG
     NKRDLAVARG GDENEAERAS CSRGGGSGGS DDEDGGNGDG SRKKLRLSKD QALVLEETFK
     EHSTLNPKQK LALAKQLNLR ARQVEVWFQN RRARTKLKQT EVDCEYLKRC CDNLTEENRR
     LQKEVSELRA LKLSPHLYMH MTPPTTLTMC PSCERVSSSA ATVTAAPSTT TTPTVVGRPS
     PQRLTPWTAI SLQQKSGR
//
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