ID P95028_MYCTO Unreviewed; 240 AA.
AC P95028; F2GH33; Q7D6Z2;
DT 01-MAY-1997, integrated into UniProtKB/TrEMBL.
DT 01-MAY-1997, sequence version 1.
DT 24-JAN-2024, entry version 128.
DE RecName: Full=Rv2525c-like glycoside hydrolase-like domain-containing protein {ECO:0000259|Pfam:PF08924};
GN OrderedLocusNames=MT2601 {ECO:0000313|EMBL:AAK46909.1};
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331 {ECO:0000313|EMBL:AAK46909.1, ECO:0000313|Proteomes:UP000001020};
RN [1] {ECO:0000313|EMBL:AAK46909.1, ECO:0000313|Proteomes:UP000001020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh {ECO:0000313|Proteomes:UP000001020};
RX PubMed=12218036; DOI=10.1128/JB.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J., DeBoy R., Dodson R., Gwinn M., Haft D., Hickey E.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M., Salzberg S.L.,
RA Delcher A., Utterback T., Weidman J., Khouri H., Gill J., Mikula A.,
RA Bishai W., Jacobs Jr W.R.Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
RN [2] {ECO:0007829|PDB:4PMN, ECO:0007829|PDB:4PMO}
RP X-RAY CRYSTALLOGRAPHY (1.33 ANGSTROMS) OF 36-240.
RX PubMed=25260828; DOI=10.1016/j.jsb.2014.09.003;
RA Bellinzoni M., Haouz A., Miras I., Magnet S., Andre-Leroux G.,
RA Mukherjee R., Shepard W., Cole S.T., Alzari P.M.;
RT "Structural studies suggest a peptidoglycan hydrolase function for the
RT Mycobacterium tuberculosis Tat-secreted protein Rv2525c.";
RL J. Struct. Biol. 188:156-164(2014).
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DR EMBL; AE000516; AAK46909.1; -; Genomic_DNA.
DR PIR; A70657; A70657.
DR RefSeq; WP_003412957.1; NZ_KK341227.1.
DR PDB; 4PMN; X-ray; 1.44 A; A/B=36-240.
DR PDB; 4PMO; X-ray; 1.33 A; A/B=36-240.
DR PDB; 4PMQ; X-ray; 1.61 A; A=36-240.
DR PDB; 4PMR; X-ray; 1.81 A; A=36-240.
DR PDBsum; 4PMN; -.
DR PDBsum; 4PMO; -.
DR PDBsum; 4PMQ; -.
DR PDBsum; 4PMR; -.
DR AlphaFoldDB; P95028; -.
DR SMR; P95028; -.
DR GeneID; 45426525; -.
DR KEGG; mtc:MT2601; -.
DR PATRIC; fig|83331.31.peg.2804; -.
DR HOGENOM; CLU_075024_1_0_11; -.
DR Proteomes; UP000001020; Chromosome.
DR GO; GO:0005576; C:extracellular region; IDA:MTBBASE.
DR GO; GO:0046677; P:response to antibiotic; IEP:MTBBASE.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR015020; Rv2525c-like_Glyco_Hydro-like.
DR InterPro; IPR006311; TAT_signal.
DR InterPro; IPR019546; TAT_signal_bac_arc.
DR NCBIfam; TIGR01409; TAT_signal_seq; 1.
DR Pfam; PF08924; Rv2525c_GlyHyd-like; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR PROSITE; PS51318; TAT; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:4PMN, ECO:0007829|PDB:4PMO};
KW Reference proteome {ECO:0000313|Proteomes:UP000001020}.
FT DOMAIN 53..230
FT /note="Rv2525c-like glycoside hydrolase-like"
FT /evidence="ECO:0000259|Pfam:PF08924"
SQ SEQUENCE 240 AA; 25370 MW; AFB4F3331FFCC7F5 CRC64;
MSVSRRDVLK FAAATPGVLG LGVVASSLRA APASAGSLGT LLDYAAGVIP ASQIRAAGAV
GAIRYVSDRR PGGAWMLGKP IQLSEARDLS GNGLKIVSCY QYGKGSTADW LGGASAGVQH
ARRGSELHAA AGGPTSAPIY ASIDDNPSYE QYKNQIVPYL RSWESVIGHQ RTGVYANSKT
IDWAVNDGLG SYFWQHNWGS PKGYTHPAAH LHQVEIDKRK VGGVGVDVNQ ILKPQFGQWA
//
