ID P95814_STRSQ Unreviewed; 6420 AA.
AC P95814;
DT 01-MAY-1997, integrated into UniProtKB/TrEMBL.
DT 01-JUL-1997, sequence version 2.
DT 24-JAN-2024, entry version 135.
DE SubName: Full=FK506 polyketide synthase {ECO:0000313|EMBL:CAA71463.1};
GN Name=fkbA {ECO:0000313|EMBL:CAA71463.1};
OS Streptomyces sp.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1931 {ECO:0000313|EMBL:CAA71463.1};
RN [1] {ECO:0000313|EMBL:CAA71463.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MA6548 {ECO:0000313|EMBL:CAA71463.1};
RX PubMed=9063448; DOI=10.1111/j.1432-1033.1997.00074.x;
RA Motamedi H., Cai S.J., Shafiee A., Elliston K.O.;
RT "Structural organization of a multifunctional polyketide synthase involved
RT in the biosynthesis of the macrolide immunosuppressant FK506.";
RL Eur. J. Biochem. 244:74-80(1997).
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DR EMBL; Y10438; CAA71463.1; -; Genomic_DNA.
DR KEGG; ag:CAA71463; -.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR CDD; cd05195; enoyl_red; 2.
DR CDD; cd08956; KR_3_FAS_SDR_x; 2.
DR CDD; cd00833; PKS; 4.
DR Gene3D; 1.10.287.1960; -; 2.
DR Gene3D; 3.30.70.3290; -; 4.
DR Gene3D; 3.40.47.10; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 4.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 5.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 3.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; INACTIVE PHENOLPHTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PKS1-RELATED; 1.
DR Pfam; PF00698; Acyl_transf_1; 4.
DR Pfam; PF08240; ADH_N; 2.
DR Pfam; PF13602; ADH_zinc_N_2; 2.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 3.
DR Pfam; PF00109; ketoacyl-synt; 4.
DR Pfam; PF02801; Ketoacyl-synt_C; 4.
DR Pfam; PF08659; KR; 3.
DR Pfam; PF21089; PKS_DH_N; 2.
DR Pfam; PF00550; PP-binding; 4.
DR Pfam; PF14765; PS-DH; 2.
DR SMART; SM00827; PKS_AT; 4.
DR SMART; SM00826; PKS_DH; 3.
DR SMART; SM00829; PKS_ER; 2.
DR SMART; SM00822; PKS_KR; 3.
DR SMART; SM00825; PKS_KS; 4.
DR SMART; SM00823; PKS_PP; 4.
DR SMART; SM01294; PKS_PP_betabranch; 3.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 4.
DR SUPFAM; SSF50129; GroES-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 8.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 4.
DR SUPFAM; SSF53901; Thiolase-like; 4.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00606; KS3_1; 4.
DR PROSITE; PS52004; KS3_2; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 29..435
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1814..1889
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1908..2327
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3391..3466
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3483..3902
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 5307..5382
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5409..5829
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 6293..6368
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1801..1822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3009..3030
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4434..4458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5797..5836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5896..5929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1804..1822
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4436..4458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5817..5833
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6420 AA; 672230 MW; 25BCD2069456BEF1 CRC64;
MPEQDKTVEY LRWATTELQR TRAELAAHSE PLAIVGMACR LPGGVASPDD LWRLLESGGD
GIGAFPADRG WETGADGRGG FLTGAAGFDA GFFGVSPREA LAMDPQQRVV LETSWEALEH
AGIDPRSLNG SDTGVFLGAF FQGYGIGADF DGYGTTSIHT SVLSGRLSYF YGLEGPAVTV
DTACSSSLVA LHQAGQSLRT GECSLALVGG VTVMASPAGF ADFSEQGGLA SDGRCKAFAE
AADGTAFAEG SGVLVVERLS DAERHGHRVL AVVRGSAVNQ DGASNGLSAP NGPSQERVIR
QALAHAGLQP SDVDAVEAHG TGTRLGDPIE ATALLATYGQ DRATPLLLGS LKSNIGHTQA
AAGVAGIIKM VLAMRHGTLP PTLHVDTPSS HVDWTTGDVE LLTQARPWPQ TNRPHRAGIS
SFGVSGTNAH VIIESHPRPT PAPDTGSSTH PVPLLISART PEALDEHTTR IRAFLDDNPG
ADRVTVAQTL ARRTPFEHRA VLLGDTLITA DPNAGSGPVV FVYSGQSTLH PHTGHQLAAT
YSVFADAWGE VLGHLNADQG PATHFAHQIA LTALLRSWGI TPHAVIGHSL GEISAACAAG
VLSIGDASAL LAARSRLMDE LPTGGAMVTV LTSEENALRA LRPGVEIAAV NGPHSVVLSG
DEGPVLDVAQ QLGIHHRLPT RHAGHSARMD PLVAPLLEAA SGLTYHQPHT AIPEDPTTAA
YWARQVRDQV RFQAHAERYP GATFLEIGPN QDLSPVVDGI PTQTGTPEEV QALHTALARL
HTRGGVVDWP TVLGSDRAPV ALPTYPFQHK DYWLRATAQV DVTGAGQEKV AHPLLGAAVA
LPGTGGTVLT GRVSLASHPW LGGHAVNGTV LLPGAAFLEL AVRAGDETGS DLLHELVVET
PLTLPATGSV AISVEVAEPD DTGRRAVTVH ARADGAALWT RHATGFLGKA AATTAETGDP
APWPPAGARQ VDVGDVYERF AGIGYAYGSS FQGLLAAWRD GDTVHAEVAL PDEQVPDAAR
FTLHPALLDA AFQAGALSAL DAPGEAARLP FSFQDVRIHA AGATRARVTV SRDGDRSTVR
MTGEDGQPVA EVGSVVSRPY AGGSGSDDEL LRPVWTELPM PAPSAADPRV EVLDADPLDG
EPAAATRELT ARVLDSLQHR LSATDDVTLV VRIGTGLAAA ATAGLVRSAQ AENPGRFVLV
EAPPDTPADL LTACAALDEP QLAVRDGVLF APRLVRMSDP VHGPLPLPDG DWLLAHSASG
VLQDVTLAAD GTPRRALEAG EVRVDVRAAG LNFRDVLIAL GTYDGATALG GEAAGVVVET
GPGVADLAPG DRVFGLTRGG IGPTAVTDRR WLARIPDGWT FATAASVPIA FATAWYGLVD
LAGLRAGEKV LVHAATGGVA MAATQVARHL GAEVYATAGT GKQHVLRAAG LPGTHVADSR
TTAFRTDFPR MDVVLNSLTG EFIDASLELL DADGRFVEMG RAELRDPATI APAYLPFDLL
DAGTDRIGEI LGELLRLFDA GALTPLPVRA WDIRQARDAL GVMSRARHIG KNVLTLPRPL
DPEGAIVITG GSGTLAGILA RHVSAQHVYL LSRSAPPEGT PGIHLPCDVS DRQQLAAALR
RIDRPITAVV HTAGALDDGT LPSLTPGRFD TELRPKADGA WHLHELTKDQ DLAAFVLYSS
AAGVLGNAGQ GNYAAANAFL DALAEQRRAA GLPALSIAWG LWEDASGLTA ELSEADRQRM
RRSGFRTITA RQGMRLYEAA RRTGSPVVVA AALDDAPDVP LLRGLRRTTV RRAAVRERSL
ADRSPCCPTT SAPTPPSRSS WNSTATVLGH LGAEDIPATT TFKELGIDSL TAVQLRNALT
TATGVRLNAT AVFDFPTPRA LAARLGDELA GTRAPVAART AATAAAHDEP LAIVGMACRL
PGGVASPQEL WRLVASGTDA ITEFPADRGW DVDALYDPDP DAIGKTFVRH GGFLDGATGF
DAAFFGISPR EALAMDPQQR VLLETSWEAF ESAGITPDAA RGSDTGVFIG AFSYGYGTGA
DTNGFGATGS QTSVLSGRLS YFYGLEGPSV TVDTACSSSL VALHQAGQSL RSGECSLALV
GGVTVMASPG GFVEFSRQRG LAPDGRAKAF GAGADGTSFA EGAGALVVER LSDAERHGHT
VLALVRGSAA NSDGASNGLS APNGPSQERV IHQALANAKL TPADVDAVEA HGTGTRLGDP
IEAQALLATY GQDRATPLLL GSLKSNIGHA QAASGVAGII KMVQAIRHGE LPPTLHADEP
SPHVDWTAGA VELLTSARPW PGTGRPRRAA VSSFGVSGTN AHIILEAGPV KTGPVEAGAI
EAGPVEVGPV EAGPLPAAPP SAPGEDLPLL VSARSPEALD EQIGRLRAYL DTGPGVDRAA
VAQTLARRTH FTHRAVLLGD TVIGAPPADQ ADELVFVYSG QGTQHPAMGE QLAAAFPVFA
DAWHDALRRL DDPDPHDPTR SQHTLFAHQA AFTALLRSWD ITPHAVIGHS LGEITAAYAA
GILSLDDACT LITTRARLMH TLPPPGAMVT VLTSEEEARQ ALRPGVEIAA VFGPHSVVLS
GDEDAVLDVA QRLGIHHRLP APHAGHSAHM EPVAAELLAT TRELRYDRPH TAIPNDPTTA
EYWAEQVRNP VLFHAHTQRY PDAVFVEIGP GQDLSPLVDG IALQNGTADE VHALHTALAR
LFTRGATLDW SRILGGASRH DPDVPSYAFQ RRPYWIESAP PATADSGHPV LGTGVAVAGS
PGRVFTGPVP AGADRAVFIA ELALAAADAT DCATVEQLDV TSVPGGSARG RATAQTWVDE
PAADGRRRFT VHTRVGDAPW TLHAEGVLRP GRVPQPEAVD TAWPPPGAVP ADGLPGAWRR
ADQVFVEAEV DSPDGFVAHP DLLDAVFSAV GDGSRQPTGW RDLAVHASDA TVLRACLTRR
DSGVVELAAF DGAGMPVLTA ESVTLGEVAS AGGSDESDGL LRLEWLPVAE AHYDGADELP
EGYTLITATH PDDPDDPTNP HNTPTRTHTQ TTRVLTALQH HLITTNHTLI VHTTTDPPGA
AVTGLTRTAQ NEHPGRIHLI ETHHPHTPLP LTQLTTLHQP HLRLTNNTLH TPHLTPITTH
HNTTTTTPNT PPLNPNHAIL ITGGSGTLAG ILARHLNHPH TYLLSRTPPP PTTPGTHIPC
DLTDPTQITQ ALTHIPQPLT GIFHTAATLD DATLTNLTPQ HLTTTLQPKA DAAWHLHHHT
QNQPLTHFVL YSSAAATLGS PGQANYAAAN AFLDALATHR HTQGQPATTI AWGMWHTTTT
LTSQLTDSDR DRIRRGGFLP ISDDEGMRLY DAAVGSGEDF VLAAAMDPAQ PMAGDVPPIL
SGLRKSARRT ARTGQTFAQR LAELPAADRD TALVTLVSDA TAAVLGHADA SGIAPTTTFK
DLGIDSLTAI ELRNRLAEAT GLRLSATMVF DHPTPRVLAA ELRTDLFGTA APLPARTART
RHDEPLAIVG MACRLPGGVT SPEDLWRLVA SGTDAITEFP TDRGWDIDRM FDPDPDAPGK
TYVRHGGFLS EAAGFDAAFF GISPREAWAM DPQQRVILET VWEAFENAGI VPDTLRGSDT
GVFMGAFSHG YGAGDDLGGF GATATQNSVL SGRLSYFFGM EGPAVTIDTA CSSSMVALHQ
AAQSLRDGEC SLALAGGVTV MPTPLGYVEF CRQRGLAPDG RAKAFAEGAD GTSFSEGAGV
LVVERLSDAE RNGHTVLALV RSSAVNQDGA SNGISAPNGP SQQRVIRQAL DKAGLAPADV
DVVEAHGTGT PLGDPIEAQA IIATYGQDRD TPLYLGSVKS NIGHTQTTAG LAGVIKMVMA
MRHGLLPKTL HVDEPSSHVD WSAGAVELLT EARPWPDSDR PRRAGVSSLG ISGTNAHVIL
EGVAESSVRS VESSGLVPLP VSARTESSLA LQVERLGEYV RGARDLAAVA DGLVRGRTVF
GHRAVLLGES TVAGVAGAES RTVFVFPGQG SQWVGMGREL MGCSEVFAAR MRECAAVLEP
YTGWDLLDVL GEAVVAERVE VLQPASWAVA VSLAALWQAH GVSPDAVIGH SQGEIAAACV
AGALSLEDAA RIVALRSQTI AAHLAGRGAM ASIALPATAV ETVEGVWVAA RNGPESTVVA
GDPSAVERVL ARYEAEGVRV RRIAVDYASH TPHVEAIQEQ LADVLGDITS SAPSVPWWST
VDGGWVTEPA GDDYWYRNLR QPVAMDTAIG ELDGSLFIEC SAHPVLLPAL DQERTVASLR
TDDGGWDRFL TALAQAWTQG ADVDWTTLIA PAPDRLLDLP TYPFDHKRYW IEATGAADLT
ALGLTDTAHP MLAATAALPT NDGTVLTGRI SLRTHPWLAD HTIQDTVLLP GTAFLELVMR
AGDEVGCDTI DELVIETPLT LPVTGAVDLT VTVEQADATG HRPVSVHARP AGTDTWTRHA
TGTLGRTEDT APDTNSFPQW PPTGPTALDV TEFYAQLAAL GYRFVPTFRG LRAAWRAGDT
VYAEVALPED RAADADHFGV HPALLDAALQ SGSLLMLESD GEQGVQLPFS WHGVRFHATG
ATSLRVAIVP GPDGLRLRAA DSENHPVATI DALVTRPPAD LAPSDPVLRV GWTAVPVPAE
VRPSDADVLM LHSDDADPIQ ETRDLTTRVL DALLTTEGTL IVQVTGGLAA MAAAGLVRTA
QSEQPGRFFL VETDPGEVLD GARCDMIAAL GEPRLRLRGN RFEAARLVRA AAALTPPDTG
SWQLRQSATG SLDDVAIVPT GEPDRPLGAG EVRIAVRAAG LNFRDDTVAL GVVADDRPLG
SEAAGVVLET GPGVHDLAPG DRVLGMLAGA FGPVAITDRR LLGRMPDGWT FPQAASVVTV
FATTWYGLVD LAELRPGEKV LIHAAATGVG AAAVQIARHL DADVYATAST PKQHLLDLEP
THIADSRTTA FADTFPPADV VLNSLTGPLL DASAQLLTPG GRFIEMGKTD IRHHVQQPFD
LMVAGPDRLQ QIITQLLDLF ANGTLHPLPV HAWDVRQARE AFGWMSSGRH TGKLVLTVPR
PLDPEGAVII TGGSGTLAGH LARHLDHPHT YLLSRTPPPD TTPGTHLPCD VSDPTQLATA
LAQIPQPLTG IFHTAATLDD ALLHNLTPQR IDTVLQPKAD AAWHLHHHTH THATDLAAFV
LYSAVAGVMG SPGQGNYVAA NAFLDALAEH RQAMGLPAQS LAWGMWADVS ALTAKLTDAD
RGRIRRGGFP PLSAADGMRL FDSAARTRSR SSSRRPSDVT RLDGPVAPLL RGLVAHRSGP
VRAVARNADD EPLAARLAGH TAAEQRRVMQ EVVLRQAAAV LAYGLGEQVA ADRPFRDLGF
DSLTAVDLRN RLAAETGLRL PTTVVFSHPT AEALATHLLE LLDAPAALTT GAPLPAVTAA
PGTAARDQDE PIAIVAMACR LPGGVTSPEE LWRLVESGTD AITTAPGDRG WDLDALYDPD
PDAVGKAYSL RGGFLEGAAE FDAAFFDISP RESLGMDPQQ RLLLETAWEA IERGRINPAS
LHGREIGVYV GAAAQGYGLG AEDTEGNAIT GGSTSLLSGR LAYVLGLEGP AVTVDTACSS
SLVALHLACQ GLRLGECELA LAGGVSVLSS PAAFVEFSRQ RGLAADGRCK SFGSGADGTT
WAEGVGVLVL EQLSDAERLG HTVLAVVRGS AVTSDGASNG LTAPNGLAQQ RVIRKALAAA
GLTAADVDLV EGHGTGTRLG DPVEADALLA TYGQNRGEPV WLGSLKSNIG HATAAAGVAG
VIKTVQAIGA GTMPRTLHAD EPSPAVDWTA GQVSLLTGNR PWPMTSVPGE RPSPRSGSAG
RTLTSSLNST VRSPWRRDRL ARNPGRCLGC CPRGPLPPCG RRPPVCAIIW RPSGPDPLDI
GYAQATSRAQ FTHRAAEEAA SPDGFRAGLD SVADGAEAPE SSAEPPRSAR RFLFDGQGAQ
RVGMGRELHG RFPVFAAAWD EVSDAFGKHL EHSPTDVFHG EHGDLAHDTL YAQVGLFTLE
VALLRLLEHW GVRPDVVVGH SVGEVTAAYA AGVLTLADAT TLIVARGRAL RALPPGAMTA
VEGSPAEVGA FTDLDIAAVN GPSAVVLTGA PDDVAAFERE WAAAGRRAKR LDVGHAFHSR
HVDGALDDFR GVLESLAFGA ARLPVVSTTT GRDAAGDLAT PEHWLRHARR PVLYADAVRE
LADLGVNMFV AVGPSGALAS AASENTGGSA GTYHAVLRAR TGEESAALTA VAELHAHGAP
VDLAAVLAGG RPVDLPVYPF QHRSYWLAPA VGGGSPTAVP DTGRPTEPDP DDLTVAEIVR
RRAAALLGIA DPGDVDADTT FFALGFDSLA VQRLRNQLTA ATGLDLPTAV LFDHDTPSAL
TAYLEEQLGD GADDDAPTVL ALLAEMDSLD AADTAATPAP ERAAIADLLD KLSRTWKDHR
//