ID   P95826_STRPY            Unreviewed;       208 AA.
AC   P95826;
DT   01-MAY-1997, integrated into UniProtKB/TrEMBL.
DT   01-MAY-1997, sequence version 1.
DT   24-JAN-2024, entry version 80.
DE   SubName: Full=M protein {ECO:0000313|EMBL:AAB40642.1};
DE   Flags: Fragment;
OS   Streptococcus pyogenes.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1314 {ECO:0000313|EMBL:AAB40642.1};
RN   [1] {ECO:0000313|EMBL:AAB40642.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=RHD152- {ECO:0000313|EMBL:AAB40642.1};
RA   Brandt E.R., Good M.F.;
RT   "Human antibodies to the conserved region of the M protein: opsonisation of
RT   heterologous strains of group A streptococci.";
RL   Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U66005; AAB40642.1; -; Genomic_DNA.
DR   AlphaFoldDB; P95826; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 6.10.250.460; -; 2.
DR   InterPro; IPR019931; LPXTG_anchor.
DR   InterPro; IPR019950; M_anchor.
DR   InterPro; IPR003345; M_repeat.
DR   NCBIfam; TIGR01167; LPXTG_anchor; 1.
DR   NCBIfam; NF033777; M_group_A_cterm; 1.
DR   Pfam; PF00746; Gram_pos_anchor; 1.
DR   Pfam; PF02370; M; 1.
DR   PRINTS; PR00015; GPOSANCHOR.
DR   PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE   4: Predicted;
KW   Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW   Secreted {ECO:0000256|ARBA:ARBA00022512};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        184..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          174..208
FT                   /note="Gram-positive cocci surface proteins LPxTG"
FT                   /evidence="ECO:0000259|PROSITE:PS50847"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          41..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          127..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        155..180
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAB40642.1"
FT   NON_TER         208
FT                   /evidence="ECO:0000313|EMBL:AAB40642.1"
SQ   SEQUENCE   208 AA;  22566 MW;  79972A987324729B CRC64;
     NKISEASRKG LRRDLDASRE AKKQVEKDLA NLTAELDKVK EEKQISDASR KGLRRDLDAS
     REAKKQVEKA LEEANSKLAA LEKLNKELEE SKKLTEKGKA ELQAKLEAEA KALKEKLAKQ
     AEELAKLRAG KASDSQTPEA TPGNKVVPGK GQAPQAGTKP NQNKAPMKET KRQLPSTGET
     ANPFFTAAAL TVMATAGVAA VVKRKEEN
//