ID P96246_MYCTU Unreviewed; 191 AA.
AC P96246; F2GDJ1; I6Y4M5; L0TGQ7;
DT 01-MAY-1997, integrated into UniProtKB/TrEMBL.
DT 01-MAY-1997, sequence version 1.
DT 24-JAN-2024, entry version 133.
DE RecName: Full=Phthiotriol/phenolphthiotriol dimycocerosates methyltransferase {ECO:0000256|ARBA:ARBA00040749};
GN OrderedLocusNames=Rv3832c {ECO:0000313|EMBL:CCP46661.1};
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332 {ECO:0000313|EMBL:CCP46661.1, ECO:0000313|Proteomes:UP000001584};
RN [1] {ECO:0000313|EMBL:CCP46661.1, ECO:0000313|Proteomes:UP000001584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv {ECO:0000313|Proteomes:UP000001584};
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III., Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L., Oliver K., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
RA Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2] {ECO:0007829|PubMed:21969609}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21969609; DOI=10.1074/mcp.M111.011445;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- FUNCTION: Catalyzes the methylation of the lipid moiety of the
CC intermediate compounds phthiotriol and glycosylated phenolphthiotriol
CC dimycoserosates to form phthiocerol dimycocerosates (DIM A) and
CC glycosylated phenolphthiocerol dimycocerosates (PGL).
CC {ECO:0000256|ARBA:ARBA00037600}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC Phthiotriol/phenolphthiotriol dimycocerosates methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00038330}.
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DR EMBL; AL123456; CCP46661.1; -; Genomic_DNA.
DR RefSeq; NP_218349.1; NC_000962.3.
DR RefSeq; WP_003420880.1; NZ_NVQJ01000022.1.
DR AlphaFoldDB; P96246; -.
DR SMR; P96246; -.
DR STRING; 83332.Rv3832c; -.
DR PaxDb; 83332-Rv3832c; -.
DR DNASU; 886165; -.
DR GeneID; 886165; -.
DR KEGG; mtu:Rv3832c; -.
DR PATRIC; fig|83332.111.peg.4259; -.
DR eggNOG; COG0500; Bacteria.
DR InParanoid; P96246; -.
DR OMA; HIGDTYN; -.
DR OrthoDB; 9805171at2; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR GO; GO:0008168; F:methyltransferase activity; IBA:GO_Central.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR013216; Methyltransf_11.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42912; METHYLTRANSFERASE; 1.
DR PANTHER; PTHR42912:SF87; PHTHIOTRIOL/PHENOLPHTHIOTRIOL DIMYCOCEROSATES METHYLTRANSFERASE; 1.
DR Pfam; PF08241; Methyltransf_11; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 1: Evidence at protein level;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000001584};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 39..133
FT /note="Methyltransferase type 11"
FT /evidence="ECO:0000259|Pfam:PF08241"
SQ SEQUENCE 191 AA; 20767 MW; 276B9FB29708DF74 CRC64;
MAMNLLHRRH CSSAGWEKAV ANQLLPWALQ HVELGPRTLE IGPGYGATLQ ALLGLTASLT
AVEVDNSMVE RLNRRYGQRA RIIRGDGTQT GLPDDHFTSV VCFTMLHHVA SAQLQDQLFA
EAYRVLQPGG VFAGSDGVPS LPFRLIHIAD TYTPIAPADL PGRLRAVGFT DIHVDVAGAR
LRWRATKPVA A
//