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Database: UniProt
Entry: P96246_MYCTU
LinkDB: P96246_MYCTU
Original site: P96246_MYCTU 
ID   P96246_MYCTU            Unreviewed;       191 AA.
AC   P96246; F2GDJ1; I6Y4M5; L0TGQ7;
DT   01-MAY-1997, integrated into UniProtKB/TrEMBL.
DT   01-MAY-1997, sequence version 1.
DT   24-JAN-2024, entry version 133.
DE   RecName: Full=Phthiotriol/phenolphthiotriol dimycocerosates methyltransferase {ECO:0000256|ARBA:ARBA00040749};
GN   OrderedLocusNames=Rv3832c {ECO:0000313|EMBL:CCP46661.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332 {ECO:0000313|EMBL:CCP46661.1, ECO:0000313|Proteomes:UP000001584};
RN   [1] {ECO:0000313|EMBL:CCP46661.1, ECO:0000313|Proteomes:UP000001584}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv {ECO:0000313|Proteomes:UP000001584};
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III., Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L., Oliver K., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
RA   Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2] {ECO:0007829|PubMed:21969609}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21969609; DOI=10.1074/mcp.M111.011445;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Catalyzes the methylation of the lipid moiety of the
CC       intermediate compounds phthiotriol and glycosylated phenolphthiotriol
CC       dimycoserosates to form phthiocerol dimycocerosates (DIM A) and
CC       glycosylated phenolphthiocerol dimycocerosates (PGL).
CC       {ECO:0000256|ARBA:ARBA00037600}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       Phthiotriol/phenolphthiotriol dimycocerosates methyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00038330}.
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DR   EMBL; AL123456; CCP46661.1; -; Genomic_DNA.
DR   RefSeq; NP_218349.1; NC_000962.3.
DR   RefSeq; WP_003420880.1; NZ_NVQJ01000022.1.
DR   AlphaFoldDB; P96246; -.
DR   SMR; P96246; -.
DR   STRING; 83332.Rv3832c; -.
DR   PaxDb; 83332-Rv3832c; -.
DR   DNASU; 886165; -.
DR   GeneID; 886165; -.
DR   KEGG; mtu:Rv3832c; -.
DR   PATRIC; fig|83332.111.peg.4259; -.
DR   eggNOG; COG0500; Bacteria.
DR   InParanoid; P96246; -.
DR   OMA; HIGDTYN; -.
DR   OrthoDB; 9805171at2; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0008168; F:methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR013216; Methyltransf_11.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR42912; METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR42912:SF87; PHTHIOTRIOL/PHENOLPHTHIOTRIOL DIMYCOCEROSATES METHYLTRANSFERASE; 1.
DR   Pfam; PF08241; Methyltransf_11; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   1: Evidence at protein level;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001584};
KW   Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT   DOMAIN          39..133
FT                   /note="Methyltransferase type 11"
FT                   /evidence="ECO:0000259|Pfam:PF08241"
SQ   SEQUENCE   191 AA;  20767 MW;  276B9FB29708DF74 CRC64;
     MAMNLLHRRH CSSAGWEKAV ANQLLPWALQ HVELGPRTLE IGPGYGATLQ ALLGLTASLT
     AVEVDNSMVE RLNRRYGQRA RIIRGDGTQT GLPDDHFTSV VCFTMLHHVA SAQLQDQLFA
     EAYRVLQPGG VFAGSDGVPS LPFRLIHIAD TYTPIAPADL PGRLRAVGFT DIHVDVAGAR
     LRWRATKPVA A
//
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