ID P96824_MYCTU Unreviewed; 506 AA.
AC P96824; F2GLU5; I6Y706; L0T5P6;
DT 01-MAY-1997, integrated into UniProtKB/TrEMBL.
DT 01-MAY-1997, sequence version 1.
DT 27-MAR-2024, entry version 155.
DE RecName: Full=Aldehyde dehydrogenase {ECO:0000256|PIRNR:PIRNR036492};
GN OrderedLocusNames=Rv0147 {ECO:0000313|EMBL:CCP42872.1};
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332 {ECO:0000313|EMBL:CCP42872.1, ECO:0000313|Proteomes:UP000001584};
RN [1] {ECO:0000313|EMBL:CCP42872.1, ECO:0000313|Proteomes:UP000001584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv {ECO:0000313|Proteomes:UP000001584};
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III., Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L., Oliver K., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
RA Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2] {ECO:0007829|PubMed:21969609}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21969609; DOI=10.1074/mcp.M111.011445;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|PIRNR:PIRNR036492,
CC ECO:0000256|RuleBase:RU003345}.
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DR EMBL; AL123456; CCP42872.1; -; Genomic_DNA.
DR RefSeq; NP_214661.1; NC_000962.3.
DR RefSeq; WP_003400974.1; NC_000962.3.
DR AlphaFoldDB; P96824; -.
DR SMR; P96824; -.
DR STRING; 83332.Rv0147; -.
DR PaxDb; 83332-Rv0147; -.
DR DNASU; 886847; -.
DR GeneID; 886847; -.
DR KEGG; mtu:Rv0147; -.
DR PATRIC; fig|83332.111.peg.169; -.
DR eggNOG; COG1012; Bacteria.
DR InParanoid; P96824; -.
DR OrthoDB; 6882680at2; -.
DR PhylomeDB; P96824; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IBA:GO_Central.
DR GO; GO:0006081; P:cellular aldehyde metabolic process; IBA:GO_Central.
DR CDD; cd07087; ALDH_F3-13-14_CALDH-like; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR012394; Aldehyde_DH_NAD(P).
DR PANTHER; PTHR43570; ALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43570:SF16; ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q; 1.
DR Pfam; PF00171; Aldedh; 1.
DR PIRSF; PIRSF036492; ALDH; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 1: Evidence at protein level;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR036492};
KW Reference proteome {ECO:0000313|Proteomes:UP000001584}.
FT DOMAIN 38..477
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 254
FT /evidence="ECO:0000256|PIRSR:PIRSR036492-1,
FT ECO:0000256|PROSITE-ProRule:PRU10007"
FT ACT_SITE 288
FT /evidence="ECO:0000256|PIRSR:PIRSR036492-1"
SQ SEQUENCE 506 AA; 55035 MW; 9181045AADAB4DF7 CRC64;
MSDRVKAVAP PDGRTMMTTE SVARKTQKSE TEAPREPAPV SDEKQTDVAK TVARLRKTFA
SGRTRSVEWR KQQLRALQKL MDENEDAIAA ALAEDLDRNP FEAYLADIAT TSAEAKYAAK
RVRRWMRRRY LLLEVPQLPG RGWVEYEPYG TVLIIGAWNY PFYLTLGPAV GAIAAGNAVV
LKPSEIAAAS AHLMTELVYR YLDTEAIAVV QGDGAVSQEL IAQGFDRVMF TGGTEIGRKV
YEGAAPHLTP VTLELGGKSP VIVAADADVD VAAKRIAWIK LLNAGQTCVA PDYVLADATV
RDELVSKITA ALTKFRSGAP QGMRIVNQRQ FDRLSGYLAA AKTDAAADGG GVVVGGDCDA
SNLRIQPTVV VDPDPDGPLM SNEIFGPILP VVTVKSLDDA IRFVNSRPKP LSAYLFTKSR
AVRERVIREV PAGGMMVNHL AFQVSTAKLP FGGVGASGMG AYHGRWGFEE FSHRKSVLTK
PTRPDLSSFI YPPYTERAIK VARRLF
//
