ID P96868_MYCTU Unreviewed; 553 AA.
AC P96868; I6XGR2; Q7D5T4;
DT 01-MAY-1997, integrated into UniProtKB/TrEMBL.
DT 01-MAY-1997, sequence version 1.
DT 27-MAR-2024, entry version 139.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Rv3263 {ECO:0000313|EMBL:CCP46082.1};
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332 {ECO:0000313|EMBL:CCP46082.1, ECO:0000313|Proteomes:UP000001584};
RN [1] {ECO:0000313|EMBL:CCP46082.1, ECO:0000313|Proteomes:UP000001584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv {ECO:0000313|Proteomes:UP000001584};
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III., Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L., Oliver K., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
RA Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; AL123456; CCP46082.1; -; Genomic_DNA.
DR RefSeq; NP_217780.1; NC_000962.3.
DR RefSeq; WP_003417095.1; NZ_NVQJ01000003.1.
DR AlphaFoldDB; P96868; -.
DR SMR; P96868; -.
DR STRING; 83332.Rv3263; -.
DR REBASE; 4230; PI-MtuHIP.
DR REBASE; 4736; M.MtuHIII.
DR REBASE; 73411; M.MtuHaORF3263P.
DR PaxDb; 83332-Rv3263; -.
DR DNASU; 888691; -.
DR GeneID; 888691; -.
DR KEGG; mtu:Rv3263; -.
DR PATRIC; fig|83332.111.peg.3645; -.
DR TubercuList; Rv3263; -.
DR eggNOG; COG0827; Bacteria.
DR InParanoid; P96868; -.
DR OrthoDB; 32195at2; -.
DR PhylomeDB; P96868; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:CCP46082.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001584};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 31..188
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 553 AA; 60673 MW; C194E4305D869631 CRC64;
MQPSHPTRPG AVIRYVGSSL DTCPMTTFAG KTAASADKVR GGYYTPPAVA RFLAHWVHQA
GPKILEPSCG DGRILRELSA ITDHAHGVEL VAREAKKSRD FASVDTENLF TWLHKTQLGS
WDGVAGNPPY IRFGNWASEQ RDPALELMRR VGLRPTKLTN AWVPFVVAST TLARDGGRVG
LVVPAELLQV TYAAQLREFL LSRYREITLV TFERLVFDGI LQEVVLFCGV VGPGPAHIRT
VRLGDANDLN ALGDKDFTNE SAPALLHEKE KWTKYFLDPA QIRLLRGLKQ SATMIRLGEL
ADVDVGIVTG RNSFFTFTDA KAQALGLRAH CVPLVSRSAQ LSGLIYDEDC RACDVAGNHR
TWLLDAADYP TDPALVAHIT AGEAAGVHLG YKCSIRKPWW STPSLWMPDL FMLRQIHFAP
RLTVNAAAAT STDTVHRVRL DPNVDPATLA AVFHNSATFA FAEIMGRSYG GGILELEPRE
AEQLPMPPPA YGSAELAQDV DLLLKANEID KALDVVDRHV LIDGLGLSPR LVAGCRAAWL
TLRDRRTKRG SRR
//
