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Database: UniProt
Entry: P97554
LinkDB: P97554
Original site: P97554 
ID   DNJB9_RAT               Reviewed;         222 AA.
AC   P97554;
DT   18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 2.
DT   19-MAR-2014, entry version 93.
DE   RecName: Full=DnaJ homolog subfamily B member 9;
DE   AltName: Full=Microvascular endothelial differentiation gene 1 protein;
DE            Short=Mdg-1;
DE   Flags: Precursor;
GN   Name=Dnajb9; Synonyms=Mdg1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Epididymis;
RX   PubMed=11525638; DOI=10.1006/excr.2001.5294;
RA   Proels F., Mayer M.P., Renner O., Czarnecki P.G., Ast M., Gaessler C.,
RA   Wilting J., Kurz H., Christ B.;
RT   "Upregulation of the cochaperone mdg1 in endothelial cells is induced
RT   by stress and during in vitro angiogenesis.";
RL   Exp. Cell Res. 269:42-53(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in endoplasmic reticulum-associated degradation
CC       (ERAD) of misfolded proteins. Acts as a co-chaperone with an Hsp70
CC       protein (By similarity).
CC   -!- SUBUNIT: Interacts with DERL1 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen (By similarity).
CC   -!- SIMILARITY: Contains 1 J domain.
CC   -!- CAUTION: Was initially reported to localize in the nucleus
CC       (PubMed:11525638). However, it was later shown to localize in the
CC       endoplasmic reticulum lumen.
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DR   EMBL; X98993; CAA67434.2; -; mRNA.
DR   EMBL; BC070915; AAH70915.1; -; mRNA.
DR   RefSeq; NP_036831.2; NM_012699.2.
DR   RefSeq; XP_006240127.1; XM_006240065.1.
DR   UniGene; Rn.29778; -.
DR   ProteinModelPortal; P97554; -.
DR   SMR; P97554; 27-105.
DR   IntAct; P97554; 6.
DR   STRING; 10116.ENSRNOP00000005363; -.
DR   Ensembl; ENSRNOT00000005363; ENSRNOP00000005363; ENSRNOG00000004006.
DR   GeneID; 24908; -.
DR   KEGG; rno:24908; -.
DR   UCSC; RGD:3070; rat.
DR   CTD; 4189; -.
DR   RGD; 3070; Dnajb9.
DR   eggNOG; COG0484; -.
DR   GeneTree; ENSGT00730000110742; -.
DR   HOGENOM; HOG000290187; -.
DR   HOVERGEN; HBG051372; -.
DR   InParanoid; P97554; -.
DR   KO; K09515; -.
DR   OMA; ATPQSIF; -.
DR   OrthoDB; EOG71CFND; -.
DR   TreeFam; TF105143; -.
DR   NextBio; 604821; -.
DR   PRO; PR:P97554; -.
DR   Genevestigator; P97554; -.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IDA:UniProtKB.
DR   GO; GO:0030433; P:ER-associated ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR018253; DnaJ_domain_CS.
DR   Pfam; PF00226; DnaJ; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   PROSITE; PS00636; DNAJ_1; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Complete proteome; Endoplasmic reticulum;
KW   Reference proteome; Signal.
FT   SIGNAL        1     23       Potential.
FT   CHAIN        24    222       DnaJ homolog subfamily B member 9.
FT                                /FTId=PRO_0000071034.
FT   DOMAIN       26     90       J.
SQ   SEQUENCE   222 AA;  25717 MW;  08BF5347F20B65DC CRC64;
     MATPQSVFVF AICILMITEL ILASKNYYDI LGVPKSASER QIKKAFHKLA MKYHPDKNKS
     PDAEAKFREI AEAYETLSDA NRRKEYDIIG HSAFTNGKGQ RSNGSPFEQS FNFNFDDLFK
     DFNLFGQNQN TRSKKHFENH FQTRQDGSSR QRHHFQEFSF GGGLFDDMFE DMEKMFSFSG
     FDSTNRRTVQ TENRFHGSSK HCRTVTQRRG NMVTTYTDCS GQ
//
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