ID MCHR1_RAT Reviewed; 360 AA.
AC P97639;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 15-AUG-2003, sequence version 3.
DT 03-APR-2013, entry version 95.
DE RecName: Full=Melanin-concentrating hormone receptor 1;
DE Short=MCH receptor 1;
DE Short=MCH-R1;
DE Short=MCHR-1;
DE AltName: Full=G-protein coupled receptor 24;
DE AltName: Full=MCH-1R;
DE Short=MCH1R;
DE Short=MCHR;
DE AltName: Full=SLC-1;
DE AltName: Full=Somatostatin receptor-like protein;
DE Flags: Fragment;
GN Name=Mchr1; Synonyms=Gpr24, Slc1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=9531978; DOI=10.1016/S0167-4889(97)00135-3;
RA Lakaye B., Minet A., Zorzi W., Grisar T.;
RT "Cloning of the rat brain cDNA encoding for the SLC-1 G protein-
RT coupled receptor reveals the presence of an intron in the gene.";
RL Biochim. Biophys. Acta 1401:216-220(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 150-307.
RX PubMed=8977118; DOI=10.1016/S0014-5793(96)01160-X;
RA Kolakowski L.F. Jr., Jung B.P., Nguyen T., Johnson M.P., Lynch K.R.,
RA Cheng R., Heng H.H.Q., George S.R., O'Dowd B.F.;
RT "Characterization of a human gene related to genes encoding
RT somatostatin receptors.";
RL FEBS Lett. 398:253-258(1996).
RN [3]
RP FUNCTION.
RX PubMed=10559938; DOI=10.1038/12978;
RA Lembo P.M.C., Grazzini E., Cao J., Hubatsch D.A., Pelletier M.,
RA Hoffert C., St Onge S., Pou C., Labrecque J., Groblewski T.,
RA O'Donnell D., Payza K., Ahmad S., Walker P.;
RT "The receptor for the orexigenic peptide melanin-concentrating hormone
RT is a G-protein-coupled receptor.";
RL Nat. Cell Biol. 1:267-271(1999).
RN [4]
RP FUNCTION.
RX PubMed=10421368; DOI=10.1038/22321;
RA Saito Y., Nothacker H.P., Wang Z., Lin S.H., Leslie F., Civelli O.;
RT "Molecular characterization of the melanin-concentrating-hormone
RT receptor.";
RL Nature 400:265-269(1999).
CC -!- FUNCTION: Receptor for melanin-concentrating hormone, coupled to G
CC proteins that inhibit adenylyl cyclase.
CC -!- SUBUNIT: Interacts with NCDN (By similarity).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: High level in the brain, moderate amounts in
CC the eye and skeletal muscle, and small amounts in tongue and
CC pituitary.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
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DR EMBL; AF008650; AAC27977.1; -; mRNA.
DR EMBL; U77953; AAC14588.1; -; Genomic_DNA.
DR IPI; IPI00206469; -.
DR RefSeq; NP_113946.1; NM_031758.1.
DR UniGene; Rn.10822; -.
DR ProteinModelPortal; P97639; -.
DR MINT; MINT-246530; -.
DR STRING; 10116.ENSRNOP00000025564; -.
DR PhosphoSite; P97639; -.
DR Ensembl; ENSRNOT00000025564; ENSRNOP00000025564; ENSRNOG00000018895.
DR GeneID; 83567; -.
DR KEGG; rno:83567; -.
DR UCSC; RGD:619841; rat.
DR CTD; 2847; -.
DR RGD; 619841; Mchr1.
DR eggNOG; NOG282817; -.
DR GeneTree; ENSGT00620000087530; -.
DR HOGENOM; HOG000000704; -.
DR HOVERGEN; HBG105726; -.
DR InParanoid; P97639; -.
DR KO; K04320; -.
DR OrthoDB; EOG43XV3F; -.
DR BindingDB; P97639; -.
DR ChEMBL; CHEMBL1075228; -.
DR NextBio; 616053; -.
DR ArrayExpress; P97639; -.
DR Genevestigator; P97639; -.
DR GermOnline; ENSRNOG00000018895; Rattus norvegicus.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0031513; C:nonmotile primary cilium; IEA:Compara.
DR GO; GO:0005886; C:plasma membrane; ISS:BHF-UCL.
DR GO; GO:0042562; F:hormone binding; IDA:RGD.
DR GO; GO:0030273; F:melanin-concentrating hormone receptor activity; IDA:RGD.
DR GO; GO:0008022; F:protein C-terminus binding; IDA:RGD.
DR GO; GO:0007204; P:elevation of cytosolic calcium ion concentration; IMP:RGD.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro.
DR GO; GO:0051928; P:positive regulation of calcium ion transport; IMP:RGD.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004047; MCH1_rcpt.
DR InterPro; IPR008361; MCH_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01507; MCH1RECEPTOR.
DR PRINTS; PR01783; MCHRECEPTOR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Complete proteome; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN <1 360 Melanin-concentrating hormone receptor 1.
FT /FTId=PRO_0000069739.
FT TOPO_DOM <1 52 Extracellular (Potential).
FT TRANSMEM 53 73 Helical; Name=1; (Potential).
FT TOPO_DOM 74 86 Cytoplasmic (Potential).
FT TRANSMEM 87 107 Helical; Name=2; (Potential).
FT TOPO_DOM 108 125 Extracellular (Potential).
FT TRANSMEM 126 146 Helical; Name=3; (Potential).
FT TOPO_DOM 147 168 Cytoplasmic (Potential).
FT TRANSMEM 169 189 Helical; Name=4; (Potential).
FT TOPO_DOM 190 211 Extracellular (Potential).
FT TRANSMEM 212 232 Helical; Name=5; (Potential).
FT TOPO_DOM 233 263 Cytoplasmic (Potential).
FT TRANSMEM 264 284 Helical; Name=6; (Potential).
FT TOPO_DOM 285 301 Extracellular (Potential).
FT TRANSMEM 302 322 Helical; Name=7; (Potential).
FT TOPO_DOM 323 360 Cytoplasmic (Potential).
FT CARBOHYD 20 20 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 23 23 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 30 30 N-linked (GlcNAc...) (Potential).
FT NON_TER 1 1
SQ SEQUENCE 360 AA; 39728 MW; B68D3C993E491350 CRC64;
QATCTGCMDL QTSLLSTGPN ASNISDGQDN LTLPGSPPRT GSVSYINIIM PSVFGTICLL
GIVGNSTVIF AVVKKSKLHW CSNVPDIFII NLSVVDLLFL LGMPFMIHQL MGNGVWHFGE
TMCTLITAMD ANSQFTSTYI LTAMTIDRYL ATVHPISSTK FRKPSMATLV ICLLWALSFI
SITPVWLYAR LIPFPGGAVG CGIRLPNPDT DLYWFTLYQF FLAFALPFVV ITAAYVKILQ
RMTSSVAPAS QRSIRLRTKR VTRTAIAICL VFFVCWAPYY VLQLTQLSIS RPTLTFVYLY
NAAISLGYAN SCLNPFVYIV LCETFRKRLV LSVKPAAQGQ LRTVSNAQTA DEERTESKGT
//
