ID LYAM1_BOVIN Reviewed; 370 AA.
AC P98131;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-APR-2013, entry version 92.
DE RecName: Full=L-selectin;
DE AltName: Full=CD62 antigen-like family member L;
DE AltName: Full=Leukocyte adhesion molecule 1;
DE Short=LAM-1;
DE AltName: Full=Leukocyte-endothelial cell adhesion molecule 1;
DE Short=LECAM1;
DE AltName: Full=Lymph node homing receptor;
DE AltName: CD_antigen=CD62L;
DE Flags: Precursor;
GN Name=SELL;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC Pecora; Bovidae; Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Lymphocyte;
RX PubMed=1371468; DOI=10.1002/eji.1830220227;
RA Walcheck B., White M., Kurk S., Kishimoto T.K., Jutila M.A.;
RT "Characterization of the bovine peripheral lymph node homing receptor:
RT a lectin cell adhesion molecule (LECAM).";
RL Eur. J. Immunol. 22:469-476(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Lymphocyte;
RX PubMed=7694420; DOI=10.1016/0165-2427(93)90194-9;
RA Bosworth B.T., Dowbenko D., Shuster D.E., Harp J.A.;
RT "Bovine L-selectin: a peripheral lymphocyte homing receptor.";
RL Vet. Immunol. Immunopathol. 37:201-215(1993).
CC -!- FUNCTION: Cell surface adhesion protein. Mediates the adherence of
CC lymphocytes to endothelial cells of high endothelial venules in
CC peripheral lymph nodes. Promotes initial tethering and rolling of
CC leukocytes in endothelia (By similarity).
CC -!- SUBUNIT: Interaction with PSGL1/SELPLG and PODXL2 is required for
CC promoting recruitment and rolling of leukocytes. This interaction
CC is dependent on the sialyl Lewis X glycan modification of PSGL1
CC and PODXL2, and tyrosine sulfation modifications of PSGL1.
CC Sulfation on 'Tyr-51' of PSGL1 is important for L-selectin binding
CC (By similarity).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC protein.
CC -!- TISSUE SPECIFICITY: Highly expressed in lymphocytes from
CC peripheral lymph nodes. Low in lymphocytes isolated from Peyer
CC patches.
CC -!- SIMILARITY: Belongs to the selectin/LECAM family.
CC -!- SIMILARITY: Contains 1 C-type lectin domain.
CC -!- SIMILARITY: Contains 1 EGF-like domain.
CC -!- SIMILARITY: Contains 2 Sushi (CCP/SCR) domains.
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DR EMBL; X62882; CAA44676.1; -; mRNA.
DR IPI; IPI00841371; -.
DR PIR; S22124; S22124.
DR RefSeq; NP_776607.1; NM_174182.1.
DR UniGene; Bt.2314; -.
DR ProteinModelPortal; P98131; -.
DR SMR; P98131; 39-194.
DR STRING; 9913.ENSBTAP00000044113; -.
DR GeneID; 281485; -.
DR KEGG; bta:281485; -.
DR CTD; 6402; -.
DR eggNOG; NOG258998; -.
DR HOGENOM; HOG000236254; -.
DR HOVERGEN; HBG052375; -.
DR KO; K06495; -.
DR OrthoDB; EOG4FFD22; -.
DR NextBio; 20805460; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; NAS:AgBase.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin.
DR InterPro; IPR016186; C-type_lectin-like.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR016187; C-type_lectin_fold.
DR InterPro; IPR000742; EG-like_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR016348; L-selectin.
DR InterPro; IPR002396; Selectin_superfamily.
DR InterPro; IPR000436; Sushi_SCR_CCP.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF00084; Sushi; 2.
DR PIRSF; PIRSF002421; L-selectin; 1.
DR PRINTS; PR00343; SELECTIN.
DR SMART; SM00032; CCP; 2.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00181; EGF; 1.
DR SUPFAM; SSF56436; C-type_lectin_fold; 1.
DR SUPFAM; SSF57535; Complement_control_module; 2.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50923; SUSHI; 2.
PE 2: Evidence at transcript level;
KW Cell adhesion; Complete proteome; Disulfide bond; EGF-like domain;
KW Glycoprotein; Lectin; Membrane; Reference proteome; Repeat; Signal;
KW Sushi; Transmembrane; Transmembrane helix.
FT SIGNAL 1 28 Potential.
FT PROPEP 29 38 Potential.
FT /FTId=PRO_0000017473.
FT CHAIN 39 370 L-selectin.
FT /FTId=PRO_0000017474.
FT TOPO_DOM 39 333 Extracellular (Potential).
FT TRANSMEM 334 354 Helical; (Potential).
FT TOPO_DOM 355 370 Cytoplasmic (Potential).
FT DOMAIN 55 155 C-type lectin.
FT DOMAIN 156 192 EGF-like.
FT DOMAIN 195 256 Sushi 1.
FT DOMAIN 257 318 Sushi 2.
FT CARBOHYD 60 60 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 77 77 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 104 104 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 177 177 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 216 216 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 226 226 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 246 246 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 308 308 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 320 320 N-linked (GlcNAc...) (Potential).
FT DISULFID 57 155 By similarity.
FT DISULFID 128 147 By similarity.
FT DISULFID 160 171 By similarity.
FT DISULFID 165 180 By similarity.
FT DISULFID 182 191 By similarity.
FT DISULFID 197 241 By similarity.
FT DISULFID 227 254 By similarity.
FT DISULFID 259 303 By similarity.
FT DISULFID 289 316 By similarity.
SQ SEQUENCE 370 AA; 41971 MW; 92168F8116AE9228 CRC64;
MLCPWKCQNA QRGLWNVFKL WVWIMLCCDF FAHHGTDCWT YHYSKRPMPW EKARAFCREN
YTDLVAIQNK GEIEYLNKTL PFSRTYYWIG IRKVEGVWTW VGTNKSLTEE AKNWGAGEPN
NRKSKEDCVE IYIKRNKDSG KWNDDACHKA KTALCYTASC KPWSCSGHGQ CVEVINNYTC
NCDLGYYGPE CQFVTQCVPL EAPKLGTMAC THPLGNFSFM SQCAFNCSKG TDMIGVEETT
CAPFGNWSSP EPTCRVIQCE PLTEPDLGTM DCNHPLVDFG FSSTCTFSCS EEAELTGEKK
TICGLSGNWS SPSPRCQKIN RTISINEESD YNPLFIPVAV MVTAFSGLAF IIWLARRLKR
KSKKVSEKHG
//
