ID LRP1_CHICK Reviewed; 4543 AA.
AC P98157;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 29-MAY-2013, entry version 107.
DE RecName: Full=Low-density lipoprotein receptor-related protein 1;
DE Short=LRP-1;
DE AltName: Full=Alpha-2-macroglobulin receptor;
DE Short=A2MR;
DE Flags: Precursor;
GN Name=LRP1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;
OC Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=White leghorn; TISSUE=Liver, and Ovary;
RX PubMed=7506255;
RA Nimpf J., Stifani S., Bilous P.T., Schneider W.J.;
RT "The somatic cell-specific low density lipoprotein receptor-related
RT protein of the chicken. Close kinship to mammalian low density
RT lipoprotein receptor gene family members.";
RL J. Biol. Chem. 269:212-219(1994).
RN [2]
RP 3D-STRUCTURE MODELING.
RX PubMed=9790844; DOI=10.1006/jmbi.1998.2115;
RA Springer T.A.;
RT "An extracellular beta-propeller module predicted in lipoprotein and
RT scavenger receptors, tyrosine kinases, epidermal growth factor
RT precursor, and extracellular matrix components.";
RL J. Mol. Biol. 283:837-862(1998).
CC -!- FUNCTION: Endocytic receptor involved in endocytosis and in
CC phagocytosis of apoptotic cells. Involved in cellular lipid
CC homeostasis. Involved in the plasma clearance of chylomicron
CC remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as
CC the local metabolism of complexes between plasminogen activators
CC and their endogenous inhibitors.
CC -!- SUBUNIT: Binds vitellogenin and LRPAP1 (alpha 2-macroglobulin).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC protein. Membrane, coated pit.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P98157-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P98157-2; Sequence=VSP_004312;
CC -!- TISSUE SPECIFICITY: Somatic.
CC -!- PTM: Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and
CC a 515 kDa large extracellular domain (LRP-515) that remains non-
CC covalently associated.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC -!- SIMILARITY: Contains 22 EGF-like domains.
CC -!- SIMILARITY: Contains 31 LDL-receptor class A domains.
CC -!- SIMILARITY: Contains 34 LDL-receptor class B repeats.
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DR EMBL; X74904; CAA52870.1; -; mRNA.
DR IPI; IPI00582419; -.
DR IPI; IPI00593211; -.
DR PIR; A53102; A53102.
DR RefSeq; NP_990573.1; NM_205242.1.
DR UniGene; Gga.689; -.
DR PDB; 1LPX; Model; -; A=3023-3282.
DR PDBsum; 1LPX; -.
DR ProteinModelPortal; P98157; -.
DR SMR; P98157; 849-891, 930-1052, 1057-1098.
DR STRING; 9031.ENSGALP00000007898; -.
DR PRIDE; P98157; -.
DR GeneID; 396170; -.
DR KEGG; gga:396170; -.
DR CTD; 4035; -.
DR eggNOG; NOG235850; -.
DR HOVERGEN; HBG006292; -.
DR KO; K04550; -.
DR NextBio; 20816224; -.
DR GO; GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR Gene3D; 2.120.10.30; -; 8.
DR Gene3D; 4.10.400.10; -; 29.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000742; EG-like_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_N_dom.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00057; Ldl_recept_a; 30.
DR Pfam; PF00058; Ldl_recept_b; 17.
DR SMART; SM00181; EGF; 17.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00192; LDLa; 31.
DR SMART; SM00135; LY; 37.
DR SUPFAM; SSF57184; Grow_fac_recept; 3.
DR SUPFAM; SSF57424; LDL_rcpt_classA_cys-rich; 29.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 8.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01209; LDLRA_1; 27.
DR PROSITE; PS50068; LDLRA_2; 31.
DR PROSITE; PS51120; LDLRB; 34.
PE 2: Evidence at transcript level;
KW 3D-structure; Alternative splicing; Calcium; Coated pit;
KW Complete proteome; Disulfide bond; EGF-like domain; Endocytosis;
KW Glycoprotein; Membrane; Metal-binding; Receptor; Reference proteome;
KW Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1 21 Potential.
FT CHAIN 22 4543 Low-density lipoprotein receptor-related
FT protein 1.
FT /FTId=PRO_0000017318.
FT TOPO_DOM 22 4419 Extracellular (Potential).
FT TRANSMEM 4420 4443 Helical; (Potential).
FT TOPO_DOM 4444 4543 Cytoplasmic (Potential).
FT DOMAIN 27 68 LDL-receptor class A 1.
FT DOMAIN 72 112 LDL-receptor class A 2.
FT DOMAIN 113 151 EGF-like 1.
FT DOMAIN 152 191 EGF-like 2; calcium-binding (Potential).
FT REPEAT 294 336 LDL-receptor class B 1.
FT REPEAT 337 380 LDL-receptor class B 2.
FT REPEAT 381 424 LDL-receptor class B 3.
FT DOMAIN 476 522 EGF-like 3.
FT REPEAT 573 615 LDL-receptor class B 4.
FT REPEAT 616 661 LDL-receptor class B 5.
FT REPEAT 662 712 LDL-receptor class B 6.
FT REPEAT 713 756 LDL-receptor class B 7.
FT DOMAIN 801 841 EGF-like 4.
FT DOMAIN 850 890 LDL-receptor class A 3.
FT DOMAIN 891 931 LDL-receptor class A 4.
FT DOMAIN 932 971 LDL-receptor class A 5.
FT DOMAIN 972 1011 LDL-receptor class A 6.
FT DOMAIN 1011 1051 LDL-receptor class A 7.
FT DOMAIN 1058 1097 LDL-receptor class A 8.
FT DOMAIN 1100 1140 LDL-receptor class A 9.
FT DOMAIN 1141 1180 LDL-receptor class A 10.
FT DOMAIN 1181 1220 EGF-like 5.
FT DOMAIN 1221 1260 EGF-like 6.
FT REPEAT 1307 1353 LDL-receptor class B 8.
FT REPEAT 1354 1396 LDL-receptor class B 9.
FT REPEAT 1397 1443 LDL-receptor class B 10.
FT REPEAT 1444 1488 LDL-receptor class B 11.
FT REPEAT 1489 1529 LDL-receptor class B 12.
FT DOMAIN 1534 1577 EGF-like 7.
FT REPEAT 1625 1667 LDL-receptor class B 13.
FT REPEAT 1668 1711 LDL-receptor class B 14.
FT REPEAT 1712 1751 LDL-receptor class B 15.
FT REPEAT 1752 1796 LDL-receptor class B 16.
FT DOMAIN 1842 1883 EGF-like 8.
FT REPEAT 1930 1972 LDL-receptor class B 17.
FT REPEAT 1973 2015 LDL-receptor class B 18.
FT REPEAT 2016 2059 LDL-receptor class B 19.
FT REPEAT 2060 2103 LDL-receptor class B 20.
FT DOMAIN 2151 2191 EGF-like 9.
FT REPEAT 2247 2288 LDL-receptor class B 21.
FT REPEAT 2289 2337 LDL-receptor class B 22.
FT REPEAT 2338 2382 LDL-receptor class B 23.
FT REPEAT 2383 2425 LDL-receptor class B 24.
FT REPEAT 2426 2467 LDL-receptor class B 25.
FT DOMAIN 2472 2512 EGF-like 10.
FT DOMAIN 2516 2557 LDL-receptor class A 11.
FT DOMAIN 2558 2596 LDL-receptor class A 12.
FT DOMAIN 2597 2635 LDL-receptor class A 13.
FT DOMAIN 2636 2684 LDL-receptor class A 14.
FT DOMAIN 2688 2730 LDL-receptor class A 15.
FT DOMAIN 2730 2769 LDL-receptor class A 16.
FT DOMAIN 2770 2812 LDL-receptor class A 17.
FT DOMAIN 2814 2853 LDL-receptor class A 18.
FT DOMAIN 2854 2897 LDL-receptor class A 19.
FT DOMAIN 2900 2938 LDL-receptor class A 20.
FT DOMAIN 2939 2978 EGF-like 11.
FT DOMAIN 2979 3019 EGF-like 12; calcium-binding (Potential).
FT REPEAT 3066 3110 LDL-receptor class B 26.
FT REPEAT 3111 3153 LDL-receptor class B 27.
FT REPEAT 3154 3197 LDL-receptor class B 28.
FT REPEAT 3198 3240 LDL-receptor class B 29.
FT REPEAT 3241 3281 LDL-receptor class B 30.
FT DOMAIN 3287 3328 EGF-like 13.
FT DOMAIN 3329 3368 LDL-receptor class A 21.
FT DOMAIN 3369 3407 LDL-receptor class A 22.
FT DOMAIN 3408 3447 LDL-receptor class A 23.
FT DOMAIN 3448 3488 LDL-receptor class A 24.
FT DOMAIN 3489 3530 LDL-receptor class A 25.
FT DOMAIN 3531 3569 LDL-receptor class A 26.
FT DOMAIN 3570 3608 LDL-receptor class A 27.
FT DOMAIN 3608 3646 LDL-receptor class A 28.
FT DOMAIN 3649 3689 LDL-receptor class A 29.
FT DOMAIN 3690 3730 LDL-receptor class A 30.
FT DOMAIN 3736 3776 LDL-receptor class A 31.
FT DOMAIN 3779 3821 EGF-like 14.
FT DOMAIN 3822 3859 EGF-like 15.
FT REPEAT 3910 3952 LDL-receptor class B 31.
FT REPEAT 3969 4011 LDL-receptor class B 32.
FT REPEAT 4012 4055 LDL-receptor class B 33.
FT REPEAT 4056 4100 LDL-receptor class B 34.
FT DOMAIN 4146 4182 EGF-like 16.
FT DOMAIN 4195 4231 EGF-like 17.
FT DOMAIN 4231 4267 EGF-like 18.
FT DOMAIN 4267 4303 EGF-like 19.
FT DOMAIN 4303 4339 EGF-like 20.
FT DOMAIN 4339 4374 EGF-like 21.
FT DOMAIN 4372 4409 EGF-like 22.
FT MOTIF 3939 3942 Recognition site for proteolytical
FT processing (Potential).
FT MOTIF 4501 4506 NPXY motif.
FT METAL 869 869 Calcium 1; via carbonyl oxygen (By
FT similarity).
FT METAL 872 872 Calcium 1 (By similarity).
FT METAL 874 874 Calcium 1; via carbonyl oxygen (By
FT similarity).
FT METAL 876 876 Calcium 1 (By similarity).
FT METAL 882 882 Calcium 1 (By similarity).
FT METAL 883 883 Calcium 1 (By similarity).
FT METAL 1030 1030 Calcium 2; via carbonyl oxygen (By
FT similarity).
FT METAL 1033 1033 Calcium 2 (By similarity).
FT METAL 1035 1035 Calcium 2; via carbonyl oxygen (By
FT similarity).
FT METAL 1037 1037 Calcium 2 (By similarity).
FT METAL 1043 1043 Calcium 2 (By similarity).
FT METAL 1044 1044 Calcium 2 (By similarity).
FT METAL 1078 1078 Calcium 3; via carbonyl oxygen (By
FT similarity).
FT METAL 1081 1081 Calcium 3 (By similarity).
FT METAL 1083 1083 Calcium 3; via carbonyl oxygen (By
FT similarity).
FT METAL 1085 1085 Calcium 3 (By similarity).
FT METAL 1091 1091 Calcium 3 (By similarity).
FT METAL 1092 1092 Calcium 3 (By similarity).
FT CARBOHYD 116 116 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 138 138 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 187 187 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 276 276 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 359 359 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 448 448 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 731 731 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 926 926 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 1048 1048 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 1152 1152 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 1153 1153 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 1193 1193 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 1216 1216 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 1305 1305 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 1509 1509 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 1556 1556 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 1573 1573 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 1614 1614 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 1643 1643 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 1721 1721 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 1731 1731 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 1761 1761 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 1823 1823 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 1929 1929 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 1991 1991 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 2044 2044 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 2113 2113 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 2123 2123 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 2466 2466 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 2496 2496 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 2515 2515 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 2595 2595 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 2614 2614 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 2632 2632 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 2813 2813 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 2903 2903 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 3045 3045 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 3086 3086 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 3176 3176 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 3261 3261 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 3330 3330 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 3485 3485 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 3659 3659 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 3786 3786 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 3837 3837 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 3952 3952 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 4074 4074 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 4124 4124 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 4178 4178 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 4278 4278 N-linked (GlcNAc...) (Potential).
FT DISULFID 29 42 By similarity.
FT DISULFID 36 55 By similarity.
FT DISULFID 49 66 By similarity.
FT DISULFID 74 87 By similarity.
FT DISULFID 81 100 By similarity.
FT DISULFID 94 110 By similarity.
FT DISULFID 117 126 By similarity.
FT DISULFID 122 135 By similarity.
FT DISULFID 137 150 By similarity.
FT DISULFID 156 166 By similarity.
FT DISULFID 162 175 By similarity.
FT DISULFID 177 190 By similarity.
FT DISULFID 480 495 By similarity.
FT DISULFID 491 506 By similarity.
FT DISULFID 508 521 By similarity.
FT DISULFID 805 816 By similarity.
FT DISULFID 812 825 By similarity.
FT DISULFID 827 840 By similarity.
FT DISULFID 852 864 By similarity.
FT DISULFID 859 877 By similarity.
FT DISULFID 871 888 By similarity.
FT DISULFID 893 905 By similarity.
FT DISULFID 900 918 By similarity.
FT DISULFID 912 929 By similarity.
FT DISULFID 934 946 By similarity.
FT DISULFID 941 959 By similarity.
FT DISULFID 953 969 By similarity.
FT DISULFID 974 987 By similarity.
FT DISULFID 982 1000 By similarity.
FT DISULFID 994 1009 By similarity.
FT DISULFID 1013 1025 By similarity.
FT DISULFID 1020 1038 By similarity.
FT DISULFID 1032 1049 By similarity.
FT DISULFID 1060 1073 By similarity.
FT DISULFID 1067 1086 By similarity.
FT DISULFID 1080 1095 By similarity.
FT DISULFID 1102 1116 By similarity.
FT DISULFID 1110 1129 By similarity.
FT DISULFID 1123 1138 By similarity.
FT DISULFID 1143 1157 By similarity.
FT DISULFID 1150 1170 By similarity.
FT DISULFID 1164 1180 By similarity.
FT DISULFID 1183 1194 By similarity.
FT DISULFID 1190 1204 By similarity.
FT DISULFID 1206 1219 By similarity.
FT DISULFID 1225 1235 By similarity.
FT DISULFID 1231 1244 By similarity.
FT DISULFID 1246 1259 By similarity.
FT DISULFID 1538 1551 By similarity.
FT DISULFID 1547 1561 By similarity.
FT DISULFID 1563 1576 By similarity.
FT DISULFID 1846 1857 By similarity.
FT DISULFID 1853 1867 By similarity.
FT DISULFID 1869 1882 By similarity.
FT DISULFID 2155 2166 By similarity.
FT DISULFID 2162 2176 By similarity.
FT DISULFID 2178 2190 By similarity.
FT DISULFID 2476 2487 By similarity.
FT DISULFID 2483 2497 By similarity.
FT DISULFID 2499 2511 By similarity.
FT DISULFID 2518 2531 By similarity.
FT DISULFID 2526 2544 By similarity.
FT DISULFID 2538 2555 By similarity.
FT DISULFID 2560 2572 By similarity.
FT DISULFID 2567 2585 By similarity.
FT DISULFID 2579 2594 By similarity.
FT DISULFID 2599 2611 By similarity.
FT DISULFID 2606 2624 By similarity.
FT DISULFID 2618 2633 By similarity.
FT DISULFID 2638 2660 By similarity.
FT DISULFID 2654 2673 By similarity.
FT DISULFID 2667 2682 By similarity.
FT DISULFID 2690 2702 By similarity.
FT DISULFID 2697 2715 By similarity.
FT DISULFID 2709 2724 By similarity.
FT DISULFID 2732 2744 By similarity.
FT DISULFID 2739 2757 By similarity.
FT DISULFID 2751 2767 By similarity.
FT DISULFID 2772 2785 By similarity.
FT DISULFID 2779 2798 By similarity.
FT DISULFID 2792 2810 By similarity.
FT DISULFID 2816 2828 By similarity.
FT DISULFID 2823 2841 By similarity.
FT DISULFID 2835 2851 By similarity.
FT DISULFID 2856 2868 By similarity.
FT DISULFID 2863 2882 By similarity.
FT DISULFID 2876 2895 By similarity.
FT DISULFID 2902 2914 By similarity.
FT DISULFID 2909 2927 By similarity.
FT DISULFID 2921 2936 By similarity.
FT DISULFID 2941 2953 By similarity.
FT DISULFID 2949 2962 By similarity.
FT DISULFID 2964 2977 By similarity.
FT DISULFID 2983 2993 By similarity.
FT DISULFID 2989 3002 By similarity.
FT DISULFID 3004 3018 By similarity.
FT DISULFID 3291 3302 By similarity.
FT DISULFID 3298 3312 By similarity.
FT DISULFID 3314 3327 By similarity.
FT DISULFID 3331 3343 By similarity.
FT DISULFID 3338 3356 By similarity.
FT DISULFID 3350 3366 By similarity.
FT DISULFID 3371 3383 By similarity.
FT DISULFID 3378 3396 By similarity.
FT DISULFID 3390 3405 By similarity.
FT DISULFID 3410 3423 By similarity.
FT DISULFID 3417 3436 By similarity.
FT DISULFID 3430 3445 By similarity.
FT DISULFID 3450 3463 By similarity.
FT DISULFID 3457 3476 By similarity.
FT DISULFID 3470 3486 By similarity.
FT DISULFID 3491 3504 By similarity.
FT DISULFID 3498 3517 By similarity.
FT DISULFID 3511 3528 By similarity.
FT DISULFID 3533 3545 By similarity.
FT DISULFID 3540 3558 By similarity.
FT DISULFID 3552 3567 By similarity.
FT DISULFID 3572 3584 By similarity.
FT DISULFID 3579 3597 By similarity.
FT DISULFID 3591 3606 By similarity.
FT DISULFID 3610 3622 By similarity.
FT DISULFID 3617 3635 By similarity.
FT DISULFID 3629 3644 By similarity.
FT DISULFID 3658 3676 By similarity.
FT DISULFID 3670 3687 By similarity.
FT DISULFID 3692 3706 By similarity.
FT DISULFID 3700 3719 By similarity.
FT DISULFID 3713 3728 By similarity.
FT DISULFID 3738 3752 By similarity.
FT DISULFID 3747 3765 By similarity.
FT DISULFID 3759 3774 By similarity.
FT DISULFID 3783 3796 By similarity.
FT DISULFID 3790 3805 By similarity.
FT DISULFID 3807 3820 By similarity.
FT DISULFID 3826 3836 By similarity.
FT DISULFID 3832 3845 By similarity.
FT DISULFID 3847 3858 By similarity.
FT DISULFID 4150 4159 By similarity.
FT DISULFID 4155 4168 By similarity.
FT DISULFID 4170 4181 By similarity.
FT DISULFID 4199 4209 By similarity.
FT DISULFID 4203 4219 By similarity.
FT DISULFID 4221 4230 By similarity.
FT DISULFID 4235 4245 By similarity.
FT DISULFID 4239 4255 By similarity.
FT DISULFID 4257 4266 By similarity.
FT DISULFID 4271 4281 By similarity.
FT DISULFID 4275 4291 By similarity.
FT DISULFID 4293 4302 By similarity.
FT DISULFID 4307 4317 By similarity.
FT DISULFID 4311 4327 By similarity.
FT DISULFID 4329 4338 By similarity.
FT DISULFID 4343 4351 By similarity.
FT DISULFID 4346 4362 By similarity.
FT DISULFID 4364 4373 By similarity.
FT DISULFID 4376 4386 By similarity.
FT DISULFID 4380 4397 By similarity.
FT DISULFID 4399 4408 By similarity.
FT VAR_SEQ 2725 2729 SERQD -> N (in isoform 2).
FT /FTId=VSP_004312.
FT STRAND 3028 3040
FT TURN 3041 3044
FT STRAND 3045 3051
FT STRAND 3056 3061
FT STRAND 3065 3073
FT STRAND 3080 3084
FT TURN 3085 3087
FT STRAND 3088 3094
FT STRAND 3101 3108
FT TURN 3109 3111
FT STRAND 3112 3127
FT TURN 3128 3131
FT STRAND 3132 3138
FT STRAND 3144 3149
FT STRAND 3153 3160
FT TURN 3161 3164
FT STRAND 3166 3171
FT HELIX 3172 3174
FT STRAND 3176 3181
FT STRAND 3188 3193
FT STRAND 3197 3204
FT STRAND 3207 3214
FT TURN 3215 3218
FT STRAND 3219 3225
FT STRAND 3231 3245
FT STRAND 3248 3255
FT TURN 3256 3259
FT STRAND 3260 3266
FT STRAND 3272 3277
SQ SEQUENCE 4543 AA; 507133 MW; C8D5823BB868BAD5 CRC64;
MGPLLALAGC LLALLAAPAA RALEAPKTCS PKQFACKDQI TCISKGWRCD GEKDCPDGSD
ESPDICPQSK VSRCQPNEHN CLGTELCIHM SKLCNGLHDC FDGSDEGPHC REQLANCTAL
GCQHHCVPTL SGPACYCNNS FQLAEDRRSC KDFDECTVYG TCSQTCTNTE GSYTCSCVEG
YLLQPDNRSC KAKNEPVDRP PVLLIANSQN ILATYLSGAP VPNITPTSAK QTTAMDFNYI
EDTVCWVHVG DSASQTILKC AKIPNLKGFV EERSINISLS LHQVEQMAID WLTGNFYFVD
DIDDRIFVCN KNGLTCVTLL DLELYNPKGI ALDPAMGKVF FTDYGQIPKV ERCDMDGQNR
TKLVDSKIVF PHGITLDLVS RLVYWADAYL DYIEVVDYEG KNRHTIIQGI LIEHLYGLTV
FENYLYATNS DNANAQQKTS VIRVNRFNST EYQVVTRVDK GGALHIYHQR RQPTVRSHAC
EPDQFGKPGG CSDICLLGNS HKSRTCRCRS GFSLGSDGKS CKKPEHELFL VYGKGRPGII
RGMDMGAKVP DEHMIPIENL MNPRALDFHA ETGFIYFADT TSYLIGRQKI DGTERETILK
DGIHNVEGIA VDWMGNNLYW TDDGPKKTIS VARLEKAAQT RKTLIEGKMT HPRAIVVDPL
NGWMYWTDWE EDPKDSKRGK IERAWMDGSN RNVFITSKTV LWPNGLSLDI PAKILYWVDA
FYDRIEMVYL NGTERKIVYE GPELNHAFGL CHYSSFLFWT EYRSGSIYRL DQSSKAVSLL
RNERPPIFEI RMYDAQQQQV GSNKCRVNNG GCSSLCLATP RGRQCACAED QILGADSVTC
EANPSYIPPP QCQPGEFACK NNRCIQERWK CDGDNDCLDN SDEAPELCHQ HTCPSDRFKC
KNNRCIPNRW LCDGDNDCGN NEDESNSTCS ARTCSPNQFS CASGRCIPIS WTCDLDDDCG
DRSDESASCA YPTCFPLTQF TCNNGRCINI NWRCDNDNDC GDNSDEAGCS HSCSSNQFKC
NSGRCIPVHW TCDGDNDCGD YSDETHANCT NQATRPPGGC HTDEFQCRLD GLCIPMRWRC
DGDTDCMDSS DEKNCEGVTH VCDPNVKFGC KDSARCISKA WVCDGDSDCE DNSDEENCES
LVCKPPSHTC ANNTSICLPP EKLCDGSDDC GDGSDEGELC DQCSLNNGGC SHNCTVAPGE
GIVCSCPLGM ELGADNKTCQ IQSYCAKHLK CSQKCEQDKY NVKCSCYEGW MLEPDGESCR
SLDPFKPFII FSNRHEIRRI DLHRGDYSVL VPGLRNTIAL DFHLNQSSLY WTDVVEDKIY
RGKLLENGAL TSFEVVIQYG LATPEGLAVD WIAGNIYWVE SNLDQIEVAK LDGTMRTTLL
AGDIEHPRAI ALDPRYGILF WTDWDASLPR IEAASMSGAG RRTIHKETGS GGWPNGLTVD
YLEKRILWID ARSDAIYSAL YDGTGHIEVL RGHEYLSHPF AVTLYGGEVY WTDWRTNTLA
KANKWTGHNV TVVQRTNTQP FDLQVYHPSR QPLAPNPCEA NGGKGPCSHL CLINYNRTLS
CACPHLMKLD KDNTTCYEFK KFLLYARQME IRGVDIDNPY YNYIISFTVP DIDNVTVVDY
DAVEQRIYWS DVRTQTIKRA FINGTGVETV VSADLPNAHG LSVDWVSRNL FWTSYDTNKK
QINVARLDGS FKNAVIQGLD KPHCLVVHPL HGKLYWTDGD NISVANMDGS NRTLLFTNQR
GPVGLAIDYP ESKLYWISSG NGTINRCNLD GSDLEVIVAV KSQLSKATAL AIMGDKLWWA
DQASERMGTC NKKDGTEVTV LRNSTTLVML MKVYDESIQQ AGSNPCSVNN GDCSQLCLPT
SETSRSCMCT AGYSLKSGQQ SCEGVGSFLL YSVHEGIRGI PLDPNDKSDA LVPVSGTSLA
VGIDFHAEND TIYWVDMGLS TISRAKRDQT WREDVVTNGI GRVEGIAVDW IAGNIYWTDQ
GFDVIEVARL NGSFRYVVIS QGLDKPRAIT VHPEKGYLFW TEWGQYPRIE RSRLDGTERM
VLVNVSISWP NGISVDYEDG KLYWCDARTD KIERIDLETG ENREVVLSSD NMDMFSVSVF
EDYIYWSDRT HANGSIKRGS KDNATESVSL RTGIGVQLKD IKVFNRARQK GTNVCAQNNG
GCQQLCLFRG GGRRTCACAH GMLSEDGVSC RDYDGYLLYS ERTILKSIHL SDENNLNAPI
KPFEDAEHMK NVIALAFDYR YGTKGSNRIF YSDIHFGNIQ QINDDGTGRR TIVENVGSVE
GLAYHRGWDT LYWTSYTTST ITRHTVDQSR LGAFERETVI TMSGDDHPRA FVLDECQNLM
FWTNWNEQHP SIMRATLSGA NVLIIIDQDI RTPNGLAIDH RAEKIYFSDA TLDKIERCEY
DGSHRHVILK SEPVHPFGLA VYGDYIFWTD WVRRAVQRAN KYVGTDMKLL RVDIPQQPMG
IIAVANDTDS CELSPCRVNN GGCQDLCLLT PKGHVNCSCR GERVLQEDFT CKALNSTCNV
HDEFECGNGD CIDFSRTCDG VVHCKDKSDE KQSYCSSRKC KKGFLHCMNG RCVASRFWCN
GVDDCGDNSD EVPCNKTSCA ATEFRCRDGS CIGNSSRCNQ FIDCEDASDE MNCTATDCSS
YFKLGVKGTT FQKCEHTSLC YAPSWVCDGA NDCGDYSDER NCPGGRKPKC PANYFACPSG
RCIPMTWTCD KEDDCENGED ETHCSERQDK FCYPVQFECN NHRCISKLWV CDGADDCGDG
SDEDSRCRLT TCSTGSFQCP GTYVCVPERW LCDGDKDCAD GADETLAAGC LYNNTCDERE
FMCGNRQCIP KHFVCDHDDD CGDGSDESPE CEYPTCGPHE FRCANGRCLS NSQWECDGEF
DCHDHSDEAP KNPRCSSPES KCNDSFFMCK NGKCIPEALL CDNNNDCADG SDELNCFINE
CLNKKLSGCS QECEDLKIGY KCRCRPGFRL KDDGKTCIDI DECSTTYPCS QKCINTLGSY
KCLCIEGYKL KPDNPTSCKA VTDEEPFLIF ANRYYLRKLN LDGSNYTLLK QGLNNAVALD
FDYREQMIYW TDVTTQGSMI RRMHINGSNV QVLHRTGLSN PDGLAVDWVG GNLYWCDKGR
DTIEVSKLNG AYRTVLVNSG LREPRALVVD VQNGYLYWTD WGDHSLIGKI GMDGTNRSVI
VDTKITWPNG LTLDYINSRI YWADAREDYI EFASLDGSNR HTVLSQDIPH IFALTLFEDY
IYWTDWETKS INRAHKTTGA NKTLLISTLH RPMDIHIYHP YRQPDVPNHP CKTNNAGCSN
LCLLSPGGGH KCACPTNFYL GSDGKTCVSN CTASQFVCKN DKCIPFWWKC DTEDDCGDRS
DEPEDCPEFK CRPGQFQCST GICTNPAFIC DGDNDCQDNS DEANCDIHVC LPSQFKCTNT
NRCIPGIFRC NGQDNCGDGE DEKDCPEVTC APNQFQCAIT KRCIPRVWVC DRDNDCVDGS
DEPANCTQMT CGVDEFRCKD SGRCIPARWK CDGEDDCGDG SDEPKEECDE RTCEPYQFRC
KNNRCVPGRW QCDYDNDCGD NSDEESCTPR PCSESEFSCA NGRCIAGRWK CDGDHDCADG
SDEKDCIPRC EFDQYQCKNG HCIPMRWRCD ADADCMDGTD EEDCGTGVRT CPLDEFQCNN
TLRKPLAWKC DGEDDCGDNS DENPEECLKF QCPPNRPFRC KNDRVCLWIG RQCDGIDNCG
DNTDEKDCES PTAKPKSCSQ DKNEFLCENK KCISANLRCN FFDDCGDGSD EKSCSHEHKS
YDCMTNTTMC GDEAQCIQAQ SSTYCTCRRG FQKVPDKNSC QDVNECLRFG TCSQLCNNTK
GSHVCSCAKN FMKTDNMCKA EGSEHQILYI ADDNKIRSMY PFNPNSAYEP AFQGDENVRI
DAMDIYVKGN KIYWTNWHTG RISYCELPAS SAASTASNRN RRQIDGGVTH LNISGLKMPR
GIAVDWVAGN IYWTDSGRDV IEVAQMKGEN RKTLISGMID EPHAIVVDPL RGTMYWSDWG
NHPKIETAAM DGTLRETLVQ DNIQWPTGLA VDYHNERLYW ADAKLSVIGS IRLNGTDPVV
AIDNKKGLSH PFSIDIFEDY IYGVTYINNR IFKIHKFGHK SVTNLTSGLN HATDVVLYHQ
YKQPEVTNPC DRKKCEWLCL LSPSGPVCTC PNGKRLDNGT CVLIPSPTAS AVVPTTDTCD
LVCLNGGSCF LNARKQAKCR CQPRYNGERC QINQCSDYCQ NGGLCTASPS GMPTCRCPTG
FTGSRCDQQV CTNYCHNNGS CTVNQGNQPN CRCPPTFIGD RCQYQQCFNY CENNGVCQMS
RDGVKQCRCP PQFEGAQCQD NKCSRCQEGK CNINRQSGDV SCICPDGKIA PSCLTCDSYC
LNGGTCSISD KTQLPECLCP LEVTGMRCEE FIVGEQQSGR TASIVIPILL LLLLLAVVAF
AWYKWRIKGA KGFQHQRMTN GAMNVEIGNP TYKMYEGEPD DDVGELLDAD FALDPDKPTN
FTNPVYATLY MGAHSSRNSL ASTDEKRELL ARGADDDLTD PLA
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