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Database: UniProt
Entry: P98157
LinkDB: P98157
Original site: P98157 
ID   LRP1_CHICK              Reviewed;        4543 AA.
AC   P98157;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   26-NOV-2014, entry version 117.
DE   RecName: Full=Low-density lipoprotein receptor-related protein 1;
DE            Short=LRP-1;
DE   AltName: Full=Alpha-2-macroglobulin receptor;
DE            Short=A2MR;
DE   Flags: Precursor;
GN   Name=LRP1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Testudines + Archosauria group; Archosauria; Dinosauria; Saurischia;
OC   Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=White leghorn; TISSUE=Liver, and Ovary;
RX   PubMed=7506255;
RA   Nimpf J., Stifani S., Bilous P.T., Schneider W.J.;
RT   "The somatic cell-specific low density lipoprotein receptor-related
RT   protein of the chicken. Close kinship to mammalian low density
RT   lipoprotein receptor gene family members.";
RL   J. Biol. Chem. 269:212-219(1994).
RN   [2]
RP   3D-STRUCTURE MODELING.
RX   PubMed=9790844; DOI=10.1006/jmbi.1998.2115;
RA   Springer T.A.;
RT   "An extracellular beta-propeller module predicted in lipoprotein and
RT   scavenger receptors, tyrosine kinases, epidermal growth factor
RT   precursor, and extracellular matrix components.";
RL   J. Mol. Biol. 283:837-862(1998).
CC   -!- FUNCTION: Endocytic receptor involved in endocytosis and in
CC       phagocytosis of apoptotic cells. Involved in cellular lipid
CC       homeostasis. Involved in the plasma clearance of chylomicron
CC       remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as
CC       the local metabolism of complexes between plasminogen activators
CC       and their endogenous inhibitors.
CC   -!- SUBUNIT: Binds vitellogenin and LRPAP1 (alpha 2-macroglobulin).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein. Membrane, coated pit.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P98157-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P98157-2; Sequence=VSP_004312;
CC   -!- TISSUE SPECIFICITY: Somatic.
CC   -!- PTM: Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and
CC       a 515 kDa large extracellular domain (LRP-515) that remains non-
CC       covalently associated.
CC   -!- SIMILARITY: Belongs to the LDLR family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 22 EGF-like domains. {ECO:0000255|PROSITE-
CC       ProRule:PRU00076}.
CC   -!- SIMILARITY: Contains 31 LDL-receptor class A domains.
CC       {ECO:0000255|PROSITE-ProRule:PRU00124}.
CC   -!- SIMILARITY: Contains 34 LDL-receptor class B repeats.
CC       {ECO:0000255|PROSITE-ProRule:PRU00461}.
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DR   EMBL; X74904; CAA52870.1; -; mRNA.
DR   PIR; A53102; A53102.
DR   RefSeq; NP_990573.1; NM_205242.1. [P98157-1]
DR   UniGene; Gga.689; -.
DR   PDB; 1LPX; Model; -; A=3023-3282.
DR   PDBsum; 1LPX; -.
DR   ProteinModelPortal; P98157; -.
DR   SMR; P98157; 849-891, 930-1052, 1057-1098.
DR   STRING; 9031.ENSGALP00000007898; -.
DR   PRIDE; P98157; -.
DR   GeneID; 396170; -.
DR   KEGG; gga:396170; -.
DR   CTD; 4035; -.
DR   eggNOG; NOG235850; -.
DR   HOVERGEN; HBG006292; -.
DR   InParanoid; P98157; -.
DR   KO; K04550; -.
DR   PhylomeDB; P98157; -.
DR   NextBio; 20816224; -.
DR   PRO; PR:P98157; -.
DR   GO; GO:0005905; C:coated pit; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR   Gene3D; 2.120.10.30; -; 8.
DR   Gene3D; 4.10.400.10; -; 29.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR026823; cEGF.
DR   InterPro; IPR000742; EG-like_dom.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_N_dom.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR000033; LDLR_classB_rpt.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   Pfam; PF12662; cEGF; 1.
DR   Pfam; PF00008; EGF; 1.
DR   Pfam; PF00057; Ldl_recept_a; 30.
DR   Pfam; PF00058; Ldl_recept_b; 17.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00181; EGF; 17.
DR   SMART; SM00179; EGF_CA; 3.
DR   SMART; SM00192; LDLa; 31.
DR   SMART; SM00135; LY; 37.
DR   SUPFAM; SSF57184; SSF57184; 6.
DR   SUPFAM; SSF57424; SSF57424; 30.
DR   PROSITE; PS00010; ASX_HYDROXYL; 3.
DR   PROSITE; PS00022; EGF_1; 5.
DR   PROSITE; PS01186; EGF_2; 7.
DR   PROSITE; PS50026; EGF_3; 8.
DR   PROSITE; PS01187; EGF_CA; 2.
DR   PROSITE; PS01209; LDLRA_1; 27.
DR   PROSITE; PS50068; LDLRA_2; 31.
DR   PROSITE; PS51120; LDLRB; 34.
PE   2: Evidence at transcript level;
KW   3D-structure; Alternative splicing; Calcium; Coated pit;
KW   Complete proteome; Disulfide bond; EGF-like domain; Endocytosis;
KW   Glycoprotein; Membrane; Metal-binding; Receptor; Reference proteome;
KW   Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     21       {ECO:0000255}.
FT   CHAIN        22   4543       Low-density lipoprotein receptor-related
FT                                protein 1.
FT                                /FTId=PRO_0000017318.
FT   TOPO_DOM     22   4419       Extracellular. {ECO:0000255}.
FT   TRANSMEM   4420   4443       Helical. {ECO:0000255}.
FT   TOPO_DOM   4444   4543       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       27     68       LDL-receptor class A 1.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN       72    112       LDL-receptor class A 2.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN      113    151       EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      152    191       EGF-like 2; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   REPEAT      294    336       LDL-receptor class B 1.
FT   REPEAT      337    380       LDL-receptor class B 2.
FT   REPEAT      381    424       LDL-receptor class B 3.
FT   DOMAIN      476    522       EGF-like 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT      573    615       LDL-receptor class B 4.
FT   REPEAT      616    661       LDL-receptor class B 5.
FT   REPEAT      662    712       LDL-receptor class B 6.
FT   REPEAT      713    756       LDL-receptor class B 7.
FT   DOMAIN      801    841       EGF-like 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      850    890       LDL-receptor class A 3.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN      891    931       LDL-receptor class A 4.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN      932    971       LDL-receptor class A 5.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN      972   1011       LDL-receptor class A 6.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1011   1051       LDL-receptor class A 7.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1058   1097       LDL-receptor class A 8.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1100   1140       LDL-receptor class A 9.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1141   1180       LDL-receptor class A 10.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1181   1220       EGF-like 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     1221   1260       EGF-like 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT     1307   1353       LDL-receptor class B 8.
FT   REPEAT     1354   1396       LDL-receptor class B 9.
FT   REPEAT     1397   1443       LDL-receptor class B 10.
FT   REPEAT     1444   1488       LDL-receptor class B 11.
FT   REPEAT     1489   1529       LDL-receptor class B 12.
FT   DOMAIN     1534   1577       EGF-like 7. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT     1625   1667       LDL-receptor class B 13.
FT   REPEAT     1668   1711       LDL-receptor class B 14.
FT   REPEAT     1712   1751       LDL-receptor class B 15.
FT   REPEAT     1752   1796       LDL-receptor class B 16.
FT   DOMAIN     1842   1883       EGF-like 8. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT     1930   1972       LDL-receptor class B 17.
FT   REPEAT     1973   2015       LDL-receptor class B 18.
FT   REPEAT     2016   2059       LDL-receptor class B 19.
FT   REPEAT     2060   2103       LDL-receptor class B 20.
FT   DOMAIN     2151   2191       EGF-like 9. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT     2247   2288       LDL-receptor class B 21.
FT   REPEAT     2289   2337       LDL-receptor class B 22.
FT   REPEAT     2338   2382       LDL-receptor class B 23.
FT   REPEAT     2383   2425       LDL-receptor class B 24.
FT   REPEAT     2426   2467       LDL-receptor class B 25.
FT   DOMAIN     2472   2512       EGF-like 10. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     2516   2557       LDL-receptor class A 11.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2558   2596       LDL-receptor class A 12.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2597   2635       LDL-receptor class A 13.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2636   2684       LDL-receptor class A 14.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2688   2730       LDL-receptor class A 15.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2730   2769       LDL-receptor class A 16.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2770   2812       LDL-receptor class A 17.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2814   2853       LDL-receptor class A 18.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2854   2897       LDL-receptor class A 19.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2900   2938       LDL-receptor class A 20.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2939   2978       EGF-like 11. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     2979   3019       EGF-like 12; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   REPEAT     3066   3110       LDL-receptor class B 26.
FT   REPEAT     3111   3153       LDL-receptor class B 27.
FT   REPEAT     3154   3197       LDL-receptor class B 28.
FT   REPEAT     3198   3240       LDL-receptor class B 29.
FT   REPEAT     3241   3281       LDL-receptor class B 30.
FT   DOMAIN     3287   3328       EGF-like 13. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     3329   3368       LDL-receptor class A 21.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3369   3407       LDL-receptor class A 22.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3408   3447       LDL-receptor class A 23.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3448   3488       LDL-receptor class A 24.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3489   3530       LDL-receptor class A 25.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3531   3569       LDL-receptor class A 26.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3570   3608       LDL-receptor class A 27.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3608   3646       LDL-receptor class A 28.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3649   3689       LDL-receptor class A 29.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3690   3730       LDL-receptor class A 30.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3736   3776       LDL-receptor class A 31.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3779   3821       EGF-like 14. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     3822   3859       EGF-like 15. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT     3910   3952       LDL-receptor class B 31.
FT   REPEAT     3969   4011       LDL-receptor class B 32.
FT   REPEAT     4012   4055       LDL-receptor class B 33.
FT   REPEAT     4056   4100       LDL-receptor class B 34.
FT   DOMAIN     4146   4182       EGF-like 16. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     4195   4231       EGF-like 17. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     4231   4267       EGF-like 18. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     4267   4303       EGF-like 19. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     4303   4339       EGF-like 20. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     4339   4374       EGF-like 21. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     4372   4409       EGF-like 22. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   MOTIF      3939   3942       Recognition site for proteolytical
FT                                processing. {ECO:0000255}.
FT   MOTIF      4501   4506       NPXY motif.
FT   METAL       869    869       Calcium 1; via carbonyl oxygen.
FT                                {ECO:0000250}.
FT   METAL       872    872       Calcium 1. {ECO:0000250}.
FT   METAL       874    874       Calcium 1; via carbonyl oxygen.
FT                                {ECO:0000250}.
FT   METAL       876    876       Calcium 1. {ECO:0000250}.
FT   METAL       882    882       Calcium 1. {ECO:0000250}.
FT   METAL       883    883       Calcium 1. {ECO:0000250}.
FT   METAL      1030   1030       Calcium 2; via carbonyl oxygen.
FT                                {ECO:0000250}.
FT   METAL      1033   1033       Calcium 2. {ECO:0000250}.
FT   METAL      1035   1035       Calcium 2; via carbonyl oxygen.
FT                                {ECO:0000250}.
FT   METAL      1037   1037       Calcium 2. {ECO:0000250}.
FT   METAL      1043   1043       Calcium 2. {ECO:0000250}.
FT   METAL      1044   1044       Calcium 2. {ECO:0000250}.
FT   METAL      1078   1078       Calcium 3; via carbonyl oxygen.
FT                                {ECO:0000250}.
FT   METAL      1081   1081       Calcium 3. {ECO:0000250}.
FT   METAL      1083   1083       Calcium 3; via carbonyl oxygen.
FT                                {ECO:0000250}.
FT   METAL      1085   1085       Calcium 3. {ECO:0000250}.
FT   METAL      1091   1091       Calcium 3. {ECO:0000250}.
FT   METAL      1092   1092       Calcium 3. {ECO:0000250}.
FT   CARBOHYD    116    116       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    138    138       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    187    187       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    276    276       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    359    359       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    448    448       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    731    731       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    926    926       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   1048   1048       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   1152   1152       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   1153   1153       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   1193   1193       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   1216   1216       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   1305   1305       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   1509   1509       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   1556   1556       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   1573   1573       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   1614   1614       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   1643   1643       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   1721   1721       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   1731   1731       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   1761   1761       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   1823   1823       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   1929   1929       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   1991   1991       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   2044   2044       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   2113   2113       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   2123   2123       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   2466   2466       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   2496   2496       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   2515   2515       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   2595   2595       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   2614   2614       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   2632   2632       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   2813   2813       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   2903   2903       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   3045   3045       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   3086   3086       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   3176   3176       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   3261   3261       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   3330   3330       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   3485   3485       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   3659   3659       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   3786   3786       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   3837   3837       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   3952   3952       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   4074   4074       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   4124   4124       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   4178   4178       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   4278   4278       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID     29     42       {ECO:0000250}.
FT   DISULFID     36     55       {ECO:0000250}.
FT   DISULFID     49     66       {ECO:0000250}.
FT   DISULFID     74     87       {ECO:0000250}.
FT   DISULFID     81    100       {ECO:0000250}.
FT   DISULFID     94    110       {ECO:0000250}.
FT   DISULFID    117    126       {ECO:0000250}.
FT   DISULFID    122    135       {ECO:0000250}.
FT   DISULFID    137    150       {ECO:0000250}.
FT   DISULFID    156    166       {ECO:0000250}.
FT   DISULFID    162    175       {ECO:0000250}.
FT   DISULFID    177    190       {ECO:0000250}.
FT   DISULFID    480    495       {ECO:0000250}.
FT   DISULFID    491    506       {ECO:0000250}.
FT   DISULFID    508    521       {ECO:0000250}.
FT   DISULFID    805    816       {ECO:0000250}.
FT   DISULFID    812    825       {ECO:0000250}.
FT   DISULFID    827    840       {ECO:0000250}.
FT   DISULFID    852    864       {ECO:0000250}.
FT   DISULFID    859    877       {ECO:0000250}.
FT   DISULFID    871    888       {ECO:0000250}.
FT   DISULFID    893    905       {ECO:0000250}.
FT   DISULFID    900    918       {ECO:0000250}.
FT   DISULFID    912    929       {ECO:0000250}.
FT   DISULFID    934    946       {ECO:0000250}.
FT   DISULFID    941    959       {ECO:0000250}.
FT   DISULFID    953    969       {ECO:0000250}.
FT   DISULFID    974    987       {ECO:0000250}.
FT   DISULFID    982   1000       {ECO:0000250}.
FT   DISULFID    994   1009       {ECO:0000250}.
FT   DISULFID   1013   1025       {ECO:0000250}.
FT   DISULFID   1020   1038       {ECO:0000250}.
FT   DISULFID   1032   1049       {ECO:0000250}.
FT   DISULFID   1060   1073       {ECO:0000250}.
FT   DISULFID   1067   1086       {ECO:0000250}.
FT   DISULFID   1080   1095       {ECO:0000250}.
FT   DISULFID   1102   1116       {ECO:0000250}.
FT   DISULFID   1110   1129       {ECO:0000250}.
FT   DISULFID   1123   1138       {ECO:0000250}.
FT   DISULFID   1143   1157       {ECO:0000250}.
FT   DISULFID   1150   1170       {ECO:0000250}.
FT   DISULFID   1164   1180       {ECO:0000250}.
FT   DISULFID   1183   1194       {ECO:0000250}.
FT   DISULFID   1190   1204       {ECO:0000250}.
FT   DISULFID   1206   1219       {ECO:0000250}.
FT   DISULFID   1225   1235       {ECO:0000250}.
FT   DISULFID   1231   1244       {ECO:0000250}.
FT   DISULFID   1246   1259       {ECO:0000250}.
FT   DISULFID   1538   1551       {ECO:0000250}.
FT   DISULFID   1547   1561       {ECO:0000250}.
FT   DISULFID   1563   1576       {ECO:0000250}.
FT   DISULFID   1846   1857       {ECO:0000250}.
FT   DISULFID   1853   1867       {ECO:0000250}.
FT   DISULFID   1869   1882       {ECO:0000250}.
FT   DISULFID   2155   2166       {ECO:0000250}.
FT   DISULFID   2162   2176       {ECO:0000250}.
FT   DISULFID   2178   2190       {ECO:0000250}.
FT   DISULFID   2476   2487       {ECO:0000250}.
FT   DISULFID   2483   2497       {ECO:0000250}.
FT   DISULFID   2499   2511       {ECO:0000250}.
FT   DISULFID   2518   2531       {ECO:0000250}.
FT   DISULFID   2526   2544       {ECO:0000250}.
FT   DISULFID   2538   2555       {ECO:0000250}.
FT   DISULFID   2560   2572       {ECO:0000250}.
FT   DISULFID   2567   2585       {ECO:0000250}.
FT   DISULFID   2579   2594       {ECO:0000250}.
FT   DISULFID   2599   2611       {ECO:0000250}.
FT   DISULFID   2606   2624       {ECO:0000250}.
FT   DISULFID   2618   2633       {ECO:0000250}.
FT   DISULFID   2638   2660       {ECO:0000250}.
FT   DISULFID   2654   2673       {ECO:0000250}.
FT   DISULFID   2667   2682       {ECO:0000250}.
FT   DISULFID   2690   2702       {ECO:0000250}.
FT   DISULFID   2697   2715       {ECO:0000250}.
FT   DISULFID   2709   2724       {ECO:0000250}.
FT   DISULFID   2732   2744       {ECO:0000250}.
FT   DISULFID   2739   2757       {ECO:0000250}.
FT   DISULFID   2751   2767       {ECO:0000250}.
FT   DISULFID   2772   2785       {ECO:0000250}.
FT   DISULFID   2779   2798       {ECO:0000250}.
FT   DISULFID   2792   2810       {ECO:0000250}.
FT   DISULFID   2816   2828       {ECO:0000250}.
FT   DISULFID   2823   2841       {ECO:0000250}.
FT   DISULFID   2835   2851       {ECO:0000250}.
FT   DISULFID   2856   2868       {ECO:0000250}.
FT   DISULFID   2863   2882       {ECO:0000250}.
FT   DISULFID   2876   2895       {ECO:0000250}.
FT   DISULFID   2902   2914       {ECO:0000250}.
FT   DISULFID   2909   2927       {ECO:0000250}.
FT   DISULFID   2921   2936       {ECO:0000250}.
FT   DISULFID   2941   2953       {ECO:0000250}.
FT   DISULFID   2949   2962       {ECO:0000250}.
FT   DISULFID   2964   2977       {ECO:0000250}.
FT   DISULFID   2983   2993       {ECO:0000250}.
FT   DISULFID   2989   3002       {ECO:0000250}.
FT   DISULFID   3004   3018       {ECO:0000250}.
FT   DISULFID   3291   3302       {ECO:0000250}.
FT   DISULFID   3298   3312       {ECO:0000250}.
FT   DISULFID   3314   3327       {ECO:0000250}.
FT   DISULFID   3331   3343       {ECO:0000250}.
FT   DISULFID   3338   3356       {ECO:0000250}.
FT   DISULFID   3350   3366       {ECO:0000250}.
FT   DISULFID   3371   3383       {ECO:0000250}.
FT   DISULFID   3378   3396       {ECO:0000250}.
FT   DISULFID   3390   3405       {ECO:0000250}.
FT   DISULFID   3410   3423       {ECO:0000250}.
FT   DISULFID   3417   3436       {ECO:0000250}.
FT   DISULFID   3430   3445       {ECO:0000250}.
FT   DISULFID   3450   3463       {ECO:0000250}.
FT   DISULFID   3457   3476       {ECO:0000250}.
FT   DISULFID   3470   3486       {ECO:0000250}.
FT   DISULFID   3491   3504       {ECO:0000250}.
FT   DISULFID   3498   3517       {ECO:0000250}.
FT   DISULFID   3511   3528       {ECO:0000250}.
FT   DISULFID   3533   3545       {ECO:0000250}.
FT   DISULFID   3540   3558       {ECO:0000250}.
FT   DISULFID   3552   3567       {ECO:0000250}.
FT   DISULFID   3572   3584       {ECO:0000250}.
FT   DISULFID   3579   3597       {ECO:0000250}.
FT   DISULFID   3591   3606       {ECO:0000250}.
FT   DISULFID   3610   3622       {ECO:0000250}.
FT   DISULFID   3617   3635       {ECO:0000250}.
FT   DISULFID   3629   3644       {ECO:0000250}.
FT   DISULFID   3658   3676       {ECO:0000250}.
FT   DISULFID   3670   3687       {ECO:0000250}.
FT   DISULFID   3692   3706       {ECO:0000250}.
FT   DISULFID   3700   3719       {ECO:0000250}.
FT   DISULFID   3713   3728       {ECO:0000250}.
FT   DISULFID   3738   3752       {ECO:0000250}.
FT   DISULFID   3747   3765       {ECO:0000250}.
FT   DISULFID   3759   3774       {ECO:0000250}.
FT   DISULFID   3783   3796       {ECO:0000250}.
FT   DISULFID   3790   3805       {ECO:0000250}.
FT   DISULFID   3807   3820       {ECO:0000250}.
FT   DISULFID   3826   3836       {ECO:0000250}.
FT   DISULFID   3832   3845       {ECO:0000250}.
FT   DISULFID   3847   3858       {ECO:0000250}.
FT   DISULFID   4150   4159       {ECO:0000250}.
FT   DISULFID   4155   4168       {ECO:0000250}.
FT   DISULFID   4170   4181       {ECO:0000250}.
FT   DISULFID   4199   4209       {ECO:0000250}.
FT   DISULFID   4203   4219       {ECO:0000250}.
FT   DISULFID   4221   4230       {ECO:0000250}.
FT   DISULFID   4235   4245       {ECO:0000250}.
FT   DISULFID   4239   4255       {ECO:0000250}.
FT   DISULFID   4257   4266       {ECO:0000250}.
FT   DISULFID   4271   4281       {ECO:0000250}.
FT   DISULFID   4275   4291       {ECO:0000250}.
FT   DISULFID   4293   4302       {ECO:0000250}.
FT   DISULFID   4307   4317       {ECO:0000250}.
FT   DISULFID   4311   4327       {ECO:0000250}.
FT   DISULFID   4329   4338       {ECO:0000250}.
FT   DISULFID   4343   4351       {ECO:0000250}.
FT   DISULFID   4346   4362       {ECO:0000250}.
FT   DISULFID   4364   4373       {ECO:0000250}.
FT   DISULFID   4376   4386       {ECO:0000250}.
FT   DISULFID   4380   4397       {ECO:0000250}.
FT   DISULFID   4399   4408       {ECO:0000250}.
FT   VAR_SEQ    2725   2729       SERQD -> N (in isoform 2).
FT                                {ECO:0000303|PubMed:7506255}.
FT                                /FTId=VSP_004312.
SQ   SEQUENCE   4543 AA;  507133 MW;  C8D5823BB868BAD5 CRC64;
     MGPLLALAGC LLALLAAPAA RALEAPKTCS PKQFACKDQI TCISKGWRCD GEKDCPDGSD
     ESPDICPQSK VSRCQPNEHN CLGTELCIHM SKLCNGLHDC FDGSDEGPHC REQLANCTAL
     GCQHHCVPTL SGPACYCNNS FQLAEDRRSC KDFDECTVYG TCSQTCTNTE GSYTCSCVEG
     YLLQPDNRSC KAKNEPVDRP PVLLIANSQN ILATYLSGAP VPNITPTSAK QTTAMDFNYI
     EDTVCWVHVG DSASQTILKC AKIPNLKGFV EERSINISLS LHQVEQMAID WLTGNFYFVD
     DIDDRIFVCN KNGLTCVTLL DLELYNPKGI ALDPAMGKVF FTDYGQIPKV ERCDMDGQNR
     TKLVDSKIVF PHGITLDLVS RLVYWADAYL DYIEVVDYEG KNRHTIIQGI LIEHLYGLTV
     FENYLYATNS DNANAQQKTS VIRVNRFNST EYQVVTRVDK GGALHIYHQR RQPTVRSHAC
     EPDQFGKPGG CSDICLLGNS HKSRTCRCRS GFSLGSDGKS CKKPEHELFL VYGKGRPGII
     RGMDMGAKVP DEHMIPIENL MNPRALDFHA ETGFIYFADT TSYLIGRQKI DGTERETILK
     DGIHNVEGIA VDWMGNNLYW TDDGPKKTIS VARLEKAAQT RKTLIEGKMT HPRAIVVDPL
     NGWMYWTDWE EDPKDSKRGK IERAWMDGSN RNVFITSKTV LWPNGLSLDI PAKILYWVDA
     FYDRIEMVYL NGTERKIVYE GPELNHAFGL CHYSSFLFWT EYRSGSIYRL DQSSKAVSLL
     RNERPPIFEI RMYDAQQQQV GSNKCRVNNG GCSSLCLATP RGRQCACAED QILGADSVTC
     EANPSYIPPP QCQPGEFACK NNRCIQERWK CDGDNDCLDN SDEAPELCHQ HTCPSDRFKC
     KNNRCIPNRW LCDGDNDCGN NEDESNSTCS ARTCSPNQFS CASGRCIPIS WTCDLDDDCG
     DRSDESASCA YPTCFPLTQF TCNNGRCINI NWRCDNDNDC GDNSDEAGCS HSCSSNQFKC
     NSGRCIPVHW TCDGDNDCGD YSDETHANCT NQATRPPGGC HTDEFQCRLD GLCIPMRWRC
     DGDTDCMDSS DEKNCEGVTH VCDPNVKFGC KDSARCISKA WVCDGDSDCE DNSDEENCES
     LVCKPPSHTC ANNTSICLPP EKLCDGSDDC GDGSDEGELC DQCSLNNGGC SHNCTVAPGE
     GIVCSCPLGM ELGADNKTCQ IQSYCAKHLK CSQKCEQDKY NVKCSCYEGW MLEPDGESCR
     SLDPFKPFII FSNRHEIRRI DLHRGDYSVL VPGLRNTIAL DFHLNQSSLY WTDVVEDKIY
     RGKLLENGAL TSFEVVIQYG LATPEGLAVD WIAGNIYWVE SNLDQIEVAK LDGTMRTTLL
     AGDIEHPRAI ALDPRYGILF WTDWDASLPR IEAASMSGAG RRTIHKETGS GGWPNGLTVD
     YLEKRILWID ARSDAIYSAL YDGTGHIEVL RGHEYLSHPF AVTLYGGEVY WTDWRTNTLA
     KANKWTGHNV TVVQRTNTQP FDLQVYHPSR QPLAPNPCEA NGGKGPCSHL CLINYNRTLS
     CACPHLMKLD KDNTTCYEFK KFLLYARQME IRGVDIDNPY YNYIISFTVP DIDNVTVVDY
     DAVEQRIYWS DVRTQTIKRA FINGTGVETV VSADLPNAHG LSVDWVSRNL FWTSYDTNKK
     QINVARLDGS FKNAVIQGLD KPHCLVVHPL HGKLYWTDGD NISVANMDGS NRTLLFTNQR
     GPVGLAIDYP ESKLYWISSG NGTINRCNLD GSDLEVIVAV KSQLSKATAL AIMGDKLWWA
     DQASERMGTC NKKDGTEVTV LRNSTTLVML MKVYDESIQQ AGSNPCSVNN GDCSQLCLPT
     SETSRSCMCT AGYSLKSGQQ SCEGVGSFLL YSVHEGIRGI PLDPNDKSDA LVPVSGTSLA
     VGIDFHAEND TIYWVDMGLS TISRAKRDQT WREDVVTNGI GRVEGIAVDW IAGNIYWTDQ
     GFDVIEVARL NGSFRYVVIS QGLDKPRAIT VHPEKGYLFW TEWGQYPRIE RSRLDGTERM
     VLVNVSISWP NGISVDYEDG KLYWCDARTD KIERIDLETG ENREVVLSSD NMDMFSVSVF
     EDYIYWSDRT HANGSIKRGS KDNATESVSL RTGIGVQLKD IKVFNRARQK GTNVCAQNNG
     GCQQLCLFRG GGRRTCACAH GMLSEDGVSC RDYDGYLLYS ERTILKSIHL SDENNLNAPI
     KPFEDAEHMK NVIALAFDYR YGTKGSNRIF YSDIHFGNIQ QINDDGTGRR TIVENVGSVE
     GLAYHRGWDT LYWTSYTTST ITRHTVDQSR LGAFERETVI TMSGDDHPRA FVLDECQNLM
     FWTNWNEQHP SIMRATLSGA NVLIIIDQDI RTPNGLAIDH RAEKIYFSDA TLDKIERCEY
     DGSHRHVILK SEPVHPFGLA VYGDYIFWTD WVRRAVQRAN KYVGTDMKLL RVDIPQQPMG
     IIAVANDTDS CELSPCRVNN GGCQDLCLLT PKGHVNCSCR GERVLQEDFT CKALNSTCNV
     HDEFECGNGD CIDFSRTCDG VVHCKDKSDE KQSYCSSRKC KKGFLHCMNG RCVASRFWCN
     GVDDCGDNSD EVPCNKTSCA ATEFRCRDGS CIGNSSRCNQ FIDCEDASDE MNCTATDCSS
     YFKLGVKGTT FQKCEHTSLC YAPSWVCDGA NDCGDYSDER NCPGGRKPKC PANYFACPSG
     RCIPMTWTCD KEDDCENGED ETHCSERQDK FCYPVQFECN NHRCISKLWV CDGADDCGDG
     SDEDSRCRLT TCSTGSFQCP GTYVCVPERW LCDGDKDCAD GADETLAAGC LYNNTCDERE
     FMCGNRQCIP KHFVCDHDDD CGDGSDESPE CEYPTCGPHE FRCANGRCLS NSQWECDGEF
     DCHDHSDEAP KNPRCSSPES KCNDSFFMCK NGKCIPEALL CDNNNDCADG SDELNCFINE
     CLNKKLSGCS QECEDLKIGY KCRCRPGFRL KDDGKTCIDI DECSTTYPCS QKCINTLGSY
     KCLCIEGYKL KPDNPTSCKA VTDEEPFLIF ANRYYLRKLN LDGSNYTLLK QGLNNAVALD
     FDYREQMIYW TDVTTQGSMI RRMHINGSNV QVLHRTGLSN PDGLAVDWVG GNLYWCDKGR
     DTIEVSKLNG AYRTVLVNSG LREPRALVVD VQNGYLYWTD WGDHSLIGKI GMDGTNRSVI
     VDTKITWPNG LTLDYINSRI YWADAREDYI EFASLDGSNR HTVLSQDIPH IFALTLFEDY
     IYWTDWETKS INRAHKTTGA NKTLLISTLH RPMDIHIYHP YRQPDVPNHP CKTNNAGCSN
     LCLLSPGGGH KCACPTNFYL GSDGKTCVSN CTASQFVCKN DKCIPFWWKC DTEDDCGDRS
     DEPEDCPEFK CRPGQFQCST GICTNPAFIC DGDNDCQDNS DEANCDIHVC LPSQFKCTNT
     NRCIPGIFRC NGQDNCGDGE DEKDCPEVTC APNQFQCAIT KRCIPRVWVC DRDNDCVDGS
     DEPANCTQMT CGVDEFRCKD SGRCIPARWK CDGEDDCGDG SDEPKEECDE RTCEPYQFRC
     KNNRCVPGRW QCDYDNDCGD NSDEESCTPR PCSESEFSCA NGRCIAGRWK CDGDHDCADG
     SDEKDCIPRC EFDQYQCKNG HCIPMRWRCD ADADCMDGTD EEDCGTGVRT CPLDEFQCNN
     TLRKPLAWKC DGEDDCGDNS DENPEECLKF QCPPNRPFRC KNDRVCLWIG RQCDGIDNCG
     DNTDEKDCES PTAKPKSCSQ DKNEFLCENK KCISANLRCN FFDDCGDGSD EKSCSHEHKS
     YDCMTNTTMC GDEAQCIQAQ SSTYCTCRRG FQKVPDKNSC QDVNECLRFG TCSQLCNNTK
     GSHVCSCAKN FMKTDNMCKA EGSEHQILYI ADDNKIRSMY PFNPNSAYEP AFQGDENVRI
     DAMDIYVKGN KIYWTNWHTG RISYCELPAS SAASTASNRN RRQIDGGVTH LNISGLKMPR
     GIAVDWVAGN IYWTDSGRDV IEVAQMKGEN RKTLISGMID EPHAIVVDPL RGTMYWSDWG
     NHPKIETAAM DGTLRETLVQ DNIQWPTGLA VDYHNERLYW ADAKLSVIGS IRLNGTDPVV
     AIDNKKGLSH PFSIDIFEDY IYGVTYINNR IFKIHKFGHK SVTNLTSGLN HATDVVLYHQ
     YKQPEVTNPC DRKKCEWLCL LSPSGPVCTC PNGKRLDNGT CVLIPSPTAS AVVPTTDTCD
     LVCLNGGSCF LNARKQAKCR CQPRYNGERC QINQCSDYCQ NGGLCTASPS GMPTCRCPTG
     FTGSRCDQQV CTNYCHNNGS CTVNQGNQPN CRCPPTFIGD RCQYQQCFNY CENNGVCQMS
     RDGVKQCRCP PQFEGAQCQD NKCSRCQEGK CNINRQSGDV SCICPDGKIA PSCLTCDSYC
     LNGGTCSISD KTQLPECLCP LEVTGMRCEE FIVGEQQSGR TASIVIPILL LLLLLAVVAF
     AWYKWRIKGA KGFQHQRMTN GAMNVEIGNP TYKMYEGEPD DDVGELLDAD FALDPDKPTN
     FTNPVYATLY MGAHSSRNSL ASTDEKRELL ARGADDDLTD PLA
//
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