ID SUGA_MYCTO Reviewed; 307 AA.
AC P9WG02; F2GFS6; L0T699; O50452; Q7D8J8;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Trehalose transport system permease protein SugA;
GN Name=sugA; OrderedLocusNames=MT1274;
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- FUNCTION: Part of the ABC transporter complex LpqY-SugA-SugB-SugC,
CC which is highly specific for uptake of trehalose. Involved in the
CC recycling of extracellular trehalose released from trehalose-containing
CC molecules synthesized by M.tuberculosis. Trehalose uptake is essential
CC for virulence. Probably responsible for the translocation of the
CC substrate across the membrane (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (SugC),
CC two transmembrane proteins (Suga and SugB) and a solute-binding protein
CC (LpqY). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. {ECO:0000305}.
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DR EMBL; AE000516; AAK45532.1; -; Genomic_DNA.
DR PIR; C70952; C70952.
DR RefSeq; WP_003406295.1; NZ_KK341227.1.
DR AlphaFoldDB; P9WG02; -.
DR SMR; P9WG02; -.
DR GeneID; 45425206; -.
DR KEGG; mtc:MT1274; -.
DR PATRIC; fig|83331.31.peg.1377; -.
DR HOGENOM; CLU_016047_0_3_11; -.
DR Proteomes; UP000001020; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; MetI-like; 1.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR PANTHER; PTHR43759:SF1; GLUCOSE IMPORT SYSTEM PERMEASE PROTEIN GLCT; 1.
DR PANTHER; PTHR43759; TREHALOSE TRANSPORT SYSTEM PERMEASE PROTEIN SUGA; 1.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; MetI-like; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..307
FT /note="Trehalose transport system permease protein SugA"
FT /id="PRO_0000428447"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 85..291
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 307 AA; 33051 MW; 8B88E852E40F622D CRC64;
MTSVEQRTAT AVFSRTGSRM AERRLAFMLV APAAMLMVAV TAYPIGYALW LSLQRNNLAT
PNDTAFIGLG NYHTILIDRY WWTALAVTLA ITAVSVTIEF VLGLALALVM HRTLIGKGLV
RTAVLIPYGI VTVVASYSWY YAWTPGTGYL ANLLPYDSAP LTQQIPSLGI VVIAEVWKTT
PFMSLLLLAG LALVPEDLLR AAQVDGASAW RRLTKVILPM IKPAIVVALL FRTLDAFRIF
DNIYVLTGGS NNTGSVSILG YDNLFKGFNV GLGSAISVLI FGCVAVIAFI FIKLFGAAAP
GGEPSGR
//
