ID MODB_MYCTO Reviewed; 264 AA.
AC P9WG12; L0TAT4; O08061; P0A624; P95156;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Molybdenum transport system permease protein ModB;
GN Name=modB; OrderedLocusNames=MT1906;
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- FUNCTION: Part of the binding-protein-dependent transport system
CC ModABCD for molybdenum; probably responsible for the translocation of
CC the substrate across the membrane. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. CysTW subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK46177.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE000516; AAK46177.1; ALT_INIT; Genomic_DNA.
DR PIR; B70666; B70666.
DR RefSeq; WP_003409329.1; NZ_KK341227.1.
DR AlphaFoldDB; P9WG12; -.
DR SMR; P9WG12; -.
DR GeneID; 45425831; -.
DR KEGG; mtc:MT1906; -.
DR PATRIC; fig|83331.31.peg.2050; -.
DR HOGENOM; CLU_016047_14_1_11; -.
DR Proteomes; UP000001020; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015098; F:molybdate ion transmembrane transporter activity; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; MetI-like; 1.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR InterPro; IPR011867; ModB_ABC.
DR InterPro; IPR006469; NifC_ABC_porter.
DR NCBIfam; TIGR01581; Mo_ABC_porter; 1.
DR NCBIfam; TIGR02141; modB_ABC; 1.
DR PANTHER; PTHR30183; MOLYBDENUM TRANSPORT SYSTEM PERMEASE PROTEIN MODB; 1.
DR PANTHER; PTHR30183:SF3; MOLYBDENUM TRANSPORT SYSTEM PERMEASE PROTEIN MODB; 1.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; MetI-like; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Molybdenum; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..264
FT /note="Molybdenum transport system permease protein ModB"
FT /id="PRO_0000428442"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 51..253
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 264 AA; 27676 MW; D20EC44EB28DD526 CRC64;
MHPPTDLPRW VYLPAIAGIV FVAMPLVAIA IRVDWPRFWA LITTPSSQTA LLLSVKTAAA
STVLCVLLGV PMALVLARSR GRLVRSLRPL ILLPLVLPPV VGGIALLYAF GRLGLIGRYL
EAAGISIAFS TAAVVLAQTF VSLPYLVISL EGAARTAGAD YEVVAATLGA RPGTVWWRVT
LPLLLPGVVS GSVLAFARSL GEFGATLTFA GSRQGVTRTL PLEIYLQRVT DPDAAVALSL
LLVVVAALVV LGVGARTPIG TDTR
//
