ID PALF_YARLI Reviewed; 881 AA.
AC Q9UVF5; Q6C8J3;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=pH-response regulator protein palF/RIM8;
GN Name=RIM8; Synonyms=PAL3; OrderedLocusNames=YALI0D19162g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=ATCC 20460 / W29 / CBS 7504 / IFP29;
RX PubMed=10821185; DOI=10.1007/s004380051195;
RA Treton B., Blanchin-Roland S., Lambert M., Lepingle A., Gaillardin C.;
RT "Ambient pH signalling in ascomycetous yeasts involves homologues of the
RT Aspergillus nidulans genes palF and palH.";
RL Mol. Gen. Genet. 263:505-513(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
RN [3]
RP FUNCTION.
RX PubMed=11861549; DOI=10.1093/genetics/160.2.417;
RA Gonzalez-Lopez C.I., Szabo R., Blanchin-Roland S., Gaillardin C.;
RT "Genetic control of extracellular protease synthesis in the yeast Yarrowia
RT lipolytica.";
RL Genetics 160:417-427(2002).
CC -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC factor RIM101 in response to alkaline ambient pH.
CC {ECO:0000269|PubMed:10821185, ECO:0000269|PubMed:11861549}.
CC -!- SIMILARITY: Belongs to the arrestin family. PalF/RIM8 subfamily.
CC {ECO:0000305}.
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DR EMBL; AJ133772; CAB59340.1; -; Genomic_DNA.
DR EMBL; CR382130; CAG81211.1; -; Genomic_DNA.
DR RefSeq; XP_503019.1; XM_503019.1.
DR AlphaFoldDB; Q9UVF5; -.
DR STRING; 284591.Q9UVF5; -.
DR EnsemblFungi; CAG81211; CAG81211; YALI0_D19162g.
DR GeneID; 2910312; -.
DR KEGG; yli:YALI0D19162g; -.
DR VEuPathDB; FungiDB:YALI0_D19162g; -.
DR HOGENOM; CLU_326837_0_0_1; -.
DR InParanoid; Q9UVF5; -.
DR OrthoDB; 1944514at2759; -.
DR Proteomes; UP000001300; Chromosome D.
DR GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 2.60.40.640; -; 3.
DR InterPro; IPR014752; Arrestin-like_C.
DR InterPro; IPR011021; Arrestin-like_N.
DR InterPro; IPR011022; Arrestin_C-like.
DR PANTHER; PTHR11188; ARRESTIN DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11188:SF161; PH-RESPONSE REGULATOR PROTEIN PALF_RIM8; 1.
DR Pfam; PF02752; Arrestin_C; 1.
DR Pfam; PF00339; Arrestin_N; 1.
DR SMART; SM01017; Arrestin_C; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..881
FT /note="pH-response regulator protein palF/RIM8"
FT /id="PRO_0000058193"
FT REGION 90..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 779..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 785..820
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..881
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 881 AA; 93141 MW; BB680C5D19B304F8 CRC64;
MKSAFNKLRP NFWSRLTPSS DGDYFFVELE DAHRTWHPGD TVHGNVILVL YKPQRISSVD
LSFAGNVVVK SALVKGKGSR SVLFEQKLRL HGTPTAGSNS NTTPSSGNHN SHVSNSATNS
NRNSGSHMST RTSNRNSNSH VASNTPSMST SPTSTSSGVA ATADTTTTMD TNTSQASSTA
PDTLNPSSST ELSRTATRQS SDGSIWRSVG SSTPGAASGG VADMMMNSVT TEPVLSSRMS
MHTTNSHLSQ MSRESHVTTA SRESHMSRES NTSTSSTSEE LEIGEHRFAF ILEIPQKGLF
NSLEFERGSI SYVITAVAKR HGPLPALHAK RVLQLVCPVD VARLPPPKPS TLSVEIQKRK
KQQGIITTTL EVGRGGYLRG ESFPVKITIQ HVKCVKCLRG LVVTLCRFSK VTCNDDEPQS
FRKDLSQTVS PLYTDPVTFS STVSTTLRIP PDVFPTTKGH GLVSFNYCVE VVIDLAGKWD
LEEDRTGFLH TDRLKRNKGV VSLWTEVIIG TDRRRYRSDS HATAHTNTNH VTNHVSQNHG
SPGHVNFGHV PSPSGSSNHG NGHGAYGVGH ASQSSSPGNH SNYSYHGNPN HGASHINNHV
TAGSSHTSGG LSEKQLMKLR EEALLPSEPA AISSPSLDAF PSAPEYAIGD EVAGSSAGPS
APSAPAHTIA GVVASAPLTP SDKHENELLR LQGLSSDPYA DEDHVPQYKE KEKAPEEVVA
MQLNELASVP PIEGEIEEVG NSANAPSAPV MNGHEGGFFD APSEFSESSA PPVVHGHVHG
HVHGHSHSST GTIVSGDASA SAPAPTSIRS VSTAPSDTPT APPVITHGFT GPVGPGVVDP
GTSGTASTTV DSLNSEISSG TPASTLPDTN KSLSDSDDIY S
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