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Database: UniProt
Entry: PDC2_ORYSI
LinkDB: PDC2_ORYSI
Original site: PDC2_ORYSI 
ID   PDC2_ORYSI              Reviewed;         606 AA.
AC   A2XFI3; P51848;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   03-MAY-2023, entry version 83.
DE   RecName: Full=Pyruvate decarboxylase 2;
DE            Short=PDC;
DE            EC=4.1.1.1;
GN   Name=PDC2; ORFNames=OsI_010826;
OS   Oryza sativa subsp. indica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39946;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=cv. IR54; TISSUE=Callus;
RA   Huq M.E., Hossain M.A., Hodges T.K.;
RT   "Cloning and sequencing of a cDNA encoding pyruvate decarboxylase 2 gene
RT   from rice.";
RL   (er) Plant Gene Register PGR95-072(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. 93-11;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2-oxocarboxylate + H(+) = an aldehyde + CO2;
CC         Xref=Rhea:RHEA:11628, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:17478, ChEBI:CHEBI:35179; EC=4.1.1.1;
CC   -!- COFACTOR:
CC       Name=a metal cation; Xref=ChEBI:CHEBI:25213;
CC       Note=Binds 1 metal ion per subunit.;
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC       Note=Binds 1 thiamine pyrophosphate per subunit.;
CC   -!- SUBUNIT: Homotetramer. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA90948.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=AAA90948.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
CC       Sequence=AAB40530.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=AAB40530.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
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DR   EMBL; U27350; AAA90948.1; ALT_SEQ; mRNA.
DR   EMBL; U38199; AAB40530.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CM000128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A2XFI3; -.
DR   SMR; A2XFI3; -.
DR   STRING; 39946.A2XFI3; -.
DR   EnsemblPlants; BGIOSGA010938-TA; BGIOSGA010938-PA; BGIOSGA010938.
DR   Gramene; BGIOSGA010938-TA; BGIOSGA010938-PA; BGIOSGA010938.
DR   HOGENOM; CLU_013748_0_2_1; -.
DR   OMA; EQRYNDI; -.
DR   BRENDA; 4.1.1.1; 4460.
DR   SABIO-RK; A2XFI3; -.
DR   Proteomes; UP000007015; Chromosome 3.
DR   ExpressionAtlas; A2XFI3; differential.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0004737; F:pyruvate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd02005; TPP_PDC_IPDC; 1.
DR   CDD; cd07038; TPP_PYR_PDC_IPDC_like; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR012110; PDC/IPDC-like.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   InterPro; IPR047214; TPP_PDC_IPDC.
DR   InterPro; IPR047213; TPP_PYR_PDC_IPDC-like.
DR   PANTHER; PTHR43452; PYRUVATE DECARBOXYLASE; 1.
DR   PANTHER; PTHR43452:SF6; PYRUVATE DECARBOXYLASE C186.09-RELATED; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   PIRSF; PIRSF036565; Pyruvt_ip_decrb; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   2: Evidence at transcript level;
KW   Decarboxylase; Lyase; Magnesium; Metal-binding; Reference proteome;
KW   Thiamine pyrophosphate.
FT   CHAIN           1..606
FT                   /note="Pyruvate decarboxylase 2"
FT                   /id="PRO_0000303668"
FT   REGION          433..515
FT                   /note="Thiamine pyrophosphate binding"
FT   BINDING         68
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         155
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         483
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         510
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         512
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         516
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   606 AA;  64847 MW;  A43F1E7DBB6B46B6 CRC64;
     METHIGSVDG AAAAADNGAV GCPASAVGCP MTSARPAPVS AGEASLGRHL ARRLVQVGVS
     DVFAVPGDFN LTLLDHLIAE PGLRLVGCCN ELNAGYAADG YARARGVGAC AVTFTVGGLS
     VLNAIAGAYS ENLPVICIAG GPNSNDYGTN RILHHTIGLP DFSQELRCFQ TVTCHQAVVT
     NLEDAHEQID TAIATALRES KPVYLSISCN LPGLPHPTFS RDPVPFFLAP RLSNKMGLEA
     AVEATVEFLN KAVKPVLVGG PKLRVAKAGK AFVDLVDASG YAYAVMPSAK GLVPETHPHF
     IGTYWGAVST AFCAEIVESA DAYLFAGPIF NDYSSVGYSF LLKKDKAIIV QPERVIVGNG
     PAFGCVMMKE FLSELAKRVN KNTTAYENYK RIFVPEGQPL ESEPNEPLRV NVLFKHVQKM
     LNSDSAVIAE TGDSWFNCQK LKLPEGCGYE FQMQYGSIGW SVGALLGYAQ GAKDKRVIAC
     IGDGSFQVTA QDVSTMIRCA QNSIIFLINN GGYTIEVEIH DGPYNVIKNW NYTGLVDAIH
     NGEGKCWTSK VKCEEELTEA IGMALGEKKD CLCFIEVIAH KDDTSKELLE WGSRVSAANS
     RPPNPQ
//
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