ID PDXD1_DANRE Reviewed; 751 AA.
AC Q66HY8;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=Pyridoxal-dependent decarboxylase domain-containing protein 1;
DE EC=4.1.1.-;
GN Name=pdxdc1; ORFNames=zgc:92179;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000250};
CC -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC {ECO:0000305}.
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DR EMBL; BC081619; AAH81619.1; -; mRNA.
DR RefSeq; NP_001004552.2; NM_001004552.1.
DR AlphaFoldDB; Q66HY8; -.
DR SMR; Q66HY8; -.
DR STRING; 7955.ENSDARP00000136697; -.
DR PaxDb; 7955-ENSDARP00000118338; -.
DR GeneID; 447813; -.
DR KEGG; dre:447813; -.
DR AGR; ZFIN:ZDB-GENE-040912-16; -.
DR CTD; 23042; -.
DR ZFIN; ZDB-GENE-040912-16; pdxdc1.
DR eggNOG; KOG0630; Eukaryota.
DR InParanoid; Q66HY8; -.
DR PhylomeDB; Q66HY8; -.
DR PRO; PR:Q66HY8; -.
DR Proteomes; UP000000437; Chromosome 3.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016831; F:carboxy-lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR PANTHER; PTHR42735; -; 1.
DR PANTHER; PTHR42735:SF1; PYRIDOXAL-DEPENDENT DECARBOXYLASE DOMAIN-CONTAINING PROTEIN 1-RELATED; 1.
DR Pfam; PF00282; Pyridoxal_deC; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 2: Evidence at transcript level;
KW Decarboxylase; Lyase; Pyridoxal phosphate; Reference proteome.
FT CHAIN 1..751
FT /note="Pyridoxal-dependent decarboxylase domain-containing
FT protein 1"
FT /id="PRO_0000297680"
FT REGION 659..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..730
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 751 AA; 83141 MW; A5E123C385AA4A86 CRC64;
MGNHLSDAMK ILESGKLETE QGQEGRKMSW KEIPGPLQGD GQDVVSILQL VQNLMHGDDE
EQGHRMQFVG EQGHMALLGH SLAAYISVLE RERLRKLTTR ILSDTTLWLC RLFRYENGSA
YFHEDDREGL LKVCRLVMNT HYEDFTTEGF TALSSKHPVI YQSAACRPGL GQHLCSQLGL
PLSCLCVVPC NTMFGSLHQM DVALLDKLVK DDRDSGKLPL LLIANAGTPG AGHTDKLSRL
KELCVQYNMW LHVEGVNLAT LVLGQVSSTV TAATKCDSMT LTPGPWLGLP AVPAVTLYRH
EDPALSLAAG LTSSQPVEKL RALPLWLSLQ YLGHDGIVER IKHASQLSQQ LLEHLKTLAS
IKTSVEDELN SPVVVFRFSH ENSAPSSGGS VEGSYAGERD ILDAFNRWLG DQLAEQVPLS
GVDVVELEDE GTCVRFSPLM TAAALGTQEN DVAALVEKLA EMIPLLCCTL RLRQDFRDEV
LQQASLSYIE DLNWPGLGVV RFEPRTTDLD EDKRQDRVEK INSDLLKKLM ELDTDLNFSG
GPEFSEEKNC IFIGIATEDL DVAELVETIM SLGRDIEESG KLFENMTEVV RKGIQEAELQ
LQKANEEKLM EEGVLRQIPL VSSVLNWFSP VQASVKGRTF NLAEGCLDST EPVYSIKAQM
RKEDSPDSPK ANTRRFPGQK LFRRPGAGSD SISETSSVSQ LEESFRETLH SQAADEAEVP
QERPAHILEE TAIADQRVPE GQEAESVETI R
//
