ID PRW1_SCHPO Reviewed; 431 AA.
AC O14021;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 24-JAN-2024, entry version 168.
DE RecName: Full=RbAp48-related WD40 repeat-containing protein prw1;
GN Name=prw1; ORFNames=SPAC29A4.18;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP PROTEIN SEQUENCE OF 12-24; 36-47 AND 318-349, IDENTIFICATION, FUNCTION,
RP SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=12773392; DOI=10.1093/emboj/cdg248;
RA Nakayama J., Xiao G., Noma K., Malikzay A., Bjerling P., Ekwall K.,
RA Kobayashi R., Grewal S.I.S.;
RT "Alp13, an MRG family protein, is a component of fission yeast Clr6 histone
RT deacetylase required for genomic integrity.";
RL EMBO J. 22:2776-2787(2003).
CC -!- FUNCTION: Has a role in chromatin assembly and chromosome segregation.
CC Involved in the deacetylation of histones.
CC {ECO:0000269|PubMed:12773392}.
CC -!- SUBUNIT: Heterotetramer of alp13, clr6, prw1 and pst2.
CC {ECO:0000269|PubMed:12773392}.
CC -!- INTERACTION:
CC O14021; O13919: pst2; NbExp=3; IntAct=EBI-904698, EBI-904686;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12773392}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB10144.1; -; Genomic_DNA.
DR PIR; T38471; T38471.
DR RefSeq; NP_594864.1; NM_001020293.2.
DR PDB; 8I02; EM; 2.90 A; C=1-431.
DR PDB; 8I03; EM; 3.20 A; J/K=1-431.
DR PDBsum; 8I02; -.
DR PDBsum; 8I03; -.
DR AlphaFoldDB; O14021; -.
DR SMR; O14021; -.
DR BioGRID; 278295; 405.
DR DIP; DIP-29342N; -.
DR IntAct; O14021; 8.
DR STRING; 284812.O14021; -.
DR iPTMnet; O14021; -.
DR MaxQB; O14021; -.
DR PaxDb; 4896-SPAC29A4-18-1; -.
DR EnsemblFungi; SPAC29A4.18.1; SPAC29A4.18.1:pep; SPAC29A4.18.
DR GeneID; 2541804; -.
DR KEGG; spo:SPAC29A4.18; -.
DR PomBase; SPAC29A4.18; prw1.
DR VEuPathDB; FungiDB:SPAC29A4.18; -.
DR eggNOG; KOG0264; Eukaryota.
DR HOGENOM; CLU_020445_3_1_1; -.
DR InParanoid; O14021; -.
DR OMA; RALEWPC; -.
DR PhylomeDB; O14021; -.
DR Reactome; R-SPO-3214815; HDACs deacetylate histones.
DR PRO; PR:O14021; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:1990483; C:Clr6 histone deacetylase complex I''; IPI:PomBase.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0033698; C:Rpd3L complex; IDA:PomBase.
DR GO; GO:0070210; C:Rpd3L-Expanded complex; IDA:PomBase.
DR GO; GO:0032221; C:Rpd3S complex; IDA:PomBase.
DR GO; GO:0000510; F:H3-H4 histone complex chaperone activity; TAS:PomBase.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0006338; P:chromatin remodeling; IMP:PomBase.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR GO; GO:0045815; P:transcription initiation-coupled chromatin remodeling; IC:PomBase.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR022052; Histone-bd_RBBP4_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22850:SF219; RBAP48-RELATED WD40 REPEAT-CONTAINING PROTEIN PRW1; 1.
DR PANTHER; PTHR22850; WD40 REPEAT FAMILY; 1.
DR Pfam; PF12265; CAF1C_H4-bd; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Chromatin regulator; Direct protein sequencing; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW WD repeat.
FT CHAIN 1..431
FT /note="RbAp48-related WD40 repeat-containing protein prw1"
FT /id="PRO_0000051170"
FT REPEAT 127..159
FT /note="WD 1"
FT REPEAT 182..213
FT /note="WD 2"
FT REPEAT 232..263
FT /note="WD 3"
FT REPEAT 279..310
FT /note="WD 4"
FT REPEAT 323..354
FT /note="WD 5"
FT REPEAT 380..411
FT /note="WD 6"
SQ SEQUENCE 431 AA; 48476 MW; 4AFF1BDA12C4DBC2 CRC64;
MAVSAVPHPS KQAQASEEGI NQEKCINEEY KIWKKNSPFL YDLIITRALE WPCMSLQWYP
EQQIFAEHGY TEQKMFLGVR ADVGKYLLAV ASIQLPYLNQ TVPPTTMEGA SAGDESSLRV
NISNLYSHPE SVCSAKLMPQ DDSCVATVGN YHNDVLVFDK ESFESYSSAS ESPLKPKYRL
TKHTQPCTSV CWNFLSKGTL VSGSQDATLS CWDLNAYNES DSASVLKVHI SSHEKQVSDV
RFHYKHQDLL ASVSYDQYLH VHDIRRPDAS TKPARSVHAH SGPIHSVAFN PHNDFILATC
STDKTIALWD LRNLNQRLHT LEGHEDIVTK ISFSPHEEPI LASTSADRRT LVWDLSRIGE
DQPAEEAQDG PPELLFMHGG HTSCTIDMDW CPNYNWTMAT AAEDNILQIW TPSRSIWGNE
QLEEDATAYL S
//
