ID PSPN_MOUSE Reviewed; 156 AA.
AC O70300;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 08-NOV-2023, entry version 119.
DE RecName: Full=Persephin;
DE Short=PSP;
DE Flags: Precursor;
GN Name=Pspn;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=129/SvJ;
RX PubMed=9491986; DOI=10.1016/s0896-6273(00)80453-5;
RA Milbrandt J., de Sauvage F.J., Fahrner T.J., Baloh R.H., Leitner M.L.,
RA Tansey M.G., Lampe P.A., Heuckeroth R.O., Kotzbauer P.T., Simburger K.S.,
RA Golden J.P., Davies J.A., Vejsada R., Kato A.C., Hynes M., Sherman D.,
RA Nishimura M., Wang L.-C., Vandlen R., Moffat B., Klein R.D., Poulsen K.,
RA Gray C., Garces A., Henderson C.E., Phillips H.S., Johnson E.M.;
RT "Persephin, a novel neurotrophic factor related to GDNF and neurturin.";
RL Neuron 20:245-253(1998).
CC -!- FUNCTION: Exhibits neurotrophic activity on mesencephalic dopaminergic
CC and motor neurons.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
CC {ECO:0000305}.
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DR EMBL; AF040960; AAC40057.1; -; mRNA.
DR CCDS; CCDS28922.1; -.
DR AlphaFoldDB; O70300; -.
DR SMR; O70300; -.
DR STRING; 10090.ENSMUSP00000002740; -.
DR PhosphoSitePlus; O70300; -.
DR PaxDb; 10090-ENSMUSP00000002740; -.
DR AGR; MGI:1201684; -.
DR MGI; MGI:1201684; Pspn.
DR eggNOG; ENOG502S9IE; Eukaryota.
DR InParanoid; O70300; -.
DR PhylomeDB; O70300; -.
DR Reactome; R-MMU-5673001; RAF/MAP kinase cascade.
DR Reactome; R-MMU-8853659; RET signaling.
DR PRO; PR:O70300; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; O70300; Protein.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0030116; F:glial cell-derived neurotrophic factor receptor binding; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:InterPro.
DR GO; GO:0005102; F:signaling receptor binding; TAS:MGI.
DR GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IDA:MGI.
DR CDD; cd19382; TGF_beta_Persephin; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR043401; GDNF_fam.
DR InterPro; IPR001839; TGF-b_C.
DR PANTHER; PTHR12173; GDNF SUBFAMILY OF TGF-BETA FAMILY; 1.
DR PANTHER; PTHR12173:SF8; PERSEPHIN; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..156
FT /note="Persephin"
FT /id="PRO_0000034015"
FT DISULFID 66..124
FT /evidence="ECO:0000250"
FT DISULFID 93..152
FT /evidence="ECO:0000250"
FT DISULFID 97..154
FT /evidence="ECO:0000250"
FT DISULFID 123
FT /note="Interchain"
FT /evidence="ECO:0000250"
SQ SEQUENCE 156 AA; 17031 MW; 7DC6DD98132E041B CRC64;
MAAGRLRILC LLLLSLHPSL GWVLDLQEAS VADKLSFGKM AETRGTWTPH QGNNHVRLPR
ALAGSCRLWS LTLPVAELGL GYASEEKVIF RYCAGSCPQE ARTQHSLVLA RLRGRGRAHG
RPCCQPTSYA DVTFLDDQHH WQQLPQLSAA ACGCGG
//
