ID PURR_STRR6 Reviewed; 275 AA.
AC P65833; Q97NP1;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE RecName: Full=Pur operon repressor;
GN Name=purR; OrderedLocusNames=spr1793;
OS Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=171101;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-255 / R6;
RX PubMed=11544234; DOI=10.1128/jb.183.19.5709-5717.2001;
RA Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S.,
RA DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J.,
RA Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M.,
RA McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B.,
RA Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y.,
RA Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R.,
RA Rosteck P.R. Jr., Skatrud P.L., Glass J.I.;
RT "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL J. Bacteriol. 183:5709-5717(2001).
CC -!- FUNCTION: Controls the transcription of the pur operon for purine
CC biosynthetic genes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC family. {ECO:0000305}.
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DR EMBL; AE007317; AAL00596.1; -; Genomic_DNA.
DR PIR; G98095; G98095.
DR RefSeq; NP_359385.1; NC_003098.1.
DR RefSeq; WP_001809310.1; NC_003098.1.
DR AlphaFoldDB; P65833; -.
DR SMR; P65833; -.
DR STRING; 171101.spr1793; -.
DR GeneID; 66807041; -.
DR KEGG; spr:spr1793; -.
DR PATRIC; fig|171101.6.peg.1935; -.
DR eggNOG; COG0503; Bacteria.
DR HOGENOM; CLU_088227_0_0_9; -.
DR Proteomes; UP000000586; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0045982; P:negative regulation of purine nucleobase metabolic process; IEA:InterPro.
DR CDD; cd06223; PRTases_typeI; 1.
DR Gene3D; 3.40.50.2020; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR InterPro; IPR015265; PuR_N.
DR InterPro; IPR010078; PurR_Bsub.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR01743; purR_Bsub; 1.
DR PANTHER; PTHR43864; HYPOXANTHINE/GUANINE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR43864:SF2; PUR OPERON REPRESSOR; 1.
DR Pfam; PF00156; Pribosyltran; 1.
DR Pfam; PF09182; PuR_N; 1.
DR SUPFAM; SSF53271; PRTase-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..275
FT /note="Pur operon repressor"
FT /id="PRO_0000139703"
SQ SEQUENCE 275 AA; 30227 MW; DC64763E4E03E5FC CRC64;
MKLRRSDRMV VISNYLINNP YKLTSLNTFA EKYESAKSSI SEDIVIIKRA FEEIEIGHIQ
TVTGAGGGVI FTPSISSQDA KEMVEDLRTK LSESDRILPG GYIYLSDLLS TPAILKNIGR
IIAKSFMDQK IDAVMTVATK GVPLANAVAN VLNVSFVIVR RDLKITEGST VSVNYVSGSS
GDRIEKMFLS KRSLKAGSRV LIVDDFLKGG GTVNGMISLL REFDSELAGV AVFADNAQEE
REKQFDYKSL LKVTNIDVKN QAIDVEVGNI FDEDK
//
