ID PXR1_YARLI Reviewed; 292 AA.
AC Q6C1L3;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 24-JAN-2024, entry version 73.
DE RecName: Full=Protein PXR1;
DE AltName: Full=PinX1-related protein 1;
GN Name=PXR1; OrderedLocusNames=YALI0F15235g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Involved in rRNA-processing at A0, A1 and A2 sites and
CC negatively regulates telomerase. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PINX1 family. {ECO:0000305}.
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DR EMBL; CR382132; CAG78258.1; -; Genomic_DNA.
DR RefSeq; XP_505449.1; XM_505449.1.
DR AlphaFoldDB; Q6C1L3; -.
DR STRING; 284591.Q6C1L3; -.
DR EnsemblFungi; CAG78258; CAG78258; YALI0_F15235g.
DR GeneID; 2908653; -.
DR KEGG; yli:YALI0F15235g; -.
DR VEuPathDB; FungiDB:YALI0_F15235g; -.
DR HOGENOM; CLU_052839_0_0_1; -.
DR InParanoid; Q6C1L3; -.
DR OMA; PCWDQSS; -.
DR OrthoDB; 5485851at2759; -.
DR Proteomes; UP000001300; Chromosome F.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR InterPro; IPR000467; G_patch_dom.
DR PANTHER; PTHR23149; G PATCH DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23149:SF31; PROTEIN PXR1; 1.
DR Pfam; PF01585; G-patch; 1.
DR SMART; SM00443; G_patch; 1.
DR PROSITE; PS50174; G_PATCH; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT CHAIN 1..292
FT /note="Protein PXR1"
FT /id="PRO_0000324898"
FT DOMAIN 25..74
FT /note="G-patch"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 292 AA; 33199 MW; BCC5E47090A8338E CRC64;
MGLAGVSKKI KYGKDPRNLG WSNNTERFGH KHMSKLGWKD GEGLGHEDRK AQSITQNIKI
VLKDDNVGLG AGLAKADKDE AFGLMDFQKL LGKLNGRAQE IEAEVERQQK DVLRGKFGMV
FVSGGLLQGT IEEFNKKRGS EAVEESDSDS EESESESDDD KKSRKSSKKE KKDKKSKKRK
ADDDSDEEEK KSKKSKKDKK EKKEKKEKKE KKEKKEKKEK KEKKDKKEKK DKKEKKDKKS
ESPTPHDGME KPSASSTSAL RGRMAGRAKF IRSKRMAVMD EKSLNEIFMV KN
//
