ID   Q001C9_GASAC            Unreviewed;       329 AA.
AC   Q001C9;
DT   14-NOV-2006, integrated into UniProtKB/TrEMBL.
DT   14-NOV-2006, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   SubName: Full=Ectodysplasin receptor {ECO:0000313|EMBL:ABJ15832.1};
DE   Flags: Fragment;
GN   Name=EDAR {ECO:0000313|EMBL:ABJ15832.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|EMBL:ABJ15832.1};
RN   [1] {ECO:0000313|EMBL:ABJ15832.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Knecht A.K., Hosemann K.E., Kingsley D.M.;
RT   "Evolutionary utilization of the EDA signaling pathway in threespine
RT   sticklebacks.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DQ985077; ABJ15832.1; -; mRNA.
DR   AlphaFoldDB; Q001C9; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:InterPro.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR047526; TNR19/27/EDAR.
DR   PANTHER; PTHR12120; TNFR-CYS DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR12120:SF9; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER EDAR; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ABJ15832.1};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          75..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        83..97
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ABJ15832.1"
SQ   SEQUENCE   329 AA;  35324 MW;  E38D1479D508F8E8 CRC64;
     LATALIIAMS TIFIMAIAIV LIIMFYILKA KPNSQACCSG QVVKAVEAQS NKQEEKKEIP
     DKVVIYSEKD EFDKLKAPPQ KTVKSENDAS SENEQLLSRS IDSDEEAASD KQGSADANNP
     GLCLVNLGNK PDLCLLSLGL LERDRSGNGG PAMSANNIHG ANHISSVTAI NNNNNNKTPG
     MLQSRRKKIL DLYGRACNVT EGLSPTELPF DCLEKASRML SSSYSSEAAV VKTWRHLAES
     FGLKRDEIGG MSDGLQLFER VSTAGYSIPD LLTRLVHIER LDAVESLCSD VLGSSETAAA
     AGRQGNSSFH SQLVCPSSCL SPSQRCASV
//