ID HAT7_ARATH Reviewed; 314 AA.
AC Q00466; Q0WNS2; Q9LXG6;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 4.
DT 24-JAN-2024, entry version 169.
DE RecName: Full=Homeobox-leucine zipper protein HAT7;
DE AltName: Full=HD-ZIP protein ATHB-3;
DE AltName: Full=Homeodomain transcription factor ATHB-3;
DE AltName: Full=Homeodomain-leucine zipper protein HAT7;
DE Short=HD-ZIP protein 7;
GN Name=HAT7; Synonyms=ATHB-3; OrderedLocusNames=At5g15150; ORFNames=F8M21_40;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=1349836; DOI=10.1007/bf00019223;
RA Mattsson J., Soederman E., Svenson M., Borkird C., Engstroem P.;
RT "A new homeobox-leucine zipper gene from Arabidopsis thaliana.";
RL Plant Mol. Biol. 18:1019-1022(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 19-314 (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=7915839; DOI=10.1073/pnas.91.18.8393;
RA Schena M., Davis R.W.;
RT "Structure of homeobox-leucine zipper genes suggests a model for the
RT evolution of gene families.";
RL Proc. Natl. Acad. Sci. U.S.A. 91:8393-8397(1994).
RN [6]
RP GENE FAMILY, AND TISSUE SPECIFICITY.
RX PubMed=16055682; DOI=10.1104/pp.105.063461;
RA Henriksson E., Olsson A.S.B., Johannesson H., Johansson H., Hanson J.,
RA Engstroem P., Soederman E.;
RT "Homeodomain leucine zipper class I genes in Arabidopsis. Expression
RT patterns and phylogenetic relationships.";
RL Plant Physiol. 139:509-518(2005).
CC -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q00466-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q00466-2; Sequence=VSP_013647, VSP_013648, VSP_013649;
CC -!- TISSUE SPECIFICITY: Expressed predominantly in flowers, and in the
CC cortex of the root and the stem. {ECO:0000269|PubMed:16055682}.
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to intron retention.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class I subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA56906.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAB89325.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; X62644; CAA44513.1; -; mRNA.
DR EMBL; AL353993; CAB89325.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED92122.1; -; Genomic_DNA.
DR EMBL; AK229364; BAF01227.1; -; mRNA.
DR EMBL; U09340; AAA56906.1; ALT_INIT; mRNA.
DR PIR; S20930; S20930.
DR PIR; T49950; T49950.
DR PIR; T52370; T52370.
DR RefSeq; NP_568309.2; NM_121519.3. [Q00466-1]
DR AlphaFoldDB; Q00466; -.
DR SMR; Q00466; -.
DR STRING; 3702.Q00466; -.
DR PaxDb; 3702-AT5G15150-1; -.
DR ProteomicsDB; 247162; -. [Q00466-1]
DR EnsemblPlants; AT5G15150.1; AT5G15150.1; AT5G15150. [Q00466-1]
DR GeneID; 831367; -.
DR Gramene; AT5G15150.1; AT5G15150.1; AT5G15150. [Q00466-1]
DR KEGG; ath:AT5G15150; -.
DR Araport; AT5G15150; -.
DR TAIR; AT5G15150; HB-3.
DR eggNOG; KOG0483; Eukaryota.
DR HOGENOM; CLU_060842_4_0_1; -.
DR InParanoid; Q00466; -.
DR OMA; FHNIDEQ; -.
DR OrthoDB; 679932at2759; -.
DR PhylomeDB; Q00466; -.
DR PRO; PR:Q00466; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q00466; baseline and differential.
DR Genevisible; Q00466; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; ISS:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR045224; HDZip_class_I_plant.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000047; HTH_motif.
DR InterPro; IPR003106; Leu_zip_homeo.
DR PANTHER; PTHR24326; HOMEOBOX-LEUCINE ZIPPER PROTEIN; 1.
DR PANTHER; PTHR24326:SF538; HOMEOBOX-LEUCINE ZIPPER PROTEIN HAT7; 1.
DR Pfam; PF02183; HALZ; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..314
FT /note="Homeobox-leucine zipper protein HAT7"
FT /id="PRO_0000048903"
FT DNA_BIND 112..171
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 77..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..207
FT /note="Leucine-zipper"
FT COMPBIAS 77..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..63
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:1349836"
FT /id="VSP_013647"
FT VAR_SEQ 204..214
FT /note="LVALKKHDRKE -> VYNIHTNSTNR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:1349836"
FT /id="VSP_013648"
FT VAR_SEQ 215..314
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:1349836"
FT /id="VSP_013649"
FT CONFLICT 78
FT /note="H -> L (in Ref. 1; CAA44513)"
FT /evidence="ECO:0000305"
FT CONFLICT 78
FT /note="H -> Y (in Ref. 5; AAA56906)"
FT /evidence="ECO:0000305"
FT CONFLICT 266
FT /note="T -> A (in Ref. 5; AAA56906)"
FT /evidence="ECO:0000305"
FT CONFLICT 273
FT /note="Q -> E (in Ref. 5; AAA56906)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 314 AA; 36282 MW; 8DAC95F6DCD11F8B CRC64;
MYMYEEERNN INNNQEGLRL EMAFPQHGFM FQQLHEDNAH HLPSPTSLPS CPPHLFYGGG
GNYMMNRSMS FTGVSDHHHL TQKSPTTTNN MNDQDQVGEE DNLSDDGSHM MLGEKKKRLN
LEQVRALEKS FELGNKLEPE RKMQLAKALG LQPRQIAIWF QNRRARWKTK QLERDYDSLK
KQFDVLKSDN DSLLAHNKKL HAELVALKKH DRKESAKIKR EFAEASWSNN GSTENNHNNN
SSDANHVSMI KDLFPSSIRS ATATTTSTHI DHQIVQDQDQ GFCNMFNGID ETTSASYWAW
PDQQQQHHNH HQFN
//
