ID Q00GE4_PARLI Unreviewed; 519 AA.
AC Q00GE4;
DT 14-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 14-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Alx1 {ECO:0000313|EMBL:ABG00197.1};
OS Paracentrotus lividus (Common sea urchin).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC Euechinoidea; Echinacea; Camarodonta; Echinidea; Echinidae; Paracentrotus.
OX NCBI_TaxID=7656 {ECO:0000313|EMBL:ABG00197.1};
RN [1] {ECO:0000313|EMBL:ABG00197.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=14973284; DOI=10.1242/dev.01000;
RA Rottinger E., Besnardeau L., Lepage T.;
RT "A Raf/MEK/ERK signaling pathway is required for development of the sea
RT urchin embryo micromere lineage through phosphorylation of the
RT transcription factor Ets.";
RL Development 131:1075-1087(2004).
RN [2] {ECO:0000313|EMBL:ABG00197.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17038519; DOI=10.1242/dev.02603;
RA Rottinger E., Croce J., Lhomond G., Besnardeau L., Gache C., Lepage T.;
RT "Nemo-like kinase (NLK) acts downstream of Notch/Delta signalling to
RT downregulate TCF during mesoderm induction in the sea urchin embryo.";
RL Development 133:4341-4353(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR EMBL; DQ536192; ABG00197.1; -; mRNA.
DR AlphaFoldDB; Q00GE4; -.
DR SMR; Q00GE4; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR PANTHER; PTHR24329:SF574; ARISTALESS-LIKE HOMEOBOX PROTEIN; 1.
DR PANTHER; PTHR24329; HOMEOBOX PROTEIN ARISTALESS; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}.
FT DOMAIN 198..258
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 496..509
FT /note="OAR"
FT /evidence="ECO:0000259|PROSITE:PS50803"
FT DNA_BIND 200..259
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 86..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 519 AA; 55781 MW; 705721B5B318990A CRC64;
MYRMIFNNAN GQMPEEIVSG LHQKLPYVGL GTSSDDMGPS QQHQQFLHHQ RAGMTGGLSA
MSAMAASHRG LSPYSTEHSI AGILGSRSRS LSGSPDPSQN KDMIPLTTPS TPNPAPLGPP
TGATTTTTTL KPTGDSPLTD RSMDTSTPGL LTGMSGGMHK AEQDSTNNNA GANGKGNDDV
KSPGDPKDDD KNDSDAKRKK RRNRTTFTSY QLEEMEKVFQ RTHYPDVYCR EQLALRCDLT
EARVQVWFQN RRAKWRKRER FQQFQNMRGL GPGSGYEMPI APRPDAYSQV NSPGFHVLGD
THQPPAPVEG AMLRICRNLQ NLRREFDSRK IGCHPSSSVG GTPGTSTNEP QDTTANHSSM
IHQSSPWATA NMASPLASSM SPVGQQPQMP GQNPINSCMA PQSNLPSFMG VPSQHMNAAG
GVMNPMTSMT SMTSMTSMPT SMPPPSSVSA PVSSPSSTNF MSSVGGLNAA ASAYNGQYTE
MHPSLDGVGG VDRRTNSIAA LRLRAKEHSS VMGMMNGYS
//
