ID PRSA_LACLS Reviewed; 299 AA.
AC Q02VE3; P14308;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 1.
DT 01-MAY-2013, entry version 46.
DE RecName: Full=Foldase protein PrsA;
DE EC=5.2.1.8;
DE AltName: Full=Protease maturation protein PrtM;
DE Flags: Precursor;
GN Name=prsA; Synonyms=prtM; OrderedLocusNames=LACR_C43;
OS Lactococcus lactis subsp. cremoris (strain SK11).
OG Plasmid pSK111, and Plasmid pLACR3.
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=272622;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], POSSIBLE SUBCELLULAR LOCATION, AND
RP ROLE IN PRTP PROTEASE SECRETION.
RC PLASMID=pSK111;
RX PubMed=2496115;
RA Vos P., van Asseldonk M., van Jeveren F., Siezen R., Simons G.,
RA de Vos W.M.;
RT "A maturation protein is essential for production of active forms of
RT Lactococcus lactis SK11 serine proteinase located in or secreted from
RT the cell envelope.";
RL J. Bacteriol. 171:2795-2802(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK11; PLASMID=pLACR3;
RX PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B.,
RA Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N.,
RA Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K.,
RA Goodstein D.M., Hawkins T., Plengvidhya V., Welker D., Hughes J.,
RA Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B.,
RA Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E.,
RA Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C.,
RA Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J.,
RA Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S.,
RA Weimer B.C., Mills D.A.;
RT "Comparative genomics of the lactic acid bacteria.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 294-299.
RC PLASMID=pSK111;
RX PubMed=2166472;
RA Haandrikman A.J., van Leeuwen C., Kok J., Vos P., de Vos W.M.,
RA Venema G.;
RT "Insertion elements on lactococcal proteinase plasmids.";
RL Appl. Environ. Microbiol. 56:1890-1896(1990).
CC -!- FUNCTION: This protein is essential for production of active forms
CC of the serine proteinase located in or secreted from the cell
CC envelope.
CC -!- CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline
CC (omega=0).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor (Potential).
CC -!- SIMILARITY: Belongs to the PrsA family.
CC -!- SIMILARITY: Contains 1 PpiC domain.
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DR EMBL; J04962; AAA03532.1; -; Unassigned_DNA.
DR EMBL; CP000428; ABJ74079.1; -; Genomic_DNA.
DR EMBL; M37395; AAA25209.1; -; Genomic_DNA.
DR PIR; A32314; A32313.
DR RefSeq; YP_796510.1; NC_008505.1.
DR ProteinModelPortal; Q02VE3; -.
DR STRING; 272622.LACR_C43; -.
DR EnsemblBacteria; ABJ74079; ABJ74079; LACR_C43.
DR GeneID; 4405838; -.
DR KEGG; llc:LACR_C43; -.
DR PATRIC; 22286544; VBILacLac38071_0072.
DR eggNOG; COG0760; -.
DR HOGENOM; HOG000014031; -.
DR KO; K07533; -.
DR OMA; MQRVISQ; -.
DR ProtClustDB; PRK04405; -.
DR BioCyc; LLAC272622:GJUG-2654-MONOMER; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:HAMAP.
DR GO; GO:0006457; P:protein folding; IEA:HAMAP.
DR GO; GO:0000413; P:protein peptidyl-prolyl isomerization; IEA:GOC.
DR HAMAP; MF_01145; Foldase_PrsA; 1; -.
DR InterPro; IPR023059; Foldase_PrsA.
DR InterPro; IPR000297; PPIase_PpiC.
DR InterPro; IPR023058; PPIase_PpiC_CS.
DR InterPro; IPR027304; Trigger_fact/SurA_dom.
DR Pfam; PF00639; Rotamase; 1.
DR SUPFAM; SSF109998; Trigger_fac_C_bac; 1.
DR PROSITE; PS01096; PPIC_PPIASE_1; 1.
DR PROSITE; PS50198; PPIC_PPIASE_2; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane; Complete proteome; Isomerase; Lipoprotein; Membrane;
KW Palmitate; Plasmid; Rotamase; Signal.
FT SIGNAL 1 23 Potential.
FT CHAIN 24 299 Foldase protein PrsA.
FT /FTId=PRO_0000272037.
FT DOMAIN 144 236 PpiC.
FT LIPID 24 24 N-palmitoyl cysteine (Potential).
FT LIPID 24 24 S-diacylglycerol cysteine (Potential).
SQ SEQUENCE 299 AA; 33167 MW; 3A7B775DE3324F5B CRC64;
MKKKMRLKVL LASTATALLL LSGCQSNQTD QTVATYSGGK VTESSFYKEL KQSPTTKTML
ANMLIYRALN HAYGKSVSTK TVNDAYDSYK QQYGENFDAF LSQNGFSRSS FKESLRTNFL
SEVALKKLKK VSESQLKAAW KTYQPKVTVQ HILTSDEDTA KQVISDLAAG KDFAMLAKTD
SIDTATKDNG GKISFELNNK TLDATFKDAA YKLKNGDYTQ TPVKVTDGYE VIKMINHPAK
GTFTSSKKAL TASVYAKWSR DSSIMQRVIS QVLKNQHVTI KDKDLADALD SYKKLATTN
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