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Database: UniProt
Entry: Q02VE3
LinkDB: Q02VE3
Original site: Q02VE3 
ID   PRSA_LACLS              Reviewed;         299 AA.
AC   Q02VE3; P14308;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-SEP-2014, entry version 52.
DE   RecName: Full=Foldase protein PrsA;
DE            EC=5.2.1.8;
DE   AltName: Full=Protease maturation protein PrtM;
DE   Flags: Precursor;
GN   Name=prsA; Synonyms=prtM; OrderedLocusNames=LACR_C43;
OS   Lactococcus lactis subsp. cremoris (strain SK11).
OG   Plasmid pSK111, and Plasmid pLACR3.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272622;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], POSSIBLE SUBCELLULAR LOCATION, AND
RP   ROLE IN PRTP PROTEASE SECRETION.
RC   PLASMID=pSK111;
RX   PubMed=2496115;
RA   Vos P., van Asseldonk M., van Jeveren F., Siezen R., Simons G.,
RA   de Vos W.M.;
RT   "A maturation protein is essential for production of active forms of
RT   Lactococcus lactis SK11 serine proteinase located in or secreted from
RT   the cell envelope.";
RL   J. Bacteriol. 171:2795-2802(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SK11; PLASMID=pLACR3;
RX   PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA   Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B.,
RA   Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N.,
RA   Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K.,
RA   Goodstein D.M., Hawkins T., Plengvidhya V., Welker D., Hughes J.,
RA   Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B.,
RA   Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E.,
RA   Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C.,
RA   Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J.,
RA   Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S.,
RA   Weimer B.C., Mills D.A.;
RT   "Comparative genomics of the lactic acid bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 294-299.
RC   PLASMID=pSK111;
RX   PubMed=2166472;
RA   Haandrikman A.J., van Leeuwen C., Kok J., Vos P., de Vos W.M.,
RA   Venema G.;
RT   "Insertion elements on lactococcal proteinase plasmids.";
RL   Appl. Environ. Microbiol. 56:1890-1896(1990).
CC   -!- FUNCTION: This protein is essential for production of active forms
CC       of the serine proteinase located in or secreted from the cell
CC       envelope.
CC   -!- CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline
CC       (omega=0).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor (Potential).
CC   -!- SIMILARITY: Belongs to the PrsA family.
CC   -!- SIMILARITY: Contains 1 PpiC domain.
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DR   EMBL; J04962; AAA03532.1; -; Unassigned_DNA.
DR   EMBL; CP000428; ABJ74079.1; -; Genomic_DNA.
DR   EMBL; M37395; AAA25209.1; -; Genomic_DNA.
DR   PIR; A32314; A32313.
DR   RefSeq; WP_011669080.1; NC_008505.1.
DR   RefSeq; YP_796510.1; NC_008505.1.
DR   ProteinModelPortal; Q02VE3; -.
DR   STRING; 272622.LACR_C43; -.
DR   EnsemblBacteria; ABJ74079; ABJ74079; LACR_C43.
DR   GeneID; 4405838; -.
DR   KEGG; llc:LACR_C43; -.
DR   PATRIC; 22286544; VBILacLac38071_0072.
DR   eggNOG; COG0760; -.
DR   HOGENOM; HOG000014031; -.
DR   KO; K07533; -.
DR   OMA; HVTIKDK; -.
DR   OrthoDB; EOG66XBH5; -.
DR   BioCyc; LLAC272622:GJUG-2654-MONOMER; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006457; P:protein folding; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_01145; Foldase_PrsA; 1.
DR   InterPro; IPR023059; Foldase_PrsA.
DR   InterPro; IPR000297; PPIase_PpiC.
DR   InterPro; IPR023058; PPIase_PpiC_CS.
DR   InterPro; IPR027304; Trigger_fact/SurA_dom.
DR   Pfam; PF00639; Rotamase; 1.
DR   SUPFAM; SSF109998; SSF109998; 1.
DR   PROSITE; PS01096; PPIC_PPIASE_1; 1.
DR   PROSITE; PS50198; PPIC_PPIASE_2; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Complete proteome; Isomerase; Lipoprotein; Membrane;
KW   Palmitate; Plasmid; Rotamase; Signal.
FT   SIGNAL        1     23       Potential.
FT   CHAIN        24    299       Foldase protein PrsA.
FT                                /FTId=PRO_0000272037.
FT   DOMAIN      144    236       PpiC.
FT   LIPID        24     24       N-palmitoyl cysteine (Potential).
FT   LIPID        24     24       S-diacylglycerol cysteine (Potential).
SQ   SEQUENCE   299 AA;  33167 MW;  3A7B775DE3324F5B CRC64;
     MKKKMRLKVL LASTATALLL LSGCQSNQTD QTVATYSGGK VTESSFYKEL KQSPTTKTML
     ANMLIYRALN HAYGKSVSTK TVNDAYDSYK QQYGENFDAF LSQNGFSRSS FKESLRTNFL
     SEVALKKLKK VSESQLKAAW KTYQPKVTVQ HILTSDEDTA KQVISDLAAG KDFAMLAKTD
     SIDTATKDNG GKISFELNNK TLDATFKDAA YKLKNGDYTQ TPVKVTDGYE VIKMINHPAK
     GTFTSSKKAL TASVYAKWSR DSSIMQRVIS QVLKNQHVTI KDKDLADALD SYKKLATTN
//
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