GenomeNet

Database: UniProt
Entry: Q02YB4
LinkDB: Q02YB4
Original site: Q02YB4 
ID   TRPC_LACLS              Reviewed;         264 AA.
AC   Q02YB4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   19-FEB-2014, entry version 49.
DE   RecName: Full=Indole-3-glycerol phosphate synthase;
DE            Short=IGPS;
DE            EC=4.1.1.48;
GN   Name=trpC; OrderedLocusNames=LACR_1552;
OS   Lactococcus lactis subsp. cremoris (strain SK11).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272622;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SK11;
RX   PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA   Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B.,
RA   Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N.,
RA   Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K.,
RA   Goodstein D.M., Hawkins T., Plengvidhya V., Welker D., Hughes J.,
RA   Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B.,
RA   Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E.,
RA   Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C.,
RA   Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J.,
RA   Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S.,
RA   Weimer B.C., Mills D.A.;
RT   "Comparative genomics of the lactic acid bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC   -!- CATALYTIC ACTIVITY: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-
CC       phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5.
CC   -!- SIMILARITY: Belongs to the TrpC family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000425; ABJ73058.1; -; Genomic_DNA.
DR   RefSeq; YP_809480.1; NC_008527.1.
DR   ProteinModelPortal; Q02YB4; -.
DR   STRING; 272622.LACR_1552; -.
DR   EnsemblBacteria; ABJ73058; ABJ73058; LACR_1552.
DR   GeneID; 4433544; -.
DR   KEGG; llc:LACR_1552; -.
DR   PATRIC; 22289971; VBILacLac38071_1731.
DR   eggNOG; COG0134; -.
DR   HOGENOM; HOG000230462; -.
DR   KO; K01609; -.
DR   OMA; LEIAKMP; -.
DR   OrthoDB; EOG6WT8JX; -.
DR   ProtClustDB; PRK00278; -.
DR   BioCyc; LLAC272622:GJUG-1552-MONOMER; -.
DR   UniPathway; UPA00035; UER00043.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00134_B; IGPS_B; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Decarboxylase; Lyase; Tryptophan biosynthesis.
FT   CHAIN         1    264       Indole-3-glycerol phosphate synthase.
FT                                /FTId=PRO_1000018489.
SQ   SEQUENCE   264 AA;  29861 MW;  68D83A50BCB23E84 CRC64;
     MNIKEGKFLE TILAEKKQEI AQMPDENSKP IRQTYRLYDY LKKHSDQLQV IAEVKKASPS
     LGDINLEVDI IAQAKNYEQA GAAMISVLTD PVFFKGNIEY LREISKNVQI PTLNKDFIID
     KKQINRALNA GATVILLIVA CFENDFEKLE ELYNYAISLG LEVLVETHNK AELDRAHQLA
     AKIIGVNNRN LKTFEVSLQN STDLVPYFKE ENVYISESGI FGKKEAQKVA ENFNGILVGT
     ALMQANNLTK SLTDLKIKRK NDEH
//
DBGET integrated database retrieval system