ID DCOA_SALTY Reviewed; 591 AA.
AC Q03030;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 01-MAY-2013, entry version 94.
DE RecName: Full=Oxaloacetate decarboxylase alpha chain;
DE EC=4.1.1.3;
GN Name=oadA1; Synonyms=oadA; OrderedLocusNames=STM0055;
GN and
GN Name=oadA2; OrderedLocusNames=STM3352;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RX PubMed=1331067;
RA Woehlke G., Wifling K., Dimroth P.;
RT "Sequence of the sodium ion pump oxaloacetate decarboxylase from
RT Salmonella typhimurium.";
RL J. Biol. Chem. 267:22798-22803(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M.,
RA Waterston R., Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium
RT LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Lyase and sodium transporter.
CC -!- CATALYTIC ACTIVITY: Oxaloacetate = pyruvate + CO(2).
CC -!- COFACTOR: Biotin.
CC -!- SUBUNIT: Composed of three chains (alpha, beta, and gamma).
CC -!- SIMILARITY: Contains 1 biotinyl-binding domain.
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DR EMBL; M96434; AAA02973.1; -; Unassigned_DNA.
DR EMBL; AE006468; AAL19019.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL22221.1; -; Genomic_DNA.
DR PIR; B44465; B44465.
DR RefSeq; NP_459060.1; NC_003197.1.
DR RefSeq; NP_462262.1; NC_003197.1.
DR ProteinModelPortal; Q03030; -.
DR SMR; Q03030; 3-449.
DR STRING; 99287.STM3352; -.
DR TCDB; 3.B.1.1.1; Na+-transporting carboxylic acid decarboxylase (NaT-DC) family.
DR EnsemblBacteria; AAL19019; AAL19019; STM0055.
DR EnsemblBacteria; AAL22221; AAL22221; STM3352.
DR GeneID; 1251573; -.
DR GeneID; 1254875; -.
DR KEGG; stm:STM0055; -.
DR KEGG; stm:STM3352; -.
DR PATRIC; 32378375; VBISalEnt20916_0057.
DR eggNOG; COG0511; -.
DR HOGENOM; HOG000231389; -.
DR KO; K01571; -.
DR OMA; VEKSYEN; -.
DR ProtClustDB; PRK14040; -.
DR GO; GO:0008948; F:oxaloacetate decarboxylase activity; IEA:EC.
DR GO; GO:0008152; P:metabolic process; IEA:GOC.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.70; -; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR003379; Carboxylase_cons_dom.
DR InterPro; IPR005776; OadA.
DR InterPro; IPR000891; PYR_CT.
DR InterPro; IPR011053; Single_hybrid_motif.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR Pfam; PF02436; PYC_OADA; 1.
DR SUPFAM; SSF51230; Hybrid_motif; 1.
DR TIGRFAMs; TIGR01108; oadA; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 3: Inferred from homology;
KW Biotin; Complete proteome; Decarboxylase; Ion transport; Lyase;
KW Reference proteome; Sodium; Sodium transport; Transport.
FT INIT_MET 1 1 Removed (By similarity).
FT CHAIN 2 591 Oxaloacetate decarboxylase alpha chain.
FT /FTId=PRO_0000146834.
FT DOMAIN 523 591 Biotinyl-binding.
FT MOD_RES 557 557 N6-biotinyllysine (By similarity).
SQ SEQUENCE 591 AA; 63207 MW; EE9CF9191E71D6BE CRC64;
MTIAITDVVL RDAHQSLFAT RLRLDDMLPI AAALDDVGYG SLECWGGATF DACIRFLGED
PWLRLRELKK AMPKTPLQML LRGQNLLGYR HYADDVVERF VERAVKNGMD VFRVFDAMND
PRNMKAALQA VRSHGAHAQG TLSYTTSPAH TLQTWLDLTE QLLETGVDSI AIKDMSGILT
PMAAYELVSE IKKRFEVRLH LHCHATTGMA EMALLKAIEA GVDGVDTAIS SMSATYGHPA
TEALVATLAG TEHDTGLDIL KLENIAAYFR EVRKKYHAFE GQLKGYDSRI LVAQVPGGML
TNLESQLKQQ NAADKLDQVL AEIPRVREDL GFIPLVTPTS QIVGTQAVLN VLTGERYKTI
AKETAGILKG EYGHTPVPVN AALQARVLEG GAPVTCRPAD LLKPELAELE ADVRRQAQEK
GITLAGNAID DVLTVALFPQ IGLKFLENRN NPAAFEPLPQ AEAAQPVAKA EKPAASGIYT
VEVEGKAFVV KVSDGGDISQ LTAAVPAASS APVQAAAPAG AGTPVTAPLA GNIWKVIATE
GQTVAEGDVL LILEAMKMET EIRAAQAGTV RGIAVKSGDA VSVGDTLMTL A
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