ID Q03GH0_PEDPA Unreviewed; 577 AA.
AC Q03GH0;
DT 14-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 14-NOV-2006, sequence version 1.
DT 24-JAN-2024, entry version 90.
DE SubName: Full=Pyruvate oxidase {ECO:0000313|EMBL:ABJ67702.1};
DE EC=1.2.3.3 {ECO:0000313|EMBL:ABJ67702.1};
GN OrderedLocusNames=PEPE_0639 {ECO:0000313|EMBL:ABJ67702.1};
OS Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 /
OS 183-1w).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Pediococcus.
OX NCBI_TaxID=278197 {ECO:0000313|EMBL:ABJ67702.1, ECO:0000313|Proteomes:UP000000773};
RN [1] {ECO:0000313|EMBL:ABJ67702.1, ECO:0000313|Proteomes:UP000000773}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w
RC {ECO:0000313|Proteomes:UP000000773};
RX PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA Makarova K., Slesarev A., Wolf Y., Sorokin A., Mirkin B., Koonin E.,
RA Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA Baldwin K., Lee J.H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J., Hutkins R.,
RA O'Sullivan D., Steele J., Unlu G., Saier M., Klaenhammer T., Richardson P.,
RA Kozyavkin S., Weimer B., Mills D.;
RT "Comparative genomics of the lactic acid bacteria.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000422; ABJ67702.1; -; Genomic_DNA.
DR RefSeq; WP_011673183.1; NC_008525.1.
DR AlphaFoldDB; Q03GH0; -.
DR STRING; 278197.PEPE_0639; -.
DR GeneID; 33062818; -.
DR KEGG; ppe:PEPE_0639; -.
DR eggNOG; COG0028; Bacteria.
DR HOGENOM; CLU_013748_3_0_9; -.
DR OMA; TLMGWGA; -.
DR OrthoDB; 4494979at2; -.
DR Proteomes; UP000000773; Chromosome.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0047112; F:pyruvate oxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd02014; TPP_POX; 1.
DR CDD; cd07039; TPP_PYR_POX; 1.
DR Gene3D; 1.10.10.940; -; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR047211; POXB-like.
DR InterPro; IPR014092; Pyruvate_oxidase.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR InterPro; IPR047212; TPP_POXB-like.
DR InterPro; IPR047210; TPP_PYR_POXB-like.
DR NCBIfam; TIGR02720; pyruv_oxi_spxB; 1.
DR PANTHER; PTHR42981; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR PANTHER; PTHR42981:SF2; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000313|EMBL:ABJ67702.1};
KW Pyruvate {ECO:0000313|EMBL:ABJ67702.1};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 6..120
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 195..322
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 384..530
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 577 AA; 63409 MW; 67D2C97933799CCF CRC64;
MTEKINASDA MIKVLESWGV HNVYGLPGGS FDSTMNALYN RKSTINYVQV RHEEVGALAA
VGEAKVTGKL GVTFGSAGPG AVHLLNGLYD AKHDHMPVLA LVGQVPTTLM NTDYFQELNE
NPIFTDVAVY NRTVMTAEQM PHVVDEAIRQ AYKYSGVAVV TIPKDLGWQP IEDNYVSSAN
LYQAPILPEP DVKQVDEALE ILSNAKHPVM YIGQGTRGAG SDIIALSEKL HIPIVTSALA
KGIVPDSYKA NMGSAGRVAT KPGVEVLQAA DAVMFVGSDF PFQPYFVAPD AKYIQVDIDA
SKFGRRHVVD LAILADSHKF LKVMLEKAET TAESKWYKAA LENKKNWEEW KNSFVGQQDT
PLNVENVFAK INALATDDAI FQVDVGNVTI DGMRFLKADQ AQRFTTSGWY ATMGYALPAA
IGAQAEYPDR QVWSISGDGG YAMVMQDVLT QVKYHMPIIN VILTNESLGF IEAEQDDSKQ
PHSGVDLIDA DYGTSAQALG AEGFEVRTYD ELEQAFEKAK DRKGPVVIDI KITNLRPLPV
EQLLLDKETQ DPEAVEQFVK KYHAESLIPF RKLLEEA
//