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Database: UniProt
Entry: Q03KR2_STRTD
LinkDB: Q03KR2_STRTD
Original site: Q03KR2_STRTD 
ID   Q03KR2_STRTD            Unreviewed;       280 AA.
AC   Q03KR2;
DT   14-NOV-2006, integrated into UniProtKB/TrEMBL.
DT   14-NOV-2006, sequence version 1.
DT   09-JUL-2014, entry version 58.
DE   RecName: Full=tRNA pseudouridine synthase B;
DE            EC=5.4.99.25;
DE   AltName: Full=tRNA pseudouridine(55) synthase;
DE   AltName: Full=tRNA pseudouridylate synthase;
DE   AltName: Full=tRNA-uridine isomerase;
GN   Name=truB; OrderedLocusNames=STER_1000;
OS   Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=322159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-491 / LMD-9;
RX   PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA   Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B.,
RA   Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N.,
RA   Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K.,
RA   Goodstein D.M., Hawkins T., Plengvidhya V., Welker D., Hughes J.,
RA   Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B.,
RA   Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E.,
RA   Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C.,
RA   Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J.,
RA   Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S.,
RA   Weimer B.C., Mills D.A.;
RT   "Comparative genomics of the lactic acid bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-
CC       55 in the psi GC loop of transfer RNAs (By similarity).
CC   -!- CATALYTIC ACTIVITY: tRNA uridine(55) = tRNA pseudouridine(55).
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase TruB family.
CC       Type 1 subfamily.
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DR   EMBL; CP000419; ABJ66210.1; -; Genomic_DNA.
DR   RefSeq; YP_820406.1; NC_008532.1.
DR   ProteinModelPortal; Q03KR2; -.
DR   STRING; 322159.STER_1000; -.
DR   EnsemblBacteria; ABJ66210; ABJ66210; STER_1000.
DR   GeneID; 4438457; -.
DR   KEGG; ste:STER_1000; -.
DR   PATRIC; 19799320; VBIStrThe129203_1012.
DR   eggNOG; COG0130; -.
DR   HOGENOM; HOG000231225; -.
DR   KO; K03177; -.
DR   OMA; IQPIDAF; -.
DR   OrthoDB; EOG6358D3; -.
DR   BioCyc; STHE322159:GJ9F-1000-MONOMER; -.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_01080; TruB_bact; 1.
DR   InterPro; IPR002501; PsdUridine_synth.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR   InterPro; IPR015225; tRNA_psdUridine_synth_fam2_C.
DR   InterPro; IPR014780; tRNA_psdUridine_synth_TruB.
DR   PANTHER; PTHR13767; PTHR13767; 1.
DR   Pfam; PF09142; TruB_C; 1.
DR   Pfam; PF01509; TruB_N; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00431; TruB; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase; Lyase; tRNA processing.
FT   ACT_SITE     26     26       Nucleophile (By similarity){EA3}.
SQ   SEQUENCE   280 AA;  30525 MW;  293F640252FEDAEA CRC64;
     MTSHDAVFKL RKILHEKKIG HGGTLDPDVT GVLPIAVGKA TRVIEYMTEA GKVYEGEITI
     GFSTTTEDAS GEVVQTTPIT ELDGATVDQA MASFEGEITQ IPPMYSAVKI NGKKLYEYAR
     AGEEVERPQR QVKITEFVRT SPIELENGTA RFTFRVACSK GTYVRTLSVD LGVKLGFASH
     MSALRRTASA GLTLDSSLTL SQISEMVEAG DQSFLLPIEF GVQDLPAVQV TEDDAKEISF
     GRFISINSQE PLVAAFLGDK VLAIMEKRGQ VYKPRKVLSQ
//
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